X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Vimentin Antibody

RRID:AB_10004971

Antibody ID

AB_10004971

Target Antigen

Vimentin human, rat, mouse

Proper Citation

(Novus Cat# NBP1-40730, RRID:AB_10004971)

Clonality

monoclonal antibody

Reference

PMID:29316425

Comments

Flow cytometry / FACS analysis, Immunocytochemistry, Immunohistochemistry, Western Blot

Clone ID

EPR3776

Host Organism

rabbit

Vendor

Novus

Cat Num

NBP1-40730

Publications that use this research resource

Hedgehog Pathway Drives Fusion-Negative Rhabdomyosarcoma Initiated From Non-myogenic Endothelial Progenitors.

  • Drummond CJ
  • Cancer Cell
  • 2018 Jan 8

Literature context:


Abstract:

Rhabdomyosarcoma (RMS) is a pediatric soft tissue sarcoma that histologically resembles embryonic skeletal muscle. RMS occurs throughout the body and an exclusively myogenic origin does not account for RMS occurring in sites devoid of skeletal muscle. We previously described an RMS model activating a conditional constitutively active Smoothened mutant (SmoM2) with aP2-Cre. Using genetic fate mapping, we show SmoM2 expression in Cre-expressing endothelial progenitors results in myogenic transdifferentiation and RMS. We show that endothelium and skeletal muscle within the head and neck arise from Kdr-expressing progenitors, and that hedgehog pathway activation results in aberrant expression of myogenic specification factors as a potential mechanism driving RMS genesis. These findings suggest that RMS can originate from aberrant development of non-myogenic cells.

Funding information:
  • NCI NIH HHS - K08 CA151649()
  • NCI NIH HHS - P30 CA021765()
  • NCI NIH HHS - R01 CA216344()
  • NIAID NIH HHS - R21AI094333(United States)