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RBPMS antibody

RRID:AB_1658943

Antibody ID

AB_1658943

Target Antigen

RBPMS human

Proper Citation

(Abcam Cat# ab80294, RRID:AB_1658943)

Clonality

polyclonal antibody

Reference

PMID:28641110

Comments

validation status unknown, seller recommendations provided in 2012: ELISA; Western Blot; ELISA, Western Blot

Host Organism

rabbit

Vendor

Abcam

Cat Num

ab80294

Publications that use this research resource

Sox11 Expression Promotes Regeneration of Some Retinal Ganglion Cell Types but Kills Others.

  • Norsworthy MW
  • Neuron
  • 2017 Jun 21

Literature context:


Abstract:

At least 30 types of retinal ganglion cells (RGCs) send distinct messages through the optic nerve to the brain. Available strategies of promoting axon regeneration act on only some of these types. Here we tested the hypothesis that overexpressing developmentally important transcription factors in adult RGCs could reprogram them to a "youthful" growth-competent state and promote regeneration of other types. From a screen of transcription factors, we identified Sox11 as one that could induce substantial axon regeneration. Transcriptome profiling indicated that Sox11 activates genes involved in cytoskeletal remodeling and axon growth. Remarkably, α-RGCs, which preferentially regenerate following treatments such as Pten deletion, were killed by Sox11 overexpression. Thus, Sox11 promotes regeneration of non-α-RGCs, which are refractory to Pten deletion-induced regeneration. We conclude that Sox11 can reprogram adult RGCs to a growth-competent state, suggesting that different growth-promoting interventions promote regeneration in distinct neuronal types.

Funding information:
  • NEI NIH HHS - P30 EY012196()
  • NEI NIH HHS - R01 EY021342()
  • NEI NIH HHS - R01 EY021526()
  • NEI NIH HHS - R01 EY026939()
  • NHLBI NIH HHS - T32 HL007901()
  • NICHD NIH HHS - P30 HD018655()
  • NINDS NIH HHS - P30 NS062691()