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Proper Citation: RRID:MGI:3047403
Description: Allele Detail: Targeted This is a legacy resource.
Species: Mus musculus
Notes: Allele Detail: Targeted This is a legacy resource.
Phenotype: abnormal colon morphology, abnormal immune system physiology, weight loss, abnormal immune system morphology, increased interferon-gamma secretion, increased single-positive T cell number, abnormal digestive system physiology, lethality during fetal growth through weaning, complete penetrance, increased intestinal adenocarcinoma incidence, abnormal colon morphology, colitis, increased T cell proliferation, increased T cell number, increased granulocyte number, abnormal cytokine secretion, increased circulating interleukin-5 level, abnormal neutrophil physiology, increased circulating interferon-gamma level, increased circulating interleukin-4 level, increased immunoglobulin level, intestinal ulcer, increased tumor necrosis factor secretion, increased susceptibility to parasitic infection, abnormal cytokine level, megacolon, peritoneal inflammation, increased inflammatory response, premature death, postnatal growth retardation, increased interleukin-2 secretion, increased physiological sensitivity to xenobiotic, abnormal large intestine morphology, abnormal response/metabolism to endogenous compounds, decreased body weight, decreased physiological sensitivity to xenobiotic, increased IgA level, increased IgG level, abnormal large intestine crypts of Lieberkuhn morphology, large intestinal inflammation
Affected Gene: Gnai2
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Source: Integrated Animals
Source Database: MGI, Mouse Genome Informatics MGI
