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ApoER2 (3E) antibody

RRID:AB_2336895

Antibody ID

AB_2336895

Target Antigen

Recombinant protein corresponding to amino acids 757-871 of mouse ApoER2 null

Vendor

K. Nakajima, Keio University; Tokyo; Japan

Cat Num

ApoER2 (3E)

Proper Citation

(K. Nakajima, Keio University; Tokyo; Japan Cat# ApoER2 (3E), RRID:AB_2336895)

Reference

PMID:25308109

Clonality

monoclonal antibody

Clone ID

4H3E6

Host Organism

rat

Publications that use this research resource

Reelin receptors ApoER2 and VLDLR are expressed in distinct spatiotemporal patterns in developing mouse cerebral cortex.

  • Hirota Y
  • J. Comp. Neurol.
  • 2015 Feb 15

Literature context: oclonal, Clone 4C4G5 (4G), RRID:AB_23368950.5 (WB) 1 (IF)VLDLRRecombinant


Abstract:

In mammalian developing brain, neuronal migration is regulated by a variety of signaling cascades, including Reelin signaling. Reelin is a glycoprotein that is mainly secreted by Cajal-Retzius neurons in the marginal zone, playing essential roles in the formation of the layered neocortex via its receptors, apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR). However, the precise mechanisms by which Reelin signaling controls the neuronal migration process remain unclear. To gain insight into how Reelin signaling controls individual migrating neurons, we generated monoclonal antibodies against ApoER2 and VLDLR and examined the localization of Reelin receptors in the developing mouse cerebral cortex. Immunohistochemical analyses revealed that VLDLR is localized to the distal portion of leading processes in the marginal zone (MZ), whereas ApoER2 is mainly localized to neuronal processes and the cell membranes of multipolar cells in the multipolar cell accumulation zone (MAZ). These different expression patterns may contribute to the distinct actions of Reelin on migrating neurons during both the early and late migratory stages in the developing cerebral cortex.

Funding information:
  • NINDS NIH HHS - R01 NS092786(United States)