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Organism Name
ZSF1-Leprfa, Leprcp/Crl
RRID:RGD_2312512 RRID Copied  
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Organism Information

URL: https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=2312512

Proper Citation: RRID:RGD_2312512

Description: Rattus norvegicus with name ZSF1-Leprfa, Leprcp/Crl from RGD.

Species: Rattus norvegicus

Notes: This F1 model was developed by crossing rat strains with two separate leptin receptor mutations (fa and cp), the lean female ZDF rat (+/fa) and the lean male SHHF rat (+/facp) ( RGD:401901201). Offspringcarring both mutations (fa:facp) are obese and develop insulin resistance, hyperglycaemia, and mild hypertension (ZSF1 obese). The heterozygous or wild type offspring (ZSF1 lean) are lean and exhibit no signs of obesity and diabetes. This model was developed at Genetic Models International, Indianapolis. To Charles River in 2001. The progeny that are heterozygous for leptin receptor or wild type are lean and are used as control for the obese counter part. Charles River Laboratories , Charles River Laboratories

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Data and Source Information

Source: Integrated Animals

Source Database: Rat Genome Database (RGD)