URL: http://antibodyregistry.org/AB_2721192
Proper Citation: (Nicholas M. Kanaan at Michigan State University Cat# Tau12, RRID:AB_2721192)
Target Antigen: tau
Host Organism: mouse
Clonality: monoclonal
Comments: Originally created by Dr. Lester I. Binder at Northwestern University---Original Report: Ghoshal N, García-Sierra F, Wuu J, Leurgans S, Bennett DA, Berry RW, Binder LI. Tau conformational changes correspond to impairments of episodic memory in mild cognitive impairment and Alzheimer's disease. Exp Neurol. 2002 177(2):475-93. PMID: 12429193.Epitope: Pathological conformations involving the amino terminus of tau occur early in Alzheimer's disease and are differentially detected by monoclonal antibodies. Combs B, Hamel C, Kanaan NM. Neurobiol Dis. 2016 Oct;94:18-31. doi: 10.1016/j.nbd.2016.05.016. Epub 2016 May 31. PMID: 27260838; Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease. Horowitz PM, Patterson KR, Guillozet-Bongaarts AL, Reynolds MR, Carroll CA, Weintraub ST, Bennett DA, Cryns VL, Berry RW, Binder LI. J Neurosci. 2004 Sep 8;24(36):7895-902. PMID: 15356202; Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's diseaseHorowitz PM, Patterson KR, Guillozet-Bongaarts AL, Reynolds MR, Carroll CA, Weintraub ST, Bennett DA, Cryns VL, Berry RW, Binder LI. . J Neurosci. 2004. 24(36):7895-902. PMID: 15356202.
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