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Targeted disruption of the mouse Csrp2 gene encoding the cysteine- and glycine-rich LIM domain protein CRP2 result in subtle alteration of cardiac ultrastructure.

Julia F Sagave | Markus Moser | Elisabeth Ehler | Sabine Weiskirchen | Doris Stoll | Kalle Günther | Reinhard Büttner | Ralf Weiskirchen
BMC developmental biology | 2008

The cysteine and glycine rich protein 2 (CRP2) encoded by the Csrp2 gene is a LIM domain protein expressed in the vascular system, particularly in smooth muscle cells. It exhibits a bimodal subcellular distribution, accumulating at actin-based filaments in the cytosol and in the nucleus. In order to analyze the function of CRP2 in vivo, we disrupted the Csrp2 gene in mice and analysed the resulting phenotype.

Pubmed ID: 18713466

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Associated grants

  • Agency: Medical Research Council, United Kingdom
    Id: G0400153

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