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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12904912
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Embryo (as of 2017-05-24)
References:
Synonyms:
Alternate IDs: 12904912
Notes: This ZFN model possesses a 151 bp deletion spanning exon 1/intron 1 junction of Leptin gene. Homozygous knockout rats display loss of Leptin protein via Western blot. Homozygous knockout rats demonstrate significant weight gain compared to wild type littermates. Homozygous knockout rats show significantly elevated serum cholesterol levels Inotiv
Proper citation: RRID:RGD_12904912 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13506832
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2021-11-03)
References:
Synonyms:
Alternate IDs: 13506832
Notes: CRISPR/Cas9 system was used to introduce a mutation in the P2rx7 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is an 10-bp putative frame-shift deletion in exon 2 Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_13506832 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13506831
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2018-02-21)
References:
Synonyms:
Alternate IDs: 13506831
Notes: CRISPR/Cas9 system was used to introduce a mutation in the P2rx7 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is an 11-bp putative frame-shift deletion in exon 2 Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_13506831 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12904891
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Live Animals (as of 2017-05-24)
References:
Synonyms:
Alternate IDs: 12904891
Notes: This ZFN model carries the knockout of the rat Slc22a2. Horizon Discovery
Proper citation: RRID:RGD_12904891 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12904892
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Embryo (as of 2017-05-24)
References:
Synonyms:
Alternate IDs: 12904892
Notes: This ZFN model carries the knockout of the rat Slc22a6. Horizon Discovery
Proper citation: RRID:RGD_12904892 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12904897
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Extinct (as of 2024-04-16)
References:
Synonyms:
Alternate IDs: 12904897
Notes: This ZFN model carries the monoallelic 11 base pair deletion in Tp53 gene. Animals exhibit broad tumor spectrum with high degree of tumor malignancy. Horizon Discovery
Proper citation: RRID:RGD_12904897 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13210578
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Alternate IDs: 13210578
Notes: This CRISPR/Cas9 model possesses a 3 bp(ATC) deletion resulting in the deletion of isoleucine at position 14. The Lep mutant rats exhibited similar mutant phenotypes to Lep and Lepr null rats.
Proper citation: RRID:RGD_13210578 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13800845
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2023-06-21)
References:
Synonyms:
Alternate IDs: 13800845
Notes: CRISPR/Cas9 system was used to introduce a 2-bp deletion in exon 1 of rat Mybphl gene in the FHH/EurMcwi embryos. embryos. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_13800845 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13792803
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2023-06-21)
References:
Synonyms:
Alternate IDs: 13792803
Notes: This allele was made by CRISPR/Cas9 system. The resulting mutation is a 10-bp deletion in Exon 2 of the P2rx7 gene.
Proper citation: RRID:RGD_13792803 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13792801
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2018-09-28)
References:
Synonyms:
Alternate IDs: 13792801
Notes: CRISPR/Cas9 system was used to introduce a mutation in the Nlrp3 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 14-bp deletion of exon 1 in the Nlrp3 gene. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_13792801 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12910101
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Alternate IDs: 12910101
Notes: This model possesses a 19-bp deletion in the seventh exon of the ldlr gene by ZFN method.
Proper citation: RRID:RGD_12910101 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12907570
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Alternate IDs: 12907570
Notes: This model contains one 19- bp deletion and one 428-bp deletion within Abcba1 gene. The homozygous knockout rats display total loss of protein via Western blot.
Proper citation: RRID:RGD_12907570 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12907568
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Alternate IDs: 12907568
Notes: This model contains biallelic 19- bp deletion in exon 7 of Abcba1 gene. The homozygous knockout rats display total loss of protein via Western blot.
Proper citation: RRID:RGD_12907568 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13782280
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Alternate IDs: 13782280
Notes: Zinc Finger Nuclease (ZFN) was utilized to knockout rat Kcnj1 function. ZFN constructs targeting the gene were designed and purchased from Sigma Aldrich (St. Louis, MO, USA). The targeting site sequence is CTCAAGTGACCATAGGTTACGgattcaGGTTTGTGAC (lower case represents the ZFN cleavage site). Kcnj1 knockout founders were generated by microinjection of ZFN mRNAs into single-cell SS (from Harlan) rat embryos. The resulting mutation is 209 bp deletion from G225 to G433, leading to frameshift and premature termination of Kcnj1 protein. This strain is the wild type littermate from heterozygous cross.
Proper citation: RRID:RGD_13782280 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12910762
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Alternate IDs: 12910762
Notes: A spontaneous mutant male with a large white spot and coat color dilution was identified in the BN/fMai colony in Yagi Memorial Park (kani-gun, Japan).
Proper citation: RRID:RGD_12910762 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12910519
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Alternate IDs: 12910519
Notes: This strain was produced by injecting TALEN targeting the sequence of rat Lepr into SD embryos. The resulting mutation is a 18-bp insertion.
Proper citation: RRID:RGD_12910519 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12910514
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Alternate IDs: 12910514
Notes: This strain was produced by injecting TALEN targeting the sequence of rat Lepr into SD embryos. The resulting mutation is a 57-bp deletion.
Proper citation: RRID:RGD_12910514 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13781890
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Alternate IDs: 13781890
Notes: Two pairs of CRISPR guide RNAs were designed to cleave together to delete all 9 exons of RNaseT2. The CRISPR guide RNA and Cas9 mRNA mixtures were microinjected into the pronuclei of fertilized embryos of Sprague-Dawley rats and transferred to pseudopregnant female rats. WT, heterozygous and homozygous (KO) rats were born in the expected Mendelian ratio, and homozygous RNaseT2 KO rats were viable and fertile.
Proper citation: RRID:RGD_13781890 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13792808
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2021-11-03)
References:
Synonyms:
Alternate IDs: 13792808
Notes: CRISPR/Cas9 system was used to introduce a mutation in the Ptk2b gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 8-bp deletion in exon 2.
Proper citation: RRID:RGD_13792808 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12910517
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Alternate IDs: 12910517
Notes: This strain was produced by injecting TALEN targeting the sequence of rat Lepr into SD embryos. The resulting mutation is a 1-bp deletion.
Proper citation: RRID:RGD_12910517 Copy
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Data set from Kravitz, Owen and Kretizer's 2012 paper "Optogenetic identification of striatal projection neuron subtypes during in vivo recordings."
