Searching the RRID Resource Information Network
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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
| Organism Name | Proper Citation | Species | Synonyms |
Notes |
Phenotype | Affected Gene | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
STOCK Rettm1Cos/Kctt Resource Report Resource Website Issue Issue |
RRID:IMSR_EM:02081 | Mus musculus |
Ret KO. Cg-Ret |
gene symbol note: ret proto-oncogene; mutant strain: Ret | ret proto-oncogene | targeted mutation 1; Frank Costantini | EM:02081 | European Mouse Mutant Archive | EMMA | embryo | 2026-07-24 10:29:41 | 0 | ||||
|
CByIco.129S7-Ifngtm1Ts/Cnrm Resource Report Resource Website Issue |
RRID:IMSR_EM:02106 | Mus musculus |
BALB/cByJIco IFNg-/-. CByIco.129S7-Ifng |
gene symbol note: interferon gamma; mutant strain: Ifng | interferon gamma | targeted mutation 1; Timothy Stewart | EM:02106 | European Mouse Mutant Archive | EMMA | embryo | 2026-07-24 10:29:41 | 0 | ||||
|
B6;129S7-Prnptm1Cwe Tg(Igh-15B3Vh/Ighm*a)502Zbz/Cnrm Resource Report Resource Website Issue Issue |
RRID:IMSR_EM:02154 | Mus musculus |
B6129-Prnp |
gene symbol note: prion protein|transgene insertion 502; Universitatsspital Zurich; Biologisches Zentrallaboratorium; mutant strain: Prnp|Tg(Igh-15B3Vh/Ighm*a)502Zbz | prion protein|transgene insertion 502; Universitatsspital Zurich; Biologisches Zentrallaboratorium | targeted mutation 1; Charles Weissmann|transgene insertion 502; Universitatsspital Zurich; Biologisches Zentrallaboratorium | EM:02154 | European Mouse Mutant Archive | EMMA | embryo | 2026-07-24 10:29:42 | 0 | ||||
|
B10ScSn.BXSB-(D1Mit3-D1Mit235) Chr YBXSB/MpJ/BjmjrH Resource Report Resource Website Issue |
RRID:IMSR_EM:02280 | Mus musculus | B10.Yaa.Bxs4(20-48) | gene symbol note: accelerated autoimmunity and lymphoproliferation transposition; mutant strain: Yaa | accelerated autoimmunity and lymphoproliferation transposition | accelerated autoimmunity and lymphoproliferation | EM:02280 | European Mouse Mutant Archive | EMMA | sperm | MGI:5494444, IMSR_HAR:3417 | 2026-07-24 10:29:43 | 0 | |||
|
B10ScSn.BXSB-(D1Mit235-D1Mit1000) Chr YBXSB/MpJ/BjmjrH Resource Report Resource Website Issue |
RRID:IMSR_EM:02278 | Mus musculus | gene symbol note: accelerated autoimmunity and lymphoproliferation transposition; mutant strain: Yaa | accelerated autoimmunity and lymphoproliferation transposition | accelerated autoimmunity and lymphoproliferation | EM:02278 | European Mouse Mutant Archive | EMMA | sperm | MGI:5494438, IMSR_HAR:3418 | 2026-07-24 10:29:43 | 0 | ||||
|
B10ScSn.BXSB-(D1Mit123-D1Mit1000) Chr YBXSB/MpJ/BjmjrH Resource Report Resource Website Issue |
RRID:IMSR_EM:02279 | Mus musculus | B10.Yaa.Bxs1.4(40-67) | gene symbol note: accelerated autoimmunity and lymphoproliferation transposition; mutant strain: Yaa | accelerated autoimmunity and lymphoproliferation transposition | accelerated autoimmunity and lymphoproliferation | EM:02279 | European Mouse Mutant Archive | EMMA | sperm | MGI:5494443, IMSR_HAR:3415 | 2026-07-24 10:29:43 | 0 | |||
|
B10ScSn.BXSB-(D1Mit33-D1Mit223) Chr YBXSB/MpJ/BjmjrH Resource Report Resource Website Issue |
RRID:IMSR_EM:02276 | Mus musculus | B10.Yaa.Bxs3(160-190) | gene symbol note: accelerated autoimmunity and lymphoproliferation transposition; mutant strain: Yaa | accelerated autoimmunity and lymphoproliferation transposition | accelerated autoimmunity and lymphoproliferation | EM:02276 | European Mouse Mutant Archive | EMMA | sperm | MGI:5494323, IMSR_HAR:3420 | 2026-07-24 10:29:43 | 0 | |||
|
B10ScSn.BXSB-(D1Mit303-D1Mit305) Chr YBXSB/MpJ/BjmjrH Resource Report Resource Website Issue |
RRID:IMSR_EM:02277 | Mus musculus | B10.Yaa.Bxs1(63-89) | gene symbol note: accelerated autoimmunity and lymphoproliferation transposition; mutant strain: Yaa | accelerated autoimmunity and lymphoproliferation transposition | accelerated autoimmunity and lymphoproliferation | EM:02277 | European Mouse Mutant Archive | EMMA | sperm | MGI:5494326, IMSR_HAR:3419 | 2026-07-24 10:29:43 | 0 | |||
|
B6.129P2-Apoetm1Unc/JArc Resource Report 1+ mentions Issue The record is no longer available at this source. |
RRID:IMSR_ARC:APOE | Mus musculus | gene symbol note: apolipoprotein A-I|apolipoprotein E; mutant strain|congenic strain: Apoa1|Apoe | apolipoprotein A-I|apolipoprotein E | targeted mutation 1; University of North Carolina | ARC:APOE | Animal Resources Centre | ARC | live | 2026-07-24 10:29:29 | 2 | |||||
|
B6.129-Tlr2tm1Aki/Obs Resource Report Resource Website 1+ mentions Issue |
RRID:IMSR_OBS:3 | Mus musculus |
TLR2 KO. B6.129P2-Tlr2 |
gene symbol note: toll-like receptor 2; mutant strain|congenic strain: Tlr2 | toll-like receptor 2 | targeted mutation 1; Shizuo Akira | OBS:3 | Oriental BioService, Inc. | OBS | embryo | 2026-07-24 10:29:28 | 2 | ||||
|
BALB/c-Rag2tm1Fwa Il2rg Resource Report Resource Website Issue Issue |
RRID:IMSR_BRGSF | Mus musculus |
C.Cg-Rag2 |
gene symbol note: recombination activating gene 2|FMS-like tyrosine kinase 3|signal-regulatory protein alpha|interleukin 2 receptor; gamma chain; coisogenic strain|mutant strain: Rag2|Flt3|Sirpa|Il2rg | recombination activating gene 2|FMS-like tyrosine kinase 3|signal-regulatory protein alpha|interleukin 2 receptor; gamma chain | targeted mutation 1; Frederick W Alt|targeted mutation 1; Ihor R Lemischka|unknown|targeted mutation 1; University of Cologne | BRGSF | genOway | GENO | live | 2026-07-24 10:29:28 | 0 | ||||
|
BALB/c.129P2-Tlr2tm1Aki/Obs Resource Report Resource Website 1+ mentions Issue |
RRID:IMSR_OBS:9 | Mus musculus |
C.129P2(B6)-Tlr2 |
gene symbol note: toll-like receptor 2; mutant strain|congenic strain: Tlr2 | toll-like receptor 2 | targeted mutation 1; Shizuo Akira | OBS:9 | Oriental BioService, Inc. | OBS | live | 2026-07-24 10:29:29 | 1 | ||||
|
BALB/c-Rag2tm1Fwa Il2rg Resource Report Resource Website Issue Issue |
RRID:IMSR_BRGSF-A2 | Mus musculus |
C.Cg-Rag2 |
gene symbol note: recombination activating gene 2|FMS-like tyrosine kinase 3|interleukin 2 receptor; gamma chain|signal-regulatory protein alpha|histocompatibility 2; D region|human major histocompatibility complex; class I; A2.1|beta-2 microglobulin; coisogenic strain|mutant strain: Rag2|Flt3|Il2rg|Sirpa|H2-D|HLA-A2.1|B2m | recombination activating gene 2|FMS-like tyrosine kinase 3|interleukin 2 receptor; gamma chain|signal-regulatory protein alpha|histocompatibility 2; D region|human major histocompatibility complex; class I; A2.1|beta-2 microglobulin | targeted mutation 1; Frederick W Alt|targeted mutation 1; Ihor R Lemischka|targeted mutation 1; University of Cologne|unknown|transgene insertion 1; Beatrice Perarnau | BRGSF-A2 | genOway | GENO | live | 2026-07-24 10:29:28 | 0 | ||||
|
C3H101H-Pax3Sp-2H/H Resource Report Resource Website Issue |
RRID:IMSR_EM:02535 | Mus musculus | gene symbol note: paired box 3; mutant strain: Pax3 | paired box 3 | splotch 2 Harwell | EM:02535 | European Mouse Mutant Archive | EMMA | embryo | MGI:3579063, IMSR_HAR:239 | 2026-07-24 10:29:46 | 0 | ||||
|
B6.129S-Tnftm1Gkl/Flmg Resource Report Resource Website Issue |
RRID:IMSR_EM:04790 | Mus musculus | Tnfalpha-/- | gene symbol note: tumor necrosis factor; mutant strain: Tnf | tumor necrosis factor | targeted mutation 1; George Kollias | EM:04790 | European Mouse Mutant Archive | EMMA | sperm | IMSR_EM:01969 | 2026-07-24 10:29:51 | 0 | |||
|
B6JOlaHsd.Cg-Cdkn2atm1Rdp/Cnbc Resource Report Resource Website 1+ mentions Issue |
RRID:IMSR_EM:04766 | Mus musculus |
Ink4a-Arf (-/-) null KO mice (P16 KO). Tyrp1<+>. B6.Cg-Cdkn2a |
gene symbol note: cyclin dependent kinase inhibitor 2A; mutant strain: Cdkn2a | cyclin dependent kinase inhibitor 2A | targeted mutation 1; Ronald DePinho | EM:04766 | European Mouse Mutant Archive | EMMA | embryo | 2026-07-24 10:29:50 | 1 | ||||
|
STOCK Cdkn2atm1Rdp Tg(Cnp-TVA.-lacZ)B8Ubc/Kctt Resource Report Resource Website Issue |
RRID:IMSR_EM:04997 | Mus musculus | Ctv-a Ink4a-Arf-/- | gene symbol note: transgene insertion B8; Uppsala University|cyclin dependent kinase inhibitor 2A; mutant strain: Tg(Cnp-TVA;-lacZ)B8Ubc|Cdkn2a | transgene insertion B8; Uppsala University|cyclin dependent kinase inhibitor 2A | transgene insertion B8; Uppsala University|targeted mutation 1; Ronald DePinho | EM:04997 | European Mouse Mutant Archive | EMMA | embryo | 2026-07-24 10:29:52 | 0 | ||||
|
C.Cg-Tg(Tek-cre)1Ywa/Cnbc Resource Report Resource Website Issue |
RRID:IMSR_EM:05243 | Mus musculus | Tie2 Cre Balb/c (backcross of Cg-Tg(Tek-cre)1Ywa/J - Jax). C.Cg-Tg(Tek-cre)1Ywa/JCnbc | gene symbol note: transgene insertion 1; Masashi Yanagisawa; mutant strain: Tg(Tek-cre)1Ywa | transgene insertion 1; Masashi Yanagisawa | transgene insertion 1; Masashi Yanagisawa | EM:05243 | European Mouse Mutant Archive | EMMA | embryo | 2026-07-24 10:29:54 | 0 | ||||
|
B6.129-Apoetm1Unc Apptm1Dbo/Mmjax Resource Report Resource Website Issue |
RRID:MMRRC_042049-JAX | Mus musculus | Research areas: Cardiovascular, Diabetes, Immunology and Inflammation, Models for Human Disease, Obesity; Mutation Type: Targeted Mutation ; Collection: | abnormal cochlea morphology [MP:0000031]| organ of Corti degeneration [MP:0000043]| abnormal stria vascularis morphology [MP:0000048]| increased bone mineral density [MP:0000062]| decreased bone mineral density [MP:0000063]| abnormal trabecular bone morphology [MP:0000130]| abnormal vertebrae morphology [MP:0000137]| abnormal circulating cholesterol level [MP:0000180]| increased circulating LDL cholesterol level [MP:0000182]| decreased circulating HDL cholesterol level [MP:0000186]| decreased hematocrit [MP:0000208]| increased monocyte cell number [MP:0000220]| decreased monocyte cell number [MP:0000223]| hypertension [MP:0000231]| abnormal blood flow velocity [MP:0000233]| macrocytosis [MP:0000248]| abnormal blood vessel physiology [MP:0000249]| echinocytosis [MP:0000256]| abnormal heart morphology [MP:0000266]| abnormal aorta morphology [MP:0000272]| enlarged heart [MP:0000274]| altered response to myocardial infarction [MP:0000343]| decreased hair follicle number [MP:0000379]| alopecia [MP:0000414]| sparse hair [MP:0000416]| abnormal femur morphology [MP:0000559]| abnormal liver morphology [MP:0000598]| amyloidosis [MP:0000604]| abnormal liver physiology [MP:0000609]| abnormal adrenal gland morphology [MP:0000639]| abnormal immune system morphology [MP:0000685]| enlarged spleen [MP:0000691]| enlarged lymph nodes [MP:0000702]| enlarged thymus [MP:0000709]| abnormal skin condition [MP:0001191]| thick skin [MP:0001200]| skin lesions [MP:0001212]| hyperkeratosis [MP:0001242]| abnormal dermal layer morphology [MP:0001243]| thick dermal layer [MP:0001245]| mixed cellular infiltration to dermis [MP:0001246]| decreased body length [MP:0001258]| increased body weight [MP:0001260]| obese [MP:0001261]| decreased body weight [MP:0001262]| abnormal retina morphology [MP:0001325]| dry eyes [MP:0001337]| Meibomian gland atrophy [MP:0001345]| increased anxiety-related response [MP:0001363]| abnormal stationary movement [MP:0001388]| abnormal locomotor behavior [MP:0001392]| abnormal response to new environment [MP:0001413]| decreased exploration in new environment [MP:0001417]| abnormal spatial learning [MP:0001463]| increased startle reflex [MP:0001488]| decreased startle reflex [MP:0001489]| abnormal kindling response [MP:0001499]| abnormal coat appearance [MP:0001510]| abnormal skeleton physiology [MP:0001533]| abnormal hematopoietic system physiology [MP:0001545]| abnormal lipid level [MP:0001547]| hyperlipidemia [MP:0001548]| increased circulating triglyceride level [MP:0001552]| increased circulating free fatty acid level [MP:0001554]| increased circulating HDL cholesterol level [MP:0001556]| hyperglycemia [MP:0001559]| anemia [MP:0001577]| cardiac hypertrophy [MP:0001625]| hypersecretion of corticosterone [MP:0001744]| increased circulating corticosterone level [MP:0001745]| abnormal immune system physiology [MP:0001790]| impaired macrophage phagocytosis [MP:0001798]| abnormal inflammatory response [MP:0001845]| heart inflammation [MP:0001853]| kidney inflammation [MP:0001859]| lung inflammation [MP:0001861]| vascular inflammation [MP:0001863]| abnormal lung volume [MP:0001942]| deafness [MP:0001967]| abnormal skin morphology [MP:0002060]| abnormal fear/anxiety-related behavior [MP:0002065]| increased circulating insulin level [MP:0002079]| premature death [MP:0002083]| abnormal lipid homeostasis [MP:0002118]| abnormal cardiovascular system morphology [MP:0002127]| abnormal kidney morphology [MP:0002135]| abnormal brain morphology [MP:0002152]| abnormal gland physiology [MP:0002164]| gliosis [MP:0002183]| abnormal artery morphology [MP:0002191]| neurodegeneration [MP:0002229]| abnormal pulmonary alveolus morphology [MP:0002270]| abnormal lymph node morphology [MP:0002339]| abnormal dendritic cell physiology [MP:0002376]| abnormal cell-mediated immunity [MP:0002421]| abnormal macrophage morphology [MP:0002446]| abnormal erythrocyte morphology [MP:0002447]| abnormal macrophage physiology [MP:0002451]| increased immunoglobulin level [MP:0002461]| abnormal neutrophil physiology [MP:0002463]| increased IgG level [MP:0002493]| increased IgM level [MP:0002494]| abnormal blood coagulation [MP:0002551]| hepatic steatosis [MP:0002628]| reticulocytosis [MP:0002640]| poikilocytosis [MP:0002643]| decreased circulating triglyceride level [MP:0002644]| abnormal sciatic nerve morphology [MP:0002651]| abnormal immune serum protein physiology [MP:0002723]| decreased circulating insulin level [MP:0002727]| abnormal thermal nociception [MP:0002733]| glomerulonephritis [MP:0002743]| dilated heart left ventricle [MP:0002753]| decreased vertical activity [MP:0002757]| abnormal retinal vasculature morphology [MP:0002792]| increased thigmotaxis [MP:0002797]| increased heart weight [MP:0002833]| increased systemic arterial blood pressure [MP:0002842]| decreased systemic arterial blood pressure [MP:0002843]| cochlear ganglion degeneration [MP:0002857]| increased growth rate [MP:0002865]| albuminuria [MP:0002871]| decreased hemoglobin content [MP:0002874]| increased insulin sensitivity [MP:0002891]| thick ventricular wall [MP:0002953]| increased urine protein level [MP:0002962]| increased liver weight [MP:0002981]| abnormal cytokine secretion [MP:0003009]| increased vasoconstriction [MP:0003025]| decreased myocardial infarction size [MP:0003038]| abnormal impulse conducting system conduction [MP:0003137]| cardiac fibrosis [MP:0003141]| abnormal tectorial membrane morphology [MP:0003149]| impaired muscle relaxation [MP:0003157]| increased cholesterol efflux [MP:0003192]| amyloid beta deposits [MP:0003329]| hypopituitarism [MP:0003348]| increased cardiac output [MP:0003394]| abnormal nervous system physiology [MP:0003633]| abnormal response/metabolism to endogenous compounds [MP:0003638]| abnormal axon extension [MP:0003651]| oxidative stress [MP:0003674]| xanthoma [MP:0003692]| increased autoantibody level [MP:0003725]| decreased autoantibody level [MP:0003726]| abnormal retinal inner nuclear layer morphology [MP:0003733]| abnormal bone structure [MP:0003795]| impaired macrophage chemotaxis [MP:0003799]| vascular smooth muscle hypoplasia [MP:0003814]| enhanced coordination [MP:0003858]| abnormal myelin sheath morphology [MP:0003871]| decreased macrophage cell number [MP:0003884]| abnormal ST segment [MP:0003897]| decreased kidney weight [MP:0003918]| abnormal lymphocyte physiology [MP:0003945]| abnormal cholesterol level [MP:0003947]| abnormal circulating lipid level [MP:0003949]| increased circulating VLDL triglyceride level [MP:0003975]| increased circulating phospholipid level [MP:0003980]| increased cholesterol level [MP:0003982]| decreased cholesterol level [MP:0003983]| arteriosclerosis [MP:0003991]| aortic dissection [MP:0004044]| abnormal coronary artery morphology [MP:0004111]| abnormal aortic arch morphology [MP:0004113]| increased compact bone thickness [MP:0004148]| increased renal tubule apoptosis [MP:0004153]| abnormal basilar membrane morphology [MP:0004308]| cochlear inner hair cell degeneration [MP:0004398]| cochlear outer hair cell degeneration [MP:0004404]| abnormal spiral modiolar artery morphology [MP:0004629]| spiral modiolar artery stenosis [MP:0004630]| increased anti-double stranded DNA antibody level [MP:0004762]| abnormal synaptic vesicle morphology [MP:0004769]| increased macrophage derived foam cell number [MP:0004778]| increased anti-nuclear antigen antibody level [MP:0004794]| increased susceptibility to systemic lupus erythematosus [MP:0004801]| increased mean systemic arterial blood pressure [MP:0004875]| decreased systemic vascular resistance [MP:0004879]| abnormal vascular wound healing [MP:0004883]| decreased adiponectin level [MP:0004893]| increased uterus weight [MP:0004904]| skin inflammation [MP:0004947]| increased spleen weight [MP:0004952]| abnormal osteoblast physiology [MP:0005006]| increased B cell number [MP:0005014]| increased T cell number [MP:0005015]| decreased T cell number [MP:0005018]| increased susceptibility to parasitic infection [MP:0005027]| abnormal thrombosis [MP:0005048]| decreased acute inflammation [MP:0005087]| decreased cardiac muscle contractility [MP:0005140]| increased circulating VLDL cholesterol level [MP:0005145]| decreased circulating VLDL cholesterol level [MP:0005146]| abnormal blood-brain barrier function [MP:0005167]| increased circulating cholesterol level [MP:0005178]| decreased circulating cholesterol level [MP:0005179]| glomerulosclerosis [MP:0005264]| abnormal cholesterol homeostasis [MP:0005278]| improved glucose tolerance [MP:0005292]| impaired glucose tolerance [MP:0005293]| abnormal circulating amino acid level [MP:0005311]| increased triglyceride level [MP:0005317]| abnormal enzyme/coenzyme level [MP:0005319]| abnormal renal glomerulus morphology [MP:0005325]| insulin resistance [MP:0005331]| abnormal gonadal fat pad morphology [MP:0005335]| atherosclerotic lesions [MP:0005338]| increased susceptibility to atherosclerosis [MP:0005339]| altered susceptibility to atherosclerosis [MP:0005340]| decreased susceptibility to atherosclerosis [MP:0005341]| abnormal bile salt homeostasis [MP:0005365]| vascular stenosis [MP:0005412]| abnormal circulating protein level [MP:0005416]| increased macrophage cell number [MP:0005425]| increased susceptibility to weight gain [MP:0005455]| vascular smooth muscle hyperplasia [MP:0005489]| abnormal eye electrophysiology [MP:0005551]| increased circulating creatinine level [MP:0005553]| increased circulating glucose level [MP:0005559]| decreased circulating glucose level [MP:0005560]| abnormal enzyme/coenzyme activity [MP:0005584]| increased vasodilation [MP:0005590]| decreased vasodilation [MP:0005591]| abnormal vascular smooth muscle morphology [MP:0005592]| abnormal vascular smooth muscle physiology [MP:0005595]| decreased susceptibility to type IV hypersensitivity reaction [MP:0005616]| decreased susceptibility to diet-induced obesity [MP:0005659]| decreased circulating leptin level [MP:0005668]| increased circulating leptin level [MP:0005669]| increased apoptosis [MP:0006042]| abnormal vascular endothelial cell morphology [MP:0006055]| decreased cerebral infarction size [MP:0006058]| increased cerebral infarction size [MP:0006060]| abnormal circulating homocysteine level [MP:0006076]| increased fat cell size [MP:0006094]| calcified artery [MP:0006133]| artery occlusion [MP:0006134]| increased systemic arterial systolic blood pressure [MP:0006144]| decreased systemic arterial systolic blood pressure [MP:0006264]| aortic aneurysm [MP:0006278]| abnormal T cell number [MP:0006387]| delayed cellular replicative senescence [MP:0008009]| impaired lipolysis [MP:0008033]| abnormal CD4-positive [MP:0008073]| alpha beta T cell number [MP:0008074]| increased CD4-positive [MP:0008075]| alpha beta T cell number [MP:0008079]| decreased CD4-positive [MP:0008090]| alpha beta T cell number [MP:0008143]| decreased CD8-positive [MP:0008174]| alpha-beta T cell number [MP:0008181]| increased T-helper 2 cell number [MP:0008182]| abnormal dendrite morphology [MP:0008217]| decreased follicular B cell number [MP:0008243]| increased marginal zone B cell number [MP:0008248]| decreased marginal zone B cell number [MP:0008288]| abnormal B cell activation [MP:0008289]| abnormal macrophage derived foam cell morphology [MP:0008389]| abnormal mononuclear phagocyte morphology [MP:0008406]| abnormal adrenal cortex morphology [MP:0008428]| abnormal adrenal medulla morphology [MP:0008511]| hypochromic macrocytic anemia [MP:0008515]| increased cellular sensitivity to hydrogen peroxide [MP:0008544]| abnormal spatial working memory [MP:0008553]| thin retinal inner nuclear layer [MP:0008561]| thin retinal outer nuclear layer [MP:0008566]| impaired olfaction [MP:0008567]| increased circulating tumor necrosis factor level [MP:0008577]| decreased tumor necrosis factor secretion [MP:0008596]| increased interferon-gamma secretion [MP:0008597]| decreased interferon-gamma secretion [MP:0008617]| increased circulating interferon-gamma level [MP:0008660]| increased circulating interleukin-6 level [MP:0008817]| decreased circulating interleukin-6 level [MP:0008916]| increased circulating interleukin-12 level [MP:0009278]| increased interleukin-10 secretion [MP:0009289]| hematoma [MP:0009346]| abnormal astrocyte physiology [MP:0009538]| abnormal bone marrow cell physiology [MP:0009763]| decreased epididymal fat pad weight [MP:0009764]| decreased trabecular bone thickness [MP:0009814]| abnormal synapse morphology [MP:0009862]| increased sensitivity to induced morbidity/mortality [MP:0009864]| decreased sensitivity to induced morbidity/mortality [MP:0009866]| increased prostaglandin level [MP:0009868]| abnormal aorta elastic tissue morphology [MP:0009873]| abnormal aorta endothelium morphology [MP:0009932]| abnormal aorta wall morphology [MP:0010210]| abnormal descending thoracic aorta morphology [MP:0010451]| abnormal aorta tunica media morphology [MP:0010483]| skin fibrosis [MP:0010574]| abnormal circulating cytokine level [MP:0010658]| kidney microaneurysm [MP:0010659]| aortic sinus aneurysm [MP:0010663]| aorta dilation [MP:0010724]| thoracic aorta aneurysm [MP:0010760]| abdominal aorta aneurysm [MP:0010868]| abnormal brachiocephalic trunk morphology [MP:0010869]| thick interventricular septum [MP:0010879]| abnormal macrophage chemotaxis [MP:0010895]| increased bone trabecula number [MP:0010922]| decreased bone trabecula number [MP:0010933]| decreased trabecular bone volume [MP:0010935]| increased lung compliance [MP:0010950]| alveolitis [MP:0011086]| decreased trabecular bone connectivity density [MP:0011231]| increased airway resistance [MP:0011294]| abnormal lung hysteresivity [MP:0011309]| postnatal lethality [MP:0011339]| incomplete penetrance [MP:0011353]| abnormal vitamin E level [MP:0011368]| renal glomerulus hypertrophy [MP:0011430]| abnormal kidney arterial blood vessel morphology [MP:0011477]| abnormal glomerular mesangium morphology [MP:0011508]| expanded mesangial matrix [MP:0011509]| increased kidney apoptosis [MP:0011561]| mesangiolysis [MP:0011567]| abnormal urine nucleoside level [MP:0011572]| glomerular capillary thrombosis [MP:0011578]| dilated glomerular capillary [MP:0011581]| renal glomerulus lipidosis [MP:0011599]| increased renal glomerulus lobularity [MP:0011939]| abnormal aorta bulb morphology [MP:0011941]| increased lipoprotein lipase activity [MP:0011951]| increased triglyceride lipase activity [MP:0011967]| increased phosphatidylcholine-sterol O-acyltransferase activity [MP:0012307]| increased food intake [MP:0012335]| increased fluid intake [MP:0013022]| increased cardiac stroke volume [MP:0014169]| increased or absent threshold for auditory brainstem response [MP:0020253]| impaired spatial learning [MP:0020408]| increased circulating homocysteine level [MP:0020519]| weakness [MP:0000746]| decreased brain size [MP:0000774]| small cerebellum [MP:0000852]| Purkinje cell degeneration [MP:0000876]| demyelination [MP:0000921]| abnormal neuromuscular synapse morphology [MP:0001053]| decreased body weight [MP:0001262]| weight loss [MP:0001263]| decreased body size [MP:0001265]| ataxia [MP:0001393]| hypoactivity [MP:0001402]| impaired coordination [MP:0001405]| spinning [MP:0001411]| abnormal spatial learning [MP:0001463]| impaired righting response [MP:0001523]| intracerebral hemorrhage [MP:0001916]| reduced fertility [MP:0001921]| premature death [MP:0002083]| gliosis [MP:0002183]| abnormal long term potentiation [MP:0002207]| abnormal active avoidance behavior [MP:0002798]| abnormal neuron morphology [MP:0002882]| abnormal locomotor activation [MP:0003313]| astrocytosis [MP:0003354]| pallor [MP:0003717]| head tilt [MP:0005191]| hematoma [MP:0008817]| absent gastric milk in neonates [MP:0009546]| abnormal neuron differentiation [MP:0009937]| decreased grip strength [MP:0010053]| increased brain cholesterol level [MP:0010162]| postnatal lethality [MP:0011085]| complete penetrance [MP:0011086]| postnatal lethality [MP:0011110]| incomplete penetrance [MP:0020408] | |Apoe|App| | 042049-JAX | Targeted Mutation | Mutant Mouse Resource and Research Center (MMRRC) | MMRRC | MMRRC_42049-JAX, MMRRC_042049, MMRRC_4249 | 2026-07-25 09:43:11 | 0 | ||||
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NOD.Cg-Cd28tm1Mak Cd40tm1Kik Ifngtm1Ts H2h4/HbmMmmh Resource Report Resource Website 1+ mentions Issue |
RRID:MMRRC_037143-MU | Mus musculus | Research areas: Immunology and Inflammation; Mutation Type: Targeted Mutation ; Collection: Mullen | increased leukocyte cell number [MP:0000218]| increased monocyte cell number [MP:0000220]| extramedullary hematopoiesis [MP:0000240]| increased granulocyte number [MP:0000322]| abnormal spleen morphology [MP:0000689]| enlarged spleen [MP:0000691]| abnormal lymph node size [MP:0000701]| enlarged lymph nodes [MP:0000702]| increased body weight [MP:0001260]| decreased body weight [MP:0001262]| increased metastatic potential [MP:0001272]| abnormal response to new environment [MP:0001413]| altered susceptibility to infection [MP:0001793]| abnormal humoral immune response [MP:0001800]| decreased IgG level [MP:0001805]| decreased IgM level [MP:0001806]| decreased IgA level [MP:0001807]| abnormal inflammatory response [MP:0001845]| increased inflammatory response [MP:0001846]| brain inflammation [MP:0001847]| kidney inflammation [MP:0001859]| liver inflammation [MP:0001860]| lung inflammation [MP:0001861]| stomach inflammation [MP:0001873]| decreased inflammatory response [MP:0001876]| abnormal lactation [MP:0001882]| mammary gland alveolar hyperplasia [MP:0001884]| decreased litter size [MP:0001935]| abnormal lung volume [MP:0001942]| increased airway responsiveness [MP:0001952]| emphysema [MP:0001958]| increased B cell derived lymphoma incidence [MP:0002023]| increased T cell derived lymphoma incidence [MP:0002024]| increased lung adenocarcinoma incidence [MP:0002027]| increased sarcoma incidence [MP:0002032]| increased carcinoma incidence [MP:0002038]| increased pituitary adenoma incidence [MP:0002041]| decreased tumor incidence [MP:0002052]| premature death [MP:0002083]| abnormal spleen size [MP:0002224]| abnormal pulmonary alveolus morphology [MP:0002270]| decreased airway responsiveness [MP:0002335]| abnormal lymph node cortex morphology [MP:0002343]| abnormal lymph node primary follicle morphology [MP:0002345]| abnormal lymph node secondary follicle morphology [MP:0002346]| abnormal spleen red pulp morphology [MP:0002356]| abnormal spleen white pulp morphology [MP:0002357]| abnormal dendritic cell physiology [MP:0002376]| increased susceptibility to bacterial infection [MP:0002412]| increased susceptibility to viral infection [MP:0002418]| abnormal adaptive immunity [MP:0002420]| altered susceptibility to autoimmune disorder [MP:0002425]| abnormal macrophage physiology [MP:0002451]| abnormal dendritic cell antigen presentation [MP:0002455]| abnormal B cell physiology [MP:0002459]| decreased immunoglobulin level [MP:0002460]| increased immunoglobulin level [MP:0002461]| abnormal immunoglobulin level [MP:0002490]| decreased IgE level [MP:0002492]| increased IgE level [MP:0002497]| abnormal type IV hypersensitivity reaction [MP:0002534]| glomerulonephritis [MP:0002743]| decreased vertical activity [MP:0002757]| albuminuria [MP:0002871]| increased circulating alanine transaminase level [MP:0002941]| abnormal cytokine secretion [MP:0003009]| abnormal redox activity [MP:0003186]| small intestinal inflammation [MP:0003306]| abnormal tumor morphology [MP:0003448]| increased fear-related response [MP:0003459]| abnormal pancreatic beta cell physiology [MP:0003562]| increased ovarian carcinoma incidence [MP:0003579]| increased autoantibody level [MP:0003725]| decreased autoantibody level [MP:0003726]| abnormal nitric oxide homeostasis [MP:0003957]| abnormal lung vasculature morphology [MP:0004007]| abnormal maternal decidual layer morphology [MP:0004256]| decreased length of allograft survival [MP:0004752]| decreased anti-nuclear antigen antibody level [MP:0004795]| decreased anti-double stranded DNA antibody level [MP:0004798]| increased susceptibility to experimental autoimmune encephalomyelitis [MP:0004799]| decreased susceptibility to systemic lupus erythematosus [MP:0004802]| decreased susceptibility to autoimmune diabetes [MP:0004804]| abnormal immune tolerance [MP:0005000]| increased eosinophil cell number [MP:0005011]| increased lymphocyte cell number [MP:0005013]| increased T cell number [MP:0005015]| abnormal response to infection [MP:0005025]| decreased susceptibility to parasitic infection [MP:0005026]| increased susceptibility to parasitic infection [MP:0005027]| abnormal MHC II cell surface expression on macrophages [MP:0005040]| impaired natural killer cell mediated cytotoxicity [MP:0005070]| abnormal cytotoxic T cell physiology [MP:0005078]| decreased double-negative T cell number [MP:0005089]| cachexia [MP:0005150]| abnormal response to injury [MP:0005164]| decreased susceptibility to injury [MP:0005166]| abnormal renal glomerulus morphology [MP:0005325]| atherosclerotic lesions [MP:0005338]| decreased susceptibility to autoimmune disorder [MP:0005351]| abnormal Langerhans cell physiology [MP:0005362]| increased susceptibility to fungal infection [MP:0005399]| abnormal skin physiology [MP:0005501]| corneal vascularization [MP:0005542]| decreased circulating creatinine level [MP:0005554]| increased blood urea nitrogen level [MP:0005565]| decreased susceptibility to type IV hypersensitivity reaction [MP:0005616]| increased susceptibility to type IV hypersensitivity reaction [MP:0005617]| abnormal response to transplant [MP:0005671]| abnormal mammary gland growth during pregnancy [MP:0006269]| increased NK T cell number [MP:0008039]| abnormal uterine NK cell morphology [MP:0008054]| increased CD4-positive [MP:0008074]| alpha beta T cell number [MP:0008078]| increased CD8-positive [MP:0008135]| alpha-beta T cell number [MP:0008466]| small Peyer's patches [MP:0008474]| enlarged mesenteric lymph nodes [MP:0008496]| absent spleen germinal center [MP:0008497]| decreased IgG2a level [MP:0008498]| decreased IgG2b level [MP:0008499]| decreased IgG3 level [MP:0008523]| increased IgG1 level [MP:0008567]| absent lymph node germinal center [MP:0008596]| decreased interferon-gamma secretion [MP:0008660]| increased circulating interleukin-6 level [MP:0008661]| increased interleukin-10 secretion [MP:0008663]| decreased interleukin-10 secretion [MP:0008681]| increased interleukin-12 secretion [MP:0008687]| increased interleukin-17 secretion [MP:0008699]| increased interleukin-2 secretion [MP:0008702]| increased interleukin-4 secretion [MP:0008713]| increased interleukin-5 secretion [MP:0008770]| abnormal cytokine level [MP:0008828]| decreased survivor rate [MP:0008874]| abnormal lymph node cell ratio [MP:0009099]| decreased physiological sensitivity to xenobiotic [MP:0009246]| abnormal uterine NK cell physiology [MP:0009336]| pale spleen [MP:0009394]| increased splenocyte proliferation [MP:0009419]| increased uterine NK cell number [MP:0009643]| skeletal muscle fibrosis [MP:0009763]| abnormal urine homeostasis [MP:0009766]| increased sensitivity to induced morbidity/mortality [MP:0009788]| increased sensitivity to xenobiotic induced morbidity/mortality [MP:0009791]| increased susceptibility to bacterial infection induced morbidity/mortality [MP:0009828]| increased susceptibility to viral infection induced morbidity/mortality [MP:0010210]| increased tumor latency [MP:0010308]| abnormal circulating cytokine level [MP:0010574]| decreased tumor latency [MP:0010639]| aorta dilation [MP:0010659]| altered tumor pathology [MP:0010740]| abdominal aorta aneurysm [MP:0010750]| abnormal dendritic cell chemotaxis [MP:0010751]| increased susceptibility to parasitic infection induced morbidity/mortality [MP:0010760]| decreased susceptibility to parasitic infection induced morbidity/mortality [MP:0010766]| abnormal macrophage chemotaxis [MP:0011086]| abnormal NK cell physiology [MP:0011320]| postnatal lethality [MP:0011427]| incomplete penetrance [MP:0012431]| abnormal glomerular capillary morphology [MP:0013239]| mesangial cell hyperplasia [MP:0013590]| increased lymphoma incidence [MP:0030466]| decreased bone mineral density [MP:0000063]| decreased neutrophil cell number [MP:0000222]| enlarged spleen [MP:0000691]| enlarged lymph nodes [MP:0000702]| abnormal humoral immune response [MP:0001800]| decreased IgA level [MP:0001807]| no abnormal phenotype detected [MP:0002169]| abnormal thymus medulla morphology [MP:0002375]| abnormal dendritic cell physiology [MP:0002376]| increased susceptibility to bacterial infection [MP:0002412]| abnormal B cell physiology [MP:0002459]| decreased immunoglobulin level [MP:0002460]| decreased IgE level [MP:0002492]| glomerulonephritis [MP:0002743]| increased urine protein level [MP:0002962]| increased anti-double stranded DNA antibody level [MP:0004762]| abnormal class switch recombination [MP:0004816]| decreased B cell number [MP:0005017]| decreased susceptibility to type II hypersensitivity reaction [MP:0005612]| decreased cerebral infarction size [MP:0006058]| increased follicular B cell number [MP:0008173]| absent germinal center B cells [MP:0008179]| increased marginal zone B cell number [MP:0008181]| increased transitional stage B cell number [MP:0008189]| abnormal B cell activation [MP:0008217]| absent spleen germinal center [MP:0008474]| decreased IgG1 level [MP:0008495]| decreased IgG2a level [MP:0008496]| decreased IgG2b level [MP:0008497]| decreased IgG3 level [MP:0008498]| abnormal thymus epithelium morphology [MP:0009544]| decreased platelet aggregation [MP:0009549]| decreased trabecular bone mass [MP:0010873]| decreased compact bone mass [MP:0010962]| renal glomerular immunoglobulin deposits [MP:0020519]| abnormal cytokine secretion [MP:0003009]| thyroid inflammation [MP:0003504]| insulitis [MP:0004031]| decreased susceptibility to autoimmune diabetes [MP:0004804]| periinsulitis [MP:0005580]| decreased physiological sensitivity to xenobiotic [MP:0008874]| abnormal esophageal epithelium morphology [MP:0000468]| enlarged thymus [MP:0000709]| increased activated T cell number [MP:0001829]| brain inflammation [MP:0001847]| increased T cell derived lymphoma incidence [MP:0002024]| abnormal T cell differentiation [MP:0002145]| abnormal lymphopoiesis [MP:0002401]| decreased immunoglobulin level [MP:0002460]| abnormal cytokine secretion [MP:0003009]| esophageal inflammation [MP:0003278]| insulitis [MP:0004031]| increased length of allograft survival [MP:0004751]| decreased susceptibility to experimental autoimmune encephalomyelitis [MP:0004800]| increased susceptibility to autoimmune diabetes [MP:0004803]| abnormal class switch recombination [MP:0004816]| abnormal regulatory T cell physiology [MP:0004946]| decreased regulatory T cell number [MP:0004974]| abnormal T cell clonal deletion [MP:0005002]| increased eosinophil cell number [MP:0005011]| increased susceptibility to parasitic infection [MP:0005027]| abnormal cytotoxic T cell physiology [MP:0005078]| decreased cytotoxic T cell cytolysis [MP:0005079]| decreased T cell proliferation [MP:0005095]| increased T cell proliferation [MP:0005348]| abnormal CD4-positive [MP:0005463]| alpha-beta T cell physiology [MP:0005465]| abnormal T-helper 1 physiology [MP:0005466]| abnormal T-helper 2 physiology [MP:0005596]| increased susceptibility to type I hypersensitivity reaction [MP:0005671]| abnormal response to transplant [MP:0006413]| increased T cell apoptosis [MP:0008049]| increased memory T cell number [MP:0008074]| increased CD4-positive [MP:0008078]| alpha beta T cell number [MP:0008192]| increased CD8-positive [MP:0008482]| alpha-beta T cell number [MP:0008495]| abnormal germinal center B cell physiology [MP:0008496]| decreased spleen germinal center number [MP:0008497]| decreased IgG1 level [MP:0008500]| decreased IgG2a level [MP:0008566]| decreased IgG2b level [MP:0008567]| increased IgG2a level [MP:0008578]| increased interferon-gamma secretion [MP:0008603]| decreased interferon-gamma secretion [MP:0008687]| decreased circulating interferon-gamma level [MP:0008688]| decreased circulating interleukin-4 level [MP:0008699]| increased interleukin-2 secretion [MP:0008700]| decreased interleukin-2 secretion [MP:0008747]| increased interleukin-4 secretion [MP:0009335]| decreased interleukin-4 secretion [MP:0010268]| abnormal T cell anergy [MP:0010766] | Cd28||Ifng||Cd40||| | 037143-MU | Targeted Mutation | Mutant Mouse Resource and Research Center (MMRRC) | MMRRC | MMRRC_37143-MU, MMRRC_037143, MMRRC_37143 | 2026-07-25 09:42:11 | 1 |
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