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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12790599
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2021-11-03)
References:
Synonyms:
Alternate IDs: 12790599
Notes: CRISPR/Cas9 system was used to introduce a mutation in the Asic3 gene of WKY/Ncrlrat embryos. The resulting mutation is a 61-bp deletion in the exon 1 of the Asic3 gene. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_12790599 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12790632
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Live Animals; Cryopreserved Sperm (as of 2021-11-03)
References:
Synonyms:
Alternate IDs: 12790632
Notes: This strain was produced by injecting TALENs targeting the sequence of Il2rg gene into the SS/JrHsdMcwi rat embryos. The resulting mutation is a 19-bp deletion in exon 2.
Proper citation: RRID:RGD_12790632 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=11568040
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Live Animals (as of 2017-05-09)
References:
Synonyms:
Alternate IDs: 11568040
Notes: The ZFN mutant rat strain was produced by injecting zinc finger nuclease targeting rat Fmr1 into Sprague Dawley embryos. The resulting mutation was a 122bp deletion of the intron 7/exon8 junction occurred at 18533bp-18654bp. This mutant rat has a knockout of Fmr1. Horizon Discovery
Proper citation: RRID:RGD_11568040 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=11553875
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2021-11-03)
References:
Synonyms:
Alternate IDs: 11553875
Notes: CRISPR/Cas9 system was used to introduce a mutation in the Fmr1 gene of Crl:LE rat embryos. The resulting mutation is a 2-bp deletion in exon 8 of the Fmr1 gene. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_11553875 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=11553873
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Live Animals; Cryopreserved Sperm (as of 2021-11-03)
References:
Synonyms:
Alternate IDs: 11553873
Notes: CRISPR/Cas9 system was used to introduce a mutation in the Fmr1 gene of Crl:LE rat embryos. The resulting mutation is a 2-bp insertion in exon 8 of the Fmr1 gene. Autism Rat Model Resource, Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_11553873 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12790695
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Extinct (as of 2017-02-20)
References:
Synonyms:
Alternate IDs: 12790695
Notes: CRISPR/Cas9 system was used to introduce a mutation in the Pon1 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 8-bp deletion of exon 5 in the Pon1 gene. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_12790695 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12790610
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2021-11-03)
References:
Synonyms:
Alternate IDs: 12790610
Notes: CRISPR/Cas9 system was used to introduce a mutation in the Cd14 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a net 7-bp deletion of the Cd14 gene. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_12790610 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12790692
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2021-11-03)
References:
Synonyms:
Alternate IDs: 12790692
Notes: CRISPR/Cas9 system was used to introduce a mutation in the Pon1 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 7-bp insertion of exon 4 in the Pon1 gene. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_12790692 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=11565826
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown (as of 2016-11-28)
References:
Synonyms:
Alternate IDs: 11565826
Notes: These ZFN mutant rats were produced by injecting zinc finger nuclease targeting rat Ttn into F344 embryos. The zinc-finger nuclease mediated genome editing system created a 12-bp deletion and a 2-bp insertion (TA) at 228,608-228,619 (Rnor_5.0) to introduce a stop codon in exon 303, corresponding to exon 327 in the human sequence. Duke-National University of Singapore, Singapore
Proper citation: RRID:RGD_11565826 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=11553902
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2021-11-03)
References:
Synonyms:
Alternate IDs: 11553902
Notes: CRISPR/Cas9 system was used to introduce a mutation in the Trpc6 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 18-bp deletion in Exon 2 of the Trpc6 gene. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_11553902 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=11553860
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2017-01-26)
References:
Synonyms:
Alternate IDs: 11553860
Notes: ZFN system was used to introduce a mutation in the Scn5a gene of DA/MolTac rat embryos. The resulting mutation is a 110-bp deletion in Exon 4 of the Scn5a gene. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_11553860 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=11564349
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2016-11-16)
References:
Synonyms:
Alternate IDs: 11564349
Notes: The TALEN genome editing system was used to generate this mutant rat strain. The TALEN system caused a 16-bp deletion in the exon4 of Aspa gene, as a result created a premature stop codon in the gene. Decreased expression levels of Aspa gene and ASPA protein was observed. Histopatologically, this strain shows vacuole formation in the brain and spinal cord. National BioResource Project for the Rat in Japan
Proper citation: RRID:RGD_11564349 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12790627
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2021-11-03)
References:
Synonyms:
Alternate IDs: 12790627
Notes: CRISPR/Cas9 system was used to introduce a mutation in the Igh-6 gene of LEW/NCrl rat embryos. The resulting mutation is a 8-bp deletion in the exon 2 of the Igh-6 gene. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_12790627 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=11568703
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Embryo (as of 2016-12-13)
References:
Synonyms:
Alternate IDs: 11568703
Notes: The ZFN mutant rat strain was produced by injecting zinc finger nuclease targeting rat Nlgn3 into Sprague Dawley embryos. This model contains 4-bp deletion at 460,649 to 460,652 bp in genomic sequence resulting in an early stop codon in exon 6. Horizon Discovery
Proper citation: RRID:RGD_11568703 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12790623
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Live Animals; Cryopreserved Sperm (as of 2021-11-03)
References:
Synonyms:
Alternate IDs: 12790623
Notes: CRISPR/Cas9 system was used to introduce a mutation in the Cybb gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 35-bp deletion in the exon 3 of the Cybb gene. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_12790623 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=11564346
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2016-11-16)
References:
Synonyms:
Alternate IDs: 11564346
Notes: The TALEN genome editing system was used to generate this mutant rat strain. The TALEN system caused a 14-bp deletion in the exon4 of Aspa gene, as a result created a premature stop codon in the gene. Decreased expression levels of Aspa gene and ASPA protein was observed. Histopatologically, this strain shows vacuole formation in the brain and spinal cord. National BioResource Project for the Rat in Japan
Proper citation: RRID:RGD_11564346 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12879400
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Live Animals; Cryopreserved Sperm (as of 2017-04-18)
References:
Synonyms:
Alternate IDs: 12879400
Notes: This rat strain was established by ZFN method targeting rat Atm gene (resulting in a 8-bp deletion of exon13). Background strain: F344/Stm. National BioResource Project for the Rat in Japan
Proper citation: RRID:RGD_12879400 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12738365
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2021-11-03)
References:
Synonyms:
Alternate IDs: 12738365
Notes: This strain was produced by injecting TALENs targeting the sequence into Crl:SD rat embryos. The resulting mutation is a 10-bp frameshift deletion,Atgttgagat, in exon 2.
Proper citation: RRID:RGD_12738365 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12790950
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2017-02-22)
References:
Synonyms:
Alternate IDs: 12790950
Notes: This strain was produced by injecting ZFNs targeting the sequence of Sorcs2 into SS/JrHsdMcwi rat embryos. The resulting mutation is a 1-bp frameshift deletion in exon 15.
Proper citation: RRID:RGD_12790950 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=11553892
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2018-10-10)
References:
Synonyms:
Alternate IDs: 11553892
Notes: CRISPR/Cas9 system was used to introduce a mutation in the Trpc3 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 1-bp insertion in Exon 2 of the Trpc3 gene. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_11553892 Copy
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Data set from Kravitz, Owen and Kretizer's 2012 paper "Optogenetic identification of striatal projection neuron subtypes during in vivo recordings."
