Searching the Resource Information Network
Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.
As the global aging population rises, finding effective interventions to improve aging health is crucial. Drug repurposing, utilizing existing drugs for new purposes, presents a promising strategy for rapid implementation. We explored naltrexone from the Library of Integrated Network-based Cellular Signatures (LINCS) based on several selection criteria. Low-dose naltrexone (LDN) has gained attention for treating various diseases, yet its impact on longevity remains underexplored. Our study on C. elegans demonstrated that a low dose, but not high dose, of naltrexone extended the healthspan and lifespan. This effect was mediated through SKN-1 (NRF2 in mammals) signaling, influencing innate immune gene expression and upregulating oxidative stress responses. With LDN's low side effects profile, our findings underscore its potential as a geroprotector, suggesting further exploration for promoting healthy aging in humans is warranted.
Pubmed ID: 38799567
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
Caenorhabditis elegans with name skn-1(zu67) IV/nT1 [unc-?(n754) let-?] (IV;V). from WB.
View all literature mentionsCaenorhabditis elegans with name atf-4(ok576) X. from WB.
View all literature mentionsCaenorhabditis elegans with name unc-13(n2813) I. from WB.
View all literature mentionsCaenorhabditis elegans with name cdk-5(ok626) III. from WB.
View all literature mentionsCaenorhabditis elegans with name pmk-1(km25) IV. from WB.
View all literature mentionsCaenorhabditis elegans with name ldIs7[skn-1::gfp] from WB.
View all literature mentionsCaenorhabditis elegans with name daf-16(mu86)I from WB.
View all literature mentionsCaenorhabditis elegans with name muIs84 [(pAD76) sod-3p::GFP + rol-6(su1006)]. from WB.
View all literature mentionsCaenorhabditis elegans with name aak-2(ok524) X. from WB.
View all literature mentionsCaenorhabditis elegans with name dvIs19 [(pAF15)gst-4p::GFP::NLS] III. from WB.
View all literature mentionsCaenorhabditis elegans with name C. elegans wild type (ancestral). from WB.
View all literature mentions