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Hedgehog signaling plays pivotal roles in the development and homeostasis of epithelial barrier tissues. However, whether and how Hedgehog signaling directly regulates innate immunity in epithelial cells remains unknown. By utilizing C. elegans epidermis as the model, we found that several Hedgehog receptors are involved in cell-autonomous regulation of the innate immune response in the epidermis. Particularly, loss of the Patched family receptor induces aberrant up-regulation of epidermal antimicrobial peptides in a STAT-dependent manner. External or internal insult to the epidermis triggers rapid rearrangement of Patched distribution along the plasma membrane, indicating that the Hedgehog (Hh) receptor is likely involved in recognition and defense against epidermal damage. Loss of PTCH1 function in primary human keratinocytes and intact mouse skin also results in STAT-dependent immune activation. These findings reveal an evolutionally conserved immune-surveillance function of Hedgehog receptors and an insult-sensing and response strategy of epithelial tissues.
Pubmed ID: 37527037
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This polyclonal targets Human Patched 2
View all literature mentionsThis monoclonal targets Stat1, phospho (Tyr701)
View all literature mentionsThis monoclonal targets NF-KappaB p65, phospho (Ser536)
View all literature mentionsThis polyclonal targets IL-6
View all literature mentionsThis unknown targets IgG (H+L)
View all literature mentionsThis monoclonal targets Alpha Tubulin
View all literature mentionsThis monoclonal targets Phospho-Stat5 (Tyr694) (C11C5) Rabbit mAb
View all literature mentionsThis unknown targets
View all literature mentionsThis monoclonal targets intermediate filament subunit
View all literature mentionsThis unknown targets IgG (H+L)
View all literature mentionsThis polyclonal targets Patched / PTCH
View all literature mentionsThis monoclonal targets Phospho-Stat3 (Tyr705)
View all literature mentionsThis monoclonal targets Phospho-I B (Ser32)
View all literature mentionsThis monoclonal targets Stat3
View all literature mentionsThis monoclonal targets IkappaB-alpha
View all literature mentionsThis monoclonal targets Beta Actin
View all literature mentionsThis monoclonal targets GFP
View all literature mentionsThis polyclonal targets Smoothened antibody
View all literature mentionsThis monoclonal targets Green fluorescent protein (GFP)
View all literature mentionsThis monoclonal targets STAT5A;STAT5B
View all literature mentionsThis unknown targets Mouse tubulin (alpha-)
View all literature mentionsThis monoclonal targets STAT2
View all literature mentionsC. elegans RNAi feeding library distributed by Source BioScience Ltd. Designed for genome wide study of gene function in C. elegans through loss of function studies.
View all literature mentionsMus musculus with name B6N.129S6(Cg)-Krt5tm1.1(cre/ERT2)Blh/J from IMSR.
View all literature mentionsMus musculus with name B6;129T2-Ptch1tm1Bjw/WreyJ from IMSR.
View all literature mentions