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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
http://www.wormbase.org/db/get?name=WBStrain00050635
Source Database: WormBase (WB)
Affected Genes: WBGene00001333(erm-1)
Genomic Alteration: WBGene00001333(erm-1)
Availability: unknown
Source References: EMPTY
Synonyms: erm-1(mib19[erm-1[T544A]::GFP]) I.
Notes: Homozygous viable. Endogenous erm-1 locus tagged with eGFP and modified to mimic non-phosphorylated ERM-1(T544). Variant affects ERM-1 localization and dynamics. Reduced brood size, increased embryonic and larval lethality. eGFP-tagged ERM-1 is not fully functional: animals have a reduced brood size and incomplete outgrowth of the excretory canal, but show no other developmental or morphological abnormalities. The penetrance of intestinal phenotypes is slightly higher than in untagged T544 mutants, presumably owing to a detrimental influence of the COOH-terminal GFP tag. Reference: Ramalho JJ, et al. Development. 2020 Jul 22;147(14):dev188011. PMID: 32586975|"Made_by: Joao J. Ramalho"
Proper citation: RRID:WB-STRAIN:WBStrain00050635 Copy
http://www.wormbase.org/db/get?name=WBStrain00050634
Source Database: WormBase (WB)
Affected Genes: WBGene00001333(erm-1)
Genomic Alteration: WBGene00001333(erm-1)
Availability: unknown
Source References: EMPTY
Synonyms: erm-1(mib16[erm-1[T544D]::GFP]) I.
Notes: Homozygous viable. Endogenous erm-1 locus tagged with eGFP and modified to mimic ERM-1(T544) phosphorylation. Variant affects ERM-1 localization and dynamics. Reduced brood size, increased embryonic and larval lethality. eGFP-tagged ERM-1 is not fully functional: animals have a reduced brood size and incomplete outgrowth of the excretory canal, but show no other developmental or morphological abnormalities. The penetrance of intestinal phenotypes is slightly higher than in untagged T544 mutants, presumably owing to a detrimental influence of the COOH-terminal GFP tag. Reference: Ramalho JJ, et al. Development. 2020 Jul 22;147(14):dev188011. PMID: 32586975|"Made_by: Joao J. Ramalho"
Proper citation: RRID:WB-STRAIN:WBStrain00050634 Copy
http://www.wormbase.org/db/get?name=WBStrain00050599
Source Database: WormBase (WB)
Availability: unknown
Source References: PMID:35622498
Synonyms: EMPTY
Notes: [2022-03-05T19:12:35.759Z WBPerson712] New Strain: 10.17912/micropub.biology.000534 aakg-1(syb409); aakg-2(syb410); aakg-3(syb411)
Proper citation: RRID:WB-STRAIN:WBStrain00050599 Copy
http://www.wormbase.org/db/get?name=WBStrain00050636
Source Database: WormBase (WB)
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: unknown
Source References: EMPTY
Synonyms: antIs30 II; unc-119(ed9) III.
Notes: antIs30 [attP-f + Cbr-unc-119(+) + glh-2p::phiC31 + rol-6(partial) + myo-2p::GFP + attP-r] II. antIs30 was inserted into ttTi5605 on LG II using MosSCI. GFP expression in pharynx is very weak (as it is single copy) and is easiest to see during the L1-L3 stages. This strain contains a phiC31 docking site and can be used for precise single-copy integration of transgenes via recombination mediated cassette exchange. The docking site contains inverted phiC31-attP sites flanking phiC31 integrase expressed from the glh-2 germline promoter. Integration constructs need to have inverted phiC31-attB sites that flank the intended sequence to be inserted. Reference: Yang FJ, et al. phiC31 integrase for recombination mediated single copy insertion and genome manipulation in C. elegans. Genetics 2021.|"Made_by: Fang-Jung Yang"
Proper citation: RRID:WB-STRAIN:WBStrain00050636 Copy
http://www.wormbase.org/db/get?name=WBStrain00050582
Source Database: WormBase (WB)
Availability: unknown
Source References: PMID:33820857
Synonyms: SNN-1B(S9E).
Notes: Generated from papers flagged positive during the last month for data type afp_otherstrain and contains genotype and gene data.
Proper citation: RRID:WB-STRAIN:WBStrain00050582 Copy
http://www.wormbase.org/db/get?name=WBStrain00050581
Source Database: WormBase (WB)
Availability: unknown
Source References: PMID:33820857
Synonyms: SNN-1B(S9A).
Notes: Generated from papers flagged positive during the last month for data type afp_otherstrain and contains genotype and gene data.
Proper citation: RRID:WB-STRAIN:WBStrain00050581 Copy
http://www.wormbase.org/db/get?name=WBStrain00050587
Source Database: WormBase (WB)
Affected Genes: WBGene00003377(mls-2)
Genomic Alteration: WBGene00003377(mls-2)
Availability: available
Source References: PMID:35224463
Synonyms: mls-2(vy248[mNG::mls-2]) X.
Alternate IDs: CGC_IX4506
Notes: mNG tag inserted into endogenous mls-2 locus after the start codon using CRISPR/Cas9 engineering, producing a translational mNG::MLS-2 reporter protein. Derived by SEC excision of mls-2(vy247[mNG::SEC::mls-2 knock-in]) in parental strain. mNG::MLS-2 is detected in the nucleus of a few cells in embryos, and localizes to the nucleus of a subset of head cells and the M mesoblast in larvae and adults. Reference: Xiong R., et al. (2022). mNG-tagged mls-2 knock-in alleles in C. elegans. microPublication Biology. 10.17912/micropub.biology.000529.|"[2022-02-11T04:54:57.984Z WBPerson12028] New Strain: mls-2(vy248[mNG::mls-2 knock-in]) X; WBPaper00062471"
Proper citation: RRID:WB-STRAIN:WBStrain00050587 Copy
http://www.wormbase.org/db/get?name=WBStrain00050620
Source Database: WormBase (WB)
Affected Genes: WBGene00003020(lin-35)
Genomic Alteration: WBGene00003020(lin-35)
Availability: unknown
Source References: EMPTY
Synonyms: lin-35(kea7[lin-35p::degron::GFP::lin-35]) I; ieSi57 II.
Notes: ieSi57 [eft-3p::TIR1::mRuby::unc-54 3UTR + Cbr-unc-119(+)] II. N-terminal degron::GFP tag was inserted into the endogenous lin-35 locus. A single copy insertion of eft-3p::TIR1::mRuby allows auxin-inducible degradation of LIN-35 in somatic tissues. Generated in N2 background. Reference: Willis AR, et al. Sci Adv. 2021 May 5;7(19):eabf3114. PMID: 33952520 [NOTE: lin-35(kea7) is an N-terminal tag; the methods section of the paper incorrectly describes the tag as a C-terminal insertion.]|"Made_by: Winnie Zhao"
Proper citation: RRID:WB-STRAIN:WBStrain00050620 Copy
http://www.wormbase.org/db/get?name=WBStrain00050586
Source Database: WormBase (WB)
Availability: unknown
Source References: PMID:35224463
Synonyms: EMPTY
Notes: [2022-02-11T04:53:40.239Z WBPerson12028] New Strain: mls-2(vy247[mNG::SEC::mls-2 knock-in]) X; WBPaper00062471
Proper citation: RRID:WB-STRAIN:WBStrain00050586 Copy
http://www.wormbase.org/db/get?name=WBStrain00050584
Source Database: WormBase (WB)
Availability: unknown
Source References: PMID:33392968
Synonyms: EMPTY
Notes: [2022-01-28T00:07:28.948Z WBPerson12028] New Strain: [HSF-1::GFP], WBPaper00060830
Proper citation: RRID:WB-STRAIN:WBStrain00050584 Copy
http://www.wormbase.org/db/get?name=WBStrain00050588
Source Database: WormBase (WB)
Availability: unknown
Source References: PMID:33634121
Synonyms: xnIs3[par-6:PAR-6::GFP + unc-119(+)]; ltIs44 [pie-1p-mCherry::PH (PLC1delta1) + unc-119(+)]V.
Notes: Generated from the supplementary table in Kunz et al 2021 - BV43 - (FT17xOD70) xnIs3[par-6:PAR-6::GFP + unc-119(+)]; ltIs44 [pie-1p-mCherry::PH (PLC1delta1) + unc-119(+)]V.|"Generated via a cross of FT17xOD70"
Proper citation: RRID:WB-STRAIN:WBStrain00050588 Copy
http://www.wormbase.org/db/get?name=WBStrain00050629
Source Database: WormBase (WB)
Availability: unknown
Source References: EMPTY
Synonyms: kyIs262 IV; acEx25.
Notes: kyIs262 [unc-86::myr::GFP + odr-1::RFP] IV. acEx25 [odr-1p::srbc-48::GFP]. Maintain by picking GFP+ to maintain array. Extra-chromosomal GFP expression in AWC neurons. Integrated RFP expression in AWB and AWC. acEx25 rescues srbc-48 mediated defects. Reference: Kaur S & Aballay A. Cell Reports. 2020 May 19; 31(7): 107662. PMID: 32433971|"Made_by: Supender Kaur"
Proper citation: RRID:WB-STRAIN:WBStrain00050629 Copy
http://www.wormbase.org/db/get?name=WBStrain00050572
Source Database: WormBase (WB)
Availability: unknown
Source References: PMID:32905774
Synonyms: (dma-1(yan126[pat-3sp]) I;catp-8(yan22) IV; wyIs592).
Notes: Generated from papers flagged positive during the last month for data type afp_otherstrain and contains genotype and gene data.
Proper citation: RRID:WB-STRAIN:WBStrain00050572 Copy
http://www.wormbase.org/db/get?name=WBStrain00050571
Source Database: WormBase (WB)
Availability: unknown
Source References: PMID:32905774
Synonyms: (dma-1(yan51) I; wyIs592).
Notes: Generated from papers flagged positive during the last month for data type afp_otherstrain and contains genotype and gene data.
Proper citation: RRID:WB-STRAIN:WBStrain00050571 Copy
http://www.wormbase.org/db/get?name=WBStrain00050574
Source Database: WormBase (WB)
Availability: unknown
Source References: PMID:32905774
Synonyms: (crt-1(yan77) V; wyIs592).
Notes: Generated from papers flagged positive during the last month for data type afp_otherstrain and contains genotype and gene data.
Proper citation: RRID:WB-STRAIN:WBStrain00050574 Copy
http://www.wormbase.org/db/get?name=WBStrain00050578
Source Database: WormBase (WB)
Availability: unknown
Source References: PMID:34706230
Synonyms: catp-8(yan22) egl-20(yan129 [pat-3sp]); lqIs58
Notes: Generated from papers flagged positive during the last month for data type afp_otherstrain and contains genotype and gene data.
Proper citation: RRID:WB-STRAIN:WBStrain00050578 Copy
http://www.wormbase.org/db/get?name=WBStrain00050619
Source Database: WormBase (WB)
Affected Genes: WBGene00016216(pals-22)
Genomic Alteration: WBGene00016216(pals-22)
Availability: unknown
Source References: EMPTY
Synonyms: pals-22(kea8[pals-22::GFP::degron]) III.
Notes: C-terminal GFP::degron tag was inserted into the endogenous pals-22 locus. Generated in N2 background. Reference: Willis AR, et al. Sci Adv. 2021 May 5;7(19):eabf3114. PMID: 33952520 [NOTE: pals22(kea8) is a C-terminal tag; the methods section of the paper incorrectly describes the tag as an N-terminal insertion.]|"Made_by: Winnie Zhao"
Proper citation: RRID:WB-STRAIN:WBStrain00050619 Copy
http://www.wormbase.org/db/get?name=WBStrain00050618
Source Database: WormBase (WB)
Affected Genes: WBGene00003020(lin-35)
Genomic Alteration: WBGene00003020(lin-35)
Availability: unknown
Source References: EMPTY
Synonyms: lin-35(kea7[lin-35p::degron::GFP::lin-35]) I.
Notes: Made_by: Winnie Zhao|"N-terminal degron::GFP tag was inserted into the endogenous lin-35 locus. Generated in N2 background. Reference: Willis AR, et al. Sci Adv. 2021 May 5;7(19):eabf3114. PMID: 33952520 [NOTE: lin-35(kea7) is an N-terminal tag; the methods section of the paper incorrectly describes the tag as a C-terminal insertion.]"
Proper citation: RRID:WB-STRAIN:WBStrain00050618 Copy
http://www.wormbase.org/db/get?name=WBStrain00050682
Source Database: WormBase (WB)
Affected Genes: WBGene00012802(set-25)|WBGene00016313(set-4)|WBGene00019883(met-2)
Genomic Alteration: WBGene00012802(set-25), WBGene00016313(set-4), WBGene00019883(met-2)
Availability: unknown
Source References: EMPTY
Synonyms: gwSi17 set-4(n4600) II; met-2(n4256) set-25(n5021) III; gwIs4 X.
Notes: gwSi17 [cec4p::cec4::WmCherry::cec4 3'UTR] II. gwIs4 [baf-1p::GFP-lacI::let-858 3UTR + myo-3p::RFP] X. Worms are slow growing with reduced brood size and become sterile at elevated temperatures. Expresses GFP-LacI throughout development from early embryogenesis, forming a large spot at the lacO array. Worms have red muscle (from L1 stage). CEC-4::WmCherry is visible at the nuclear periphery in embryos and L1 stage animals. Reference: Cabianca DS, et al. Nature 2019 May;569(7758):734-739. PMID: 31118512
Proper citation: RRID:WB-STRAIN:WBStrain00050682 Copy
http://www.wormbase.org/db/get?name=WBStrain00050680
Source Database: WormBase (WB)
Affected Genes: WBGene00012802(set-25)|WBGene00019883(met-2)
Genomic Alteration: WBGene00012802(set-25), WBGene00019883(met-2)
Availability: unknown
Source References: EMPTY
Synonyms: met-2(n4256) set-25(n5021) III.
Notes: Made_by: BenjaminD. Towbin|"Worms are slow growing with reduced brood size and become sterile at elevated temperatures. Mutants co-segregate with ~ 20cM distance. Reference: Towbin BD, et al. Cell. 2012 Aug 31;150(5):934-47. PMID: 22939621"
Proper citation: RRID:WB-STRAIN:WBStrain00050680 Copy
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