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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=19165362
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Alternate IDs: 19165362
Notes: CRISPR/Cas9 system was used to introduce a mutation in the Krtcap3 gene of WKY/NCrl rat embryos. The resulting mutation is a net 2-bp deletion in the exon 2 of the targeted gene, which led to a frameshift mutation and early termination of the KRTCAP3 protein. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_19165362 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=639699398
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Alternate IDs: 639699398
Notes: Cas9 protein and sgRNA targeting the sequence CCTTTTTGCAGAGCACGAAA within exon 2 of Adcy3 were injected into embryos of the WKY/NCrl strain. A 1-bp deletion resulted (rn7: chr6:27,126,062).The homozygous mutant was lethal shortly after birth, so the heterozygous +/- (RGD:19165366) was used for breeding and study. Contact Dr. Solberg-Woods at Wake Forest University School of Medicine, Email: [email protected]
Proper citation: RRID:RGD_639699398 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=329849114
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Alternate IDs: 329849114
Notes: The CRISPR/SpCas9 system was used to introduce a 10-bp deletion (rn6: chr3:153,453,801-153,453,810) in exon 3 of the Ghrh gene in Crl:SD Sprague Dawley embryos.
Proper citation: RRID:RGD_329849114 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=632518357
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Live Animals (as of 2026-02-06)
References:
Synonyms:
Alternate IDs: 632518357
Notes: The endonuclease mediated knock in of the transgenic cassette, CAG-LSL-tdTomato in mouse (ROSA)26Sor, was created in Crl:CD (SD) rats. Cyagen
Proper citation: RRID:RGD_632518357 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=629006637
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Alternate IDs: 629006637
Notes: ANTXR2 knock-out rats were generated using CRISPR/Cas9-mediated genome editing. Specifically, a 67 base pairs deletion in exon 1 of ANTXR2 was induced by 2 guide RNAs targeting sequences within exon 1. The guide RNA targeting vectors and Cas9 were co-injected into the fertilized Sprague Dawley eggs to generate ANTXR2 knock-out rats. The pups were genotyped by PCR and confirmed by sequencing (forward primer: 5′-TTGGGTGGCTCTGAGCTTGGA-3′, reverse primer: 5′-AGGGGTCTAGGGGAGTGTGATAAAGA-3′).
Proper citation: RRID:RGD_629006637 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=25394534
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Alternate IDs: 25394534
Notes: LE-ROSA26em1(CAG-tdTomato)1Sage (RGDID: 12905037) was backcrossed to SS/JrHsdMcwi for more than 8 generations. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_25394534 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=152998996
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2022-07-15)
References:
Synonyms:
Alternate IDs: 152998996
Notes: This model was generated at the Medical College of Wisconsin by CRISPR/Cas9 mutagenesis in Crl:SD strain and harbors a 16-bp deletion in exon 3 of Adh5. rn6.0:chr2:226,979,096-226,979,111. contact MCW Rat Distribution at [email protected]
Proper citation: RRID:RGD_152998996 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=152998993
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2022-07-15)
References:
Synonyms:
Alternate IDs: 152998993
Notes: This model was produced at the Medical College of Wisconsin using CRISPR/Cas9 in the Crl:SD strain. The resulting mutation is a 1-bp insertion in the third exon of the Ager gene. rn6.0:chr20:4,150,403-4,150,403 ins T contact MCW Rat Distribution at [email protected]
Proper citation: RRID:RGD_152998993 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=632645231
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Alternate IDs: 632645231
Notes: This is a heterozygous Galt mutant rat carries one copy of CRISPR/Cas9 system induced 2-base pair insertion mutation into exon 6 in the rat Galt gene of Crl:SD embryos.
Proper citation: RRID:RGD_632645231 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=625777899
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Alternate IDs: 625777899
Notes: To produce Ugt2 cluster (∼762-kb) KO rats, two gRNAs with target sites upstream of Ugt2a1 and the coding region of Ugt2b31-like were injected into rat fertilized eggs.
A knockout strain with Ugt2 cluster mutation carried concatenation of the genomic sequence upstream of Ugt2a1, a 102-bp insertion, and the Ugt2b31-like region.
The F2 homozygous rats showed decreased gemfibrozil glucuronidation activity in the liver.
The result suggested the functional deletion of rat Ugt2 genes in the Ugt2-KO rats.
Proper citation: RRID:RGD_625777899 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=626170603
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Live Animals (as of 2025-09-02)
References:
Synonyms:
Alternate IDs: 626170603
Notes: In collaboration with Horizon Discovery, CRISPR/Cas9 technology was used in Long Evans (LE) embryos to introduce a 10bp deletion in exon 8 of the Cdkl5 gene (Ensembl coordinates X:35,674,763–35,674,772, in the Rnor_6.0 genome assembly) which results in the introduction of an early stop codon in constitutive exon 9, leading to lack of CDKL5 protein expression. Simons Initiative for the Developing Brain (SIDB), Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh EH8 9XD, UK. Contact SIDB Scientific Officer for enquiries on rat distribution ([email protected]).
Proper citation: RRID:RGD_626170603 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=617154644
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Alternate IDs: 617154644
Notes: The CRISPR/Cas9 genetic editing approach was used to generate .a homozygous Long-Evans rat model of human SCA34. The human Cas9 D10A (hCas9-D10A) nickase was used to knock-in the c.736T>G mutation by targeting exon 6 of the rat Elovl4 (Ensembl: ENSRNOG00000009773) located on rat chromosome 8. The hCas9 mRNA, sgRNA(CCTTCCCCAAGTGGATGCAC), and single-strand oligonucleotide donor (ssODN: TTCCATGTGACCATTGGGCACACAGCACTGTCTCTCTACACCGACTGCCCCTTCCCCAAGGGGATGCACTGGGCTCTGATCGCCTATGCCATCAGCTTCATCTTCCTCTTCCTCAACTTCTAC) were co-injected into Long-Evans rat zygotes at the laboratories of Cyagen Bioscience Inc.The heterozygous F0 rats carrying c.736T>G, p.W246G, mutation were bred with with WT Long-Evans rats over several generations to breed out any potential off-target effects and to establish the heterozygous SCA34 Long-Evans rat model. Successfully generation of homozygous SCA34 rats (MUT) by breeding heterozygous rats from the different F0 lines.
Proper citation: RRID:RGD_617154644 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=626168271
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Embryo; Cryorecovery (as of 2025-08-29)
References:
Synonyms:
Alternate IDs: 626168271
Notes: Sprague Dawley rat. Tandem duplication of the genetic interval between Sult1a1 and Spn genes using CRISPR/Cas9 engineering. We targeted the genetic interval borders from one allele and the CRISPR/Cas9 system allowed us to cut and transpose those sequences to the same locus on the second allele. Heterozygous animals are Overweight and hypoactivity. European Mouse Mutant Archive(EMMA)
Proper citation: RRID:RGD_626168271 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=617154642
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Alternate IDs: 617154642
Notes: The CRISPR/Cas9 genetic editing approach was used to generate .a heterozygous Long-Evans rat model of human SCA34. The human Cas9 D10A (hCas9-D10A) nickase was used to knock-in the c.736T>G mutation by targeting exon 6 of the rat Elovl4 (Ensembl: ENSRNOG00000009773) located on rat chromosome 8. The hCas9 mRNA, sgRNA(CCTTCCCCAAGTGGATGCAC), and single-strand oligonucleotide donor (ssODN: TTCCATGTGACCATTGGGCACACAGCACTGTCTCTCTACACCGACTGCCCCTTCCCCAAGGGGATGCACTGGGCTCTGATCGCCTATGCCATCAGCTTCATCTTCCTCTTCCTCAACTTCTAC) were co-injected into Long-Evans rat zygotes at the laboratories of Cyagen Bioscience Inc.The heterozygous F0 rats carrying c.736T>G, p.W246G, mutation were bred with with WT Long-Evans rats over several generations to breed out any potential off-target effects and to establish the heterozygous SCA34 Long-Evans rat model. Successfully generation of homozygous SCA34 rats (MUT) by breeding heterozygous rats from the different F0 lines.
Proper citation: RRID:RGD_617154642 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=156431061
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2026-01-15)
References:
Synonyms:
Alternate IDs: 156431061
Notes: The CRISPR/Cas9 system was used to introduce a T insertion in exon 1 of C17h6orf52 gene causing a frameshift and predicated early truncation of the translated protein in an embryo from LH/MavRrrcAek (RGD:10755352) through electroporation. Currently live colony with Dr. Anne Kwitek at the Medical College of Wisconsin. Being cryopreserved and the live colony will not be available.
Proper citation: RRID:RGD_156431061 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=626168261
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Live Animals (as of 2025-08-29)
References:
Synonyms:
Alternate IDs: 626168261
Notes: Crispr/Cas9 genome editing of the Peg3 gene The strain is deposit at RRRC - University of Missouri
Proper citation: RRID:RGD_626168261 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13506177
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Live Animals (as of 2018-01-31)
References:
Synonyms:
Alternate IDs: 13506177
Notes: CRISPR/SpCas9 targeting was used to introduce an 11-bp putative frame-shift deletion in exon 3. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_13506177 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=626170595
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Live Animals (as of 2025-09-02)
References:
Synonyms:
Alternate IDs: 626170595
Notes: This allele has a deletion of the C2/GAP domain of Syngap1 and was generated by Sigma Advanced Genetic Engineering (SAGE) Labs (St. Louis, MO, US). Zinc-finger nucleases (ZFNs) designed to target Syngap1 exons 8–12 were microinjected into the pronucleus of fertilized, single-cell Long Evans (LE) embryos. A 3,584-bp selective deletion and 3-bp insertion were confirmed by sequencing, which resulted in a mutant protein that was 377 amino acids smaller than endogenous SYNGAP1. Simons Initiative for the Developing Brain (SIDB), Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh EH8 9XD, UK. Contact SIDB Scientific Officer for enquiries on rat distribution ([email protected]).
Proper citation: RRID:RGD_626170595 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=632518398
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Live Animals (as of 2026-02-12)
References:
Synonyms:
Alternate IDs: 632518398
Notes: The CRISPR/Cas9 system was multiplexed to introduce a double strand brake at exon 3 and 14 to promote the removal of majority of the MPO gene in rat embryos. Animal Modeling Core at the University of Missouri. Availability Contact Email: [email protected]
Proper citation: RRID:RGD_632518398 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=153297754
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Live Animals (as of 2022-07-21)
References:
Synonyms:
Alternate IDs: 153297754
Notes: This strain was produced at the Medical College of Wisconsin using CRISPR Cas9 mutagenesis in the Crl:SD strain. A CRISPR SpCas9/sgRNA targeting the GTCCTTTGCAGTCCCTGCCG sequence within exon 15 of Gsap and a 5-bp indel (rn72: chr4:13,849,488-13,849,492) was identified.
Proper citation: RRID:RGD_153297754 Copy
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