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Haploinsufficient Bmp4 ocular phenotypes include anterior segment dysgenesis with elevated intraocular pressure.

B Chang | R S Smith | M Peters | O V Savinova | N L Hawes | A Zabaleta | S Nusinowitz | J E Martin | M L Davisson | C L Cepko | B L Hogan | S W John
BMC genetics | 2001

Glaucoma is a blinding disease usually associated with high intraocular pressure (IOP). In some families, abnormal anterior segment development contributes to glaucoma. The genes causing anterior segment dysgenesis and glaucoma in most of these families are not identified and the affected developmental processes are poorly understood. Bone morphogenetic proteins (BMPs) participate in various developmental processes. We tested the importance of Bmp4 gene dosage for ocular development and developmental glaucoma.

Pubmed ID: 11722794

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Associated grants

  • Agency: NCI NIH HHS, United States
    Id: R03 CA134196
  • Agency: NCI NIH HHS, United States
    Id: CA134196

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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