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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.

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Resource Name Proper Citation Abbreviations Resource Type Description Keywords Resource Relationships Related Condition Funding Defining Citation Availability Specification URL Alternate IDs Alternate URLs Old URLs Parent Organization Resource ID Synonyms Record Last Update Mentions Count
SamSPECTRAL
 
Resource Report
Resource Website
1+ mentions
SamSPECTRAL (RRID:SCR_001858) software resource Software that identifies cell population in flow cytometry data. It demonstrates significant advantages in proper identification of populations with non-elliptical shapes, low density populations close to dense ones, minor subpopulations of a major population and rare populations. It samples large data such that spectral clustering is possible while preserving density information in edge weights. More specifically, given a matrix of coordinates as input, SamSPECTRAL first builds the communities to sample the data points. Then, it builds a graph and after weighting the edges by conductance computation, the graph is passed to a classic spectral clustering algorithm to find the spectral clusters. The last stage of SamSPECTRAL is to combine the spectral clusters. The resulting connected components estimate biological cell populations in the data sample. software package, mac os x, unix/linux, windows, r, cell biology, clustering, flow cytometry, stem cell, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: Bioconductor
Cancer, HIV PMID:20667133 Free, Available for download, Freely available OMICS_05638, biotools:samspectral https://bio.tools/samspectral SCR_001858 SamSPECTRAL - Identifies cell population in flow cytometry data 2026-07-25 12:05:11 4
CQN
 
Resource Report
Resource Website
1+ mentions
CQN (RRID:SCR_001786) CQN software resource A normalization tool for RNA-Seq data, implementing the conditional quantile normalization method. rna-seq, differential expression, preprocessing, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: Bioconductor
has parent organization: Johns Hopkins Bloomberg School of Public Health; Maryland; USA
PMID:22285995 Free, Available for download, Freely available OMICS_01949, biotools:cqn https://bio.tools/cqn SCR_001786 Conditional Quantile Normalization 2026-07-25 12:05:09 6
ADaCGH2
 
Resource Report
Resource Website
ADaCGH2 (RRID:SCR_001981) software resource Software for analysis and plotting of array comparative genomic hybridization (CGH) data. It allows usage of Circular Binary Segementation, wavelet-based smoothing (both as in Liu et al., and HaarSeg as in Ben-Yaacov and Eldar), HMM, BioHMM, GLAD, CGHseg. Most computations are parallelized (either via forking or with clusters, including MPI and sockets clusters) and use ff for storing data. standalone software, mac os x, unix/linux, windows, r, copy number variant, microarray, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: Bioconductor
PMID:24532724 Free, Available for download, Freely available biotools:adacgh2, OMICS_03697 https://bio.tools/adacgh2 SCR_001981 ADaCGH2 - Analysis of big data from aCGH experiments using parallel computing and ff objects 2026-07-25 12:05:17 0
PurBayes
 
Resource Report
Resource Website
10+ mentions
PurBayes (RRID:SCR_002068) software resource An MCMC-based algorithm that uses next-generation sequencing data to estimate tumor purity and clonality for paired tumor-normal data. software package, unix/linux, mac os x, windows, r, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: CRAN
PMID:23749958 Free, Available for download, Freely available biotools:purbayes, OMICS_03561 https://bio.tools/purbayes http://cran.r-project.org/web/packages/PurBayes/ SCR_002068 PurBayes: Bayesian Estimation of Tumor Purity and Clonality 2026-07-25 12:05:19 10
RAREMETAL
 
Resource Report
Resource Website
10+ mentions
RAREMETAL (RRID:SCR_003573) RAREMETAL software resource A software program that facilitates the meta-analysis of rare variants from genotype arrays or sequencing. bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: University of Michigan; Ann Arbor; USA
PMID:24894501 biotools:raremetal, OMICS_00243 https://bio.tools/raremetal SCR_003573 2026-07-25 12:05:41 22
SLIQ
 
Resource Report
Resource Website
1+ mentions
SLIQ (RRID:SCR_005003) SLIQ software resource Software for simple linear inequalities based Mate-Pair reads filtering and scaffolding. A set of simple linear inequalities (SLIQ) derived from the geometry of contigs on the line that can be used to predict the relative positions and orientations of contigs from individual mate pair reads and thus produce a contig digraph. The SLIQ inequalities can also filter out unreliable mate pairs and can be used as a pre-processing step for any scaffolding algorithm. This tool filters mate pairs and then produces a Directed Contig Graph (contig diGraph). Also provided is a Naive scaffolder that can then produce scaffolds out of the contig diGraph. python, scaffolding, contig position, contig orientation, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: Rutgers University; New Jersey; USA
PMID:23057825 biotools:sliq, OMICS_00048 https://bio.tools/sliq SCR_005003 Simple linear inequalities, SLiQ: Simple linear inequalities based Mate-Pair reads filtering and scaffolding 2026-07-25 12:05:58 3
SOPRA
 
Resource Report
Resource Website
10+ mentions
SOPRA (RRID:SCR_005035) SOPRA software resource Software tool to exploit the mate pair/paired-end information for assembly of short reads from high throughput sequencing platforms, e.g. Illumina and SOLiD. bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: Rutgers University; New Jersey; USA
PMID:20576136 Acknowledgement requested biotools:sopra, OMICS_00049 https://bio.tools/sopra SCR_005035 SOPRA - Statistical Optimization of Paired Read Assembly, Statistical Optimization of Paired Read Assembly 2026-07-25 12:05:57 20
SSPACE
 
Resource Report
Resource Website
100+ mentions
SSPACE (RRID:SCR_005056) SSPACE software resource A stand-alone software program for scaffolding pre-assembled contigs using paired-read data. Main features are: a short runtime, multiple library input of paired-end and/or mate pair datasets and possible contig extension with unmapped sequence reads. scaffolding, contig, genome, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
PMID:21149342
DOI:10.1093/bioinformatics/btq683
GNU General Public License, Registration required biotools:sspace, OMICS_00050 https://bio.tools/sspace, https://sources.debian.org/src/sspace/ SCR_005056 2026-07-25 12:05:58 426
MBCluster.Seq
 
Resource Report
Resource Website
1+ mentions
MBCluster.Seq (RRID:SCR_005079) MBCluster.Seq software resource Software to cluster genes based on Poisson or Negative-Binomial model for RNA-Seq or other digital gene expression (DGE) data. bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
PMID:24191069 GNU General Public License, >/=v3 OMICS_01417, biotools:mbcluster.seq https://bio.tools/mbcluster.seq SCR_005079 MBCluster.Seq: Model-Based Clustering for RNA-seq Data 2026-07-25 12:05:58 1
GRASS
 
Resource Report
Resource Website
50+ mentions
GRASS (RRID:SCR_005071) GRASS software resource A generic algorithm for scaffolding next-generation sequencing assemblies. next-generation sequencing, scaffolding, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
PMID:22492642 GNU General Public License, v3 biotools:GRASS, OMICS_00043 https://bio.tools/GRASS SCR_005071 GRASS: a generic algorithm for scaffolding next-generation sequencing assemblies, GeneRic ASembly Scaffolder 2026-07-25 12:05:58 89
G-BLASTN
 
Resource Report
Resource Website
G-BLASTN (RRID:SCR_005062) G-BLASTN software resource A GPU-accelerated nucleotide alignment tool based on the widely used NCBI-BLAST. It can produce exactly the same results as NCBI-BLAST, and it also has very similar user commands. It also supports a pipeline mode, which can fully utilize the GPU and CPU resources when handling a batch of medium to large sized queries. parallel computation 4, blast, alignment, nucleotide, gpu, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
is related to: NCBI BLAST
has parent organization: Hong Kong Baptist University; Hong Kong; China
has parent organization: SourceForge
Hong Kong Baptist University; Hong Kong; China FRG2/11-12/158;
NVIDIA
PMID:24463183 Free OMICS_02263, biotools:g-blastn http://sourceforge.net/projects/gblastn/, https://bio.tools/g-blastn SCR_005062 2026-07-25 12:06:00 0
VFS
 
Resource Report
Resource Website
1+ mentions
VFS (RRID:SCR_005138) VFS software resource A versatile high-throughput sequencing (HTS) tool for discovering viral integration events and reconstruct fusion transcripts at single-base resolution. It combines soft-clipping information, read-pair analysis, and targeted de novo assembly to discover and annotate viral-human fusion events. A simple yet effective empirical statistical model is used to evaluate the quality of fusion breakpoints. Minimal user defined parameters are required. ubuntu, debian, high-throughput sequencing, virus, reconstruct, fusion transcript, transcript, integration, fusion, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: SourceForge
has parent organization: Chinese University of Hong Kong; Hong Kong; China
PMID:23314323 GNU General Public License, v3 OMICS_00224, biotools:viralfusionseq https://bio.tools/viralfusionseq SCR_005138 ViralFusionSeq, ViralFusionSeq (VFS) 2026-07-25 12:06:00 1
MMAPPR
 
Resource Report
Resource Website
1+ mentions
MMAPPR (RRID:SCR_005092) MMAPPR software resource A software analysis pipeline for mapping mutations using RNA-seq that works without parental strain information, without the requirement of a pre-existing snp map of the organism, and without erroneous assumptions that recombination occurs at the same frequency across the genome. In addition, it compensates for the considerable amount of noise in RNA-seq datasets and simultaneously identifies the region where the mutation lies and generates a list of putative coding region mutations in the linked genomic segment. MMAPPR can utilize RNA-seq datasets from isolated tissues or whole organisms that are often generated for phenotypic analysis and gene network analysis in novel mutants. mutation, rna-seq, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: University of Utah; Utah; USA
PMID:23299975 Acknowledgement requested OMICS_01361, biotools:mmappr https://bio.tools/mmappr SCR_005092 Mutation Mapping Analysis Pipeline for Pooled RNA-seq 2026-07-25 12:06:01 7
FusionMap
 
Resource Report
Resource Website
50+ mentions
FusionMap (RRID:SCR_005242) FusionMap software resource An efficient fusion aligner which aligns reads spanning fusion junctions directly to the genome without prior knowledge of potential fusion regions. It detects and characterizes fusion junctions at base-pair resolution. FusionMap can be applied to detect fusion junctions in both single- and paired-end dataset from either gDNA-Seq or RNA-Seq studies. FusionMap runs under both Windows and Linux (requiring MONO) environments. Although it can run on 32 bit machine, it is recommended to run on 64-bit machine with 8GB RAM or more. If you have an ArrayStudio License, you can run the fusion detection easily through its GUI. windows, linux, c#, fusion gene, next-generation sequencing, gene, reference indexing, read filtering, fusion alignment, reporting, alignment, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
PMID:21593131 Free, Non-commercial biotools:fusionmap, OMICS_00316 https://bio.tools/fusionmap SCR_005242 2026-07-25 12:06:00 88
rQuant
 
Resource Report
Resource Website
1+ mentions
rQuant (RRID:SCR_005150) rQuant software resource Software for quantitative detection of alternative transcripts with RNA-Seq data. The method, based on quadratic programming, estimates biases introduced by experimental settings and is thus a powerful tool to reveal and quantify novel (alternative) transcripts. bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
is related to: Galaxy
PMID:20551130 biotools:rquant.web, OMICS_01286 https://bio.tools/rquant.web SCR_005150 rQuant: quantitative detection of alternative transcripts with RNA-Seq data 2026-07-25 12:05:59 1
ShoRAH
 
Resource Report
Resource Website
10+ mentions
ShoRAH (RRID:SCR_005211) ShoRAH software resource A software package that allows for inference about the structure of a population from a set of short sequence reads as obtained from ultra-deep sequencing of a mixed sample. The package contains programs that support mapping of reads to a reference genome, correcting sequencing errors by locally clustering reads in small windows of the alignment, reconstructing a minimal set of global haplotypes that explain the reads, and estimating the frequencies of the inferred haplotypes. linux, mac os x, windows, next-generation sequencing, c++, python, perl, structure, population, short sequence read, haplotype, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: ETH Zurich; Zurich; Switzerland
PMID:21521499 GNU General Public License, v3 biotools:shorah, OMICS_00231 https://bio.tools/shorah SCR_005211 Short Reads Assembly into Haplotypes, ShoRAH - Short Reads Assembly into Haplotypes 2026-07-25 12:06:03 35
V-Phaser 2
 
Resource Report
Resource Website
1+ mentions
V-Phaser 2 (RRID:SCR_005212) V-Phaser 2 software resource A software tool to call variants in genetically heterogeneous populations from ultra-deep sequence data. It combines information regarding the covariation (i.e. phasing) between observed variants to increase sensitivity and an expectation maximization algorithm that iteratively recalibrates base quality scores to increase specificity. V-Phaser can reliably detect rare variants in diverse populations that occur at frequencies of <1%. V-Phaser 2 is a complete rewrite of the original V-Phaser. It contains a new model for length polymorphisms (indels) and incorporates paired end read information in its phasing model. The data access and probability computation sections of the code have also been highly optimized, resulting in substantial improvements in running time and memory usage. variant, polymorphism, indel, virus, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: Broad Institute
NIAID PMID:24088188 Free for academic use, Non-commercial, Http://www.broadinstitute.org/scientific-community/science/projects/viral-genomics/viral-genomics-software-license-v-phaser-2 biotools:v-phaser, OMICS_00232 https://bio.tools/v-phaser SCR_005212 2026-07-25 12:06:00 2
RNA-eXpress
 
Resource Report
Resource Website
1+ mentions
RNA-eXpress (RRID:SCR_005167) RNA-eXpress software resource Software designed as a user friendly solution to extract and annotate biologically important transcripts from next generation RNA sequencing data. bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: Monash University; Melbourne; Australia
PMID:23396121 Acknowledgement requested, Non-Profit biotools:rna-express, OMICS_01285 https://bio.tools/rna-express SCR_005167 2026-07-25 12:05:59 5
SAMtools/BCFtools
 
Resource Report
Resource Website
500+ mentions
SAMtools/BCFtools (RRID:SCR_005227) BCFtools software resource Provide various utilities for manipulating alignments in the SAM format, including sorting, merging, indexing and generating alignments in a per-position format. snp, indel, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: SAMTOOLS
DOI:10.1101/090811 biotools:bcftools, OMICS_13458 https://bio.tools/bcftools, https://sources.debian.org/src/bcftools/ SCR_005227 2026-07-25 12:06:03 904
ORMAN
 
Resource Report
Resource Website
1+ mentions
ORMAN (RRID:SCR_005188) ORMAN software resource A software tool for resolving multi-mappings within an RNA-Seq SAM file. bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: SourceForge
PMID:24130305 OMICS_01284, biotools:orman https://bio.tools/orman SCR_005188 ORMAN : Optimal Resolution of Ambiguous RNA-Seq Multi-mappings in the Presence of Novel Isoforms 2026-07-25 12:06:00 4

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