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Children's Hospital of Philadelphia CHOP Clinical Vector Characterization Core Facility (RRID:SCR_028402)Copy Citation Copied
URL: https://chop.ilab.agilent.com/sc/4962/clinical-vector-core/?tab=about
Proper Citation: Children's Hospital of Philadelphia CHOP Clinical Vector Characterization Core Facility (RRID:SCR_028402)
Description: Core provides manufacturing of clinical and pre-clinical Adeno-Associated Virus (AAV) vectors of serotypes 1, 2, 5, 6, 8, 9, and Lentivirus (LV) vectors. Novel or modified serotypes will require development prior to scale-up. Products for clinical use are manufactured in compliance with Current Good Manufacturing Practices (cGMP) for Phase 1 and 2 clinical trials. To support pre-clinical work, including pharmacology and toxicology studies, core offers products manufactured using a GMP-comparable process. Research-grade products for proof-of- principle and bridging studies are also offered.Core Facility uses a patented vector production technology and a highly efficient purification process that uses combined column and gradient centrifugation-based process steps. This system has manufactured clinical-grade AAV vectors. Prior to the final release of the clinical vectors, the vector product is subjected to numerous tests to ensure quality. Core also provides federal regulatory documentation and necessary certifications.
Synonyms: Clinical Vector Characterization
Resource Type: access service resource, service resource, core facility
Keywords: ABRF, manufacturing of clinical and pre-clinical viruses, Adeno-Associated Virus, Lentivirus, patented vector production technology,
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Childrens Hospital of Philadelphia - Research Institute; Pennsylvania; USA |
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