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Essential role of neuron-enriched diacylglycerol kinase (DGK), DGKbeta in neurite spine formation, contributing to cognitive function.

Yasuhito Shirai | Takeshi Kouzuki | Kenichi Kakefuda | Shigeki Moriguchi | Atsushi Oyagi | Kyoji Horie | Shin-ya Morita | Masamitsu Shimazawa | Kohji Fukunaga | Junji Takeda | Naoaki Saito | Hideaki Hara
PloS one | 2010

Diacylglycerol (DG) kinase (DGK) phosphorylates DG to produce phosphatidic acid (PA). Of the 10 subtypes of mammalian DGKs, DGKbeta is a membrane-localized subtype and abundantly expressed in the cerebral cortex, hippocampus, and caudate-putamen. However, its physiological roles in neurons and higher brain function have not been elucidated.

Pubmed ID: 20657643

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