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Motor, cognitive, anxiety-like, and depressive-like behavior following one or two diffuse TBIs in the mouseDOI:10.34945/F5BS3RDATASET CITATIONRowe R. K., Lifshitz J. (2023) Motor, cognitive, anxiety-like, and depressive-like behavior following one or two diffuse TBIs in the mouse. Open Data Commons for Traumatic Brain Injury. ODC-TBI:828 http://doi.org/10.34945/F5BS3RABSTRACTSTUDY PURPOSE: Behavioral impairments can manifest from a single traumatic brain injury (TBI) or repetitive TBI, particularly when subsequent injuries occur before the initial injury heals. We investigated behavior as a primary outcome following TBI.DATA COLLECTED: Adult (2-4 months old) male C57BL/6 mice received sham or diffuse TBI by midline fluid percussion injury (moderate injury, 1.4 atm). The brain-injured mice received one TBI or two TBIs with an inter-injury interval of approximately 3-9 hours. Motor behavior was tested using the rotarod and modified neurological severity score (NSS) task at 2, 5, and 7 days post-injury. Affective behavioral assessments were tested using novel object recognition (NOR), elevated plus maze, and forced swim task at 7, 14, and/or 28 days post-injury.CONCLUSIONS: Both a single TBI and repetitive TBI resulted in motor impairments compared to shams as measured by the rotarod and NSS task. Diffuse TBI did not impair cognitive function assessed by NOR. There were also no differences between groups on the elevated plus maze. Repetitive TBI, but not a single TBI, resulted in depressive-like behavior assessed with the forced swim task.KEYWORDSConcussion; TBI; mouse; Cognition; motor behavior; depressionPROVENANCE / ORIGINATING PUBLICATIONS
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DATASET INFOContact: Rowe Rachel (rachel.rowe@colorado.edu)Lab: Rachel Rowe
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