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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.
http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?iter
ITER is a toxicology data file on the National Library of Medicine''s (NLM) Toxicology Data Network. It contains data in support of human health risk assessments. It is compiled by Toxicology Excellence for Risk Assessment (TERA) and contains over 600 chemical records with key data from the Agency for Toxic Substances & Disease Registry (ATSDR), Health Canada, National Institute of Public Health & the Environment (RIVM) - The Netherlands, U.S. Environmental Protection Agency (EPA), and independent parties whose risk values have undergone peer review. ITER provides a comparison of international risk assessment information in a side-by-side format and explains differences in risk values derived by different organizations. ITER data, focusing on hazard identification and dose-response assessment, is extracted from each agencys assessment and contains links to the source documentation. Among the key data provided in ITER are ATSDRs minimal risk levels; Health Canadas tolerable intakes/concentrations and tumorigenic doses/concentrations; EPAs carcinogen classifications, unit risks, slope factors, oral reference doses, and inhalation reference concentrations; RIVMs maximum permissible risk levels; NSF International''s reference doses and carcinogen risk levels, IARC''s cancer classifications, and noncancer and/or cancer risk values (that have undergone peer review) derived by independent parties. Users can search by chemical or other name, chemical name fragment, or Chemical Abstracts Service Registry Number(RN), and/or subject terms. Search results can easily be viewed, printed or downloaded. Search results are displayed in relevancy ranked order. Users may select to display exact term matches, complete records, or any combination of data from the following broad groupings: -Noncancer Oral -Cancer Oral -Noncancer Inhalation -Cancer Inhalation
Proper citation: International Toxicity Estimates for Risk (RRID:SCR_008196) Copy
JenPep is a database of quantitative binding data for immunological protein-peptide interactions. It is a system which allows speedy access to this binding data through simple on-line interfaces and effective search mechanisms.
Proper citation: JenPep (RRID:SCR_008191) Copy
http://www.thearkdb.org/arkdb/
This website contains the mapping sequence of poultry. The ArkDB database system aims to provide a comprehensive public repository for genome mapping data from farmed and other animal species. In doing so, it aims to provide a route in to genomic and other sequence from the initial viewpoint of linkage mapping, RH mapping, physical mapping or - possibly more importantly - QTL mapping data. It's supported, in part, by the USDA-CSREES National Animal Genome Research Program in order to serve the poultry genome mapping community. This system represents a complete rewrite of the original version with the code migrated to java and the underlying database targeted at postgres (although any standards-compliant database engine should suffice). The initial release records details of maps and the markers that they contain. There are alternative entry points that target either a chromosome or a specific mapping analysis as the starting point. Limited relationships between markers are recorded and displayed. As with the previous version, all maps are drawn using data extracted from the database on the fly.
Proper citation: ChickBase (RRID:SCR_008147) Copy
http://microbialgenomics.energy.gov/index.shtml
Through its Microbial Genome Program (MGP) and its Genomics:GTL (GTL) program, DOEs Office of Biological and Environmental Research (BER) has sequenced more than 485 microbial genomes and 30 microbial communities having specialized biological capabilities. Identifying these genes will help investigators discern how gene activities in whole living systems are orchestrated to solve myriad life challenges. The MGP was begun in 1994 as a spinoff from the Human Genome Program. The goal of the program was to sequence the genomes of a number of nonpathogenic microbes that would be useful in solving DOE''s mission challenges in environmental-waste cleanup, energy production, carbon cycling, and biotechnology. Past projects include microbial genome program, microbial cell project, and the Laboratory Science Program at the DOE Joint Genome Institute. The two ongoing projects are Genomics: GTL program and Community Sequencing Program at the DOE Joint Genome Institute. Sponsors: Site sponsored by the U.S. Department of Energy Office of Science, Office of Biological and Environmental Research, THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.
Proper citation: Microbial Genomics Program (RRID:SCR_008140) Copy
http://www.biology.emory.edu/research/Prinz/database/database.html
This page describes the contents of a database of 1.7 million model neurons. This database is available for interested researchers after contacting the creators, but is not web accessible. The construction and analysis of the database are described in detail in Prinz AA, Billimoria CP, Marder E (2003). Alternative to hand-tuning conductance-based models: construction and analysis of databases of model neurons. J Neurophysiol 90: 3998-4015. Because of its size (over 6 GB even in the zipped version), it is not practicable to download the database over the internet. Instead, we have made multiple copies of the database on sets of two DVDs each. We are happy to send a set of DVDs to anybody who is interested upon e-mail request to Astrid Prinz.
Proper citation: Crustacean stomatogastric model neuron database (RRID:SCR_008260) Copy
http://www.ebi.ac.uk/ipd/mhc/bola/
This website is intended to be the definitive source of information on the bovine major histocompatibility complex - its genes, proteins and polymorphism. Its purpose is to collate data on the Bovine Leucocyte Antigens (BoLA) and provide a forum for the analysis and nomenclature of polymorphisms in the genes and proteins of the bovine MHC. The BoLA nomenclature committee is a standing committee of the International Society for Animal Genetics. Its purpose is to collate data on the Bovine Leucocyte Antigens (BoLA) and provide a forum for the analysis and nomenclature of polymorphisms in the genes and proteins of the bovine MHC. The information gathered here is based on the BoLA workshop reports, which are published in Animal Genetics and the European Journal of Immunogenetics. The workshop report data are reproduced with the permission of the publishers Blackwell Science, and other text on the site is used with the permission of CRC Press.
Proper citation: BoLA Nomenclature: International Society for Animal Genetics (RRID:SCR_008142) Copy
WHOSIS, the WHO Statistical Information System, is an interactive database bringing together core health statistics for the 193 WHO Member States. It comprises more than 100 indicators, which can be accessed by way of a quick search, by major categories, or through user-defined tables. The data can be further filtered, tabulated, charted and downloaded. The data are also published annually in the World Health Statistics Report released in May. The WHO Statistical Information System is the guide to health and health-related epidemiological and statistical information available from the World Health Organization. Most WHO technical programs make statistical information available, and they will be linked from here. Sponsors: WHOSIS is supported by the World Health Organization. Note: The WHO Statistical Information System (WHOSIS) has been incorporated into the Global Health Observatory (GHO) to provide you with more data, more tools, more analysis and more reports.
Proper citation: World Health Organization Statistical Information System (RRID:SCR_008250) Copy
http://etblast.vbi.vt.edu/argh/index.shtml
ARGH is an automated, accurate and scalable method by which acronym-definition pairs can be identified within text. Its primary advantage is in enabling information processing methods to resolve author-defined acronyms, however it also allows an automated creation of a reference work on acronym definitions.
ARGH has several advantages over manual or semi-automated methods, besides time and effort saved, such as enabling identification of relative frequencies for alternate acronyms and definitions as well as spelling, phrasing and hyphenation variants for a unique acronym-definition pair. It also aids users in identifying acronym/definition variants present in the literature that may not necessarily be in biomedical databases.
ARGH functions by a set of heuristics to accurately locate and identify the boundaries of acronym-definition pairs was developed and refined in terms of precision and recall on subsets of MEDLINE records. These training sets were gradually increased in size and heuristics re-evaluated to ensure scalability.
ARGH can be tested on over 12 million MEDLINE records, and it can identify more than 174,000 unique acronyms and their 737,000 associated definitions. Currently, it is the world''s largest and most comprehensive catalog of biomedical acronyms and abbreviations, containing approximately 257,000 out of an estimated 277,000 unique acronyms within MEDLINE.
Sponsors: ARGH is a service of UT Southwestern eTBLAST team.
Proper citation: ARGH: Biomedical Acronym Resolver (RRID:SCR_008131) Copy
http://www.pd-doc.org/Databases/LinkedDatabases/PSGDatabases/QE2Study/tabid/160/Default.aspx
THIS RESOURCE IS NO LONGER IN SERVICE, documented on July 17, 2013. This site has a dataset from the QE2 Study: Effects of CoEnzyme Q10 in Early Parkinson's Disease, was an NINDS funded pilot study of 80 subjects with early untreated Parkinson's disease (PD). The PI was Clifford Shults, MD at UCSD. It was a randomized, double-blind, parallel group comparison of three doses of coenzyme Q10 (CoQ10) (300, 600 and 1200 mg/day) versus placebo in patients and do not yet require treatment with levodopa. The QE2 Study: Effects of CoEnzyme Q10 in Early Parkinson's Disease, was an NINDS funded pilot study of 80 subjects with early untreated Parkinson's disease (PD). The PI was Clifford Shults, MD at UCSD. It was a randomized, double-blind, parallel group comparison of three doses of coenzyme Q10 (300, 600 and 1200 mg/day) versus placebo in patients and do not yet require treatment with levodopa or any other antiparkinsonian medication. Enrollment period May 1999 Feb. 2000; study participation ended June 2001.
Proper citation: Effects of CoEnzyme Q10 in Early Parkinson's Disease (RRID:SCR_008094) Copy
The MIPS mammalian protein-protein interaction database (MPPI) is a new resource of high-quality experimental protein interaction data in mammals. The content is based on published experimental evidence that has been processed by human expert curators. It is a collection of manually curated high-quality PPI data collected from the scientific literature by expert curators. We took great care to include only data from individually performed experiments since they usually provide the most reliable evidence for physical interactions. To suit different users needs we provide a variety of interfaces to search the database: -Expert interface Simple but powerful boolean query language. -PPI search form Easy to use PPI search -Protein search Just find proteins of interest in the database Sponsors: This work is funded by a grant from the German Federal Ministry of Education and Research.
Proper citation: MIPS Mammalian Protein-Protein Interaction Database (RRID:SCR_008207) Copy
http://mips.helmholtz-muenchen.de/genre/proj/mpcdb/
A database of manually annotated mammalian protein complexes. To obtain a high-quality dataset, information was extracted from individual experiments described in the scientific literature. Data from high-throughput experiments was not included.
Proper citation: Mammalian Protein Complex Data Base (RRID:SCR_008209) Copy
http://pbs.jhu.edu/research/Yantis/publications/ClassicPapers
This website contains a list of classic articles in visual perception. They are listed alphabetically by the last name if the article''s author.
Proper citation: Classic Articles in Visual Perception (RRID:SCR_008325) Copy
THIS RESOURCE IS NO LONGER IN SERVICE. Documented on November 22, 2023. A database containing genomic/biological information on anopheline mosquitoes, with an emphasis on Anopheles gambiae, the world''''s most important malaria vector. AnoBase is an integrated, relational database of basic biological and genetic data on anopheline species, with a particular emphasis on Anopheles gambiae. It has been designed as an information source and research support tool for the broad vector biology community. Although AnoBase is not a primary genomic database that develops and provides tools to access the genome of the malaria mosquito, it nevertheless contains several sections that offer data of genomic interest such as in situ hybridization images, an integrated gene tool and direct online access to AnoXcel, the proteomic database of An. gambiae. Moreover, AnoBase also contains information on non-gambiae mosquito species and a novel section on studies related to insecticide resistance.
Proper citation: AnoBase: An Anopheles database (RRID:SCR_008166) Copy
http://www.molgen.ua.ac.be/ADMutations/default.cfm?MT=1&ML=0&Page=ADMDB
A locus-specific database aimed at collecting known mutations and non-pathogenic coding variations in the genes related to Alzheimer disease (AD) and frontotemporal dementia (FTD), following the guidelines of the Human Genome Variation Society. Mutations can be retrieved based on the gene, phenotype and publication. The database contains mutations reported in the literature and at scientific meetings, and unpublished mutations directly submitted to the database. To date, AD&FTDMDB contains mutations in the genes encoding the Amyloid Beta Precursor Protein (APP), Presenilin 1 (PSEN1), Presenilin 2 (PSEN2), Chromatin Modifying Protein 2B (CHMP2B), fusion (involved in t(12;16) in malignant liposarcoma) (FUS), Granulin (GRN), Microtubule Associated Protein Tau (MAPT), TAR DNA binding protein (TARDBP) and Valosin-containing Protein (VCP) and holds 415 different mutations observed in 1027 patients or families. As of March 2013, the latest publications referenced were from 2008, indicating that this resource may not be up to date.
Proper citation: Alzheimer Disease and Frontotemporal Dementia Mutation Database (RRID:SCR_008286) Copy
http://locustdb.genomics.org.cn/
The migratory locust (Locusta migratoria) is an orthopteran pest and a representative member of hemimetabolous insects. Its transcriptomic data provide invaluable information for molecular entomology study of the insect and pave a way for comparative studies of other medically, agronomically, and ecologically relevant insects. This first transcriptomic database of the locust (LocustDB) has been developed, building necessary infrastructures to integrate, organize, and retrieve data that are either currently available or to be acquired in the future. It currently hosts 45,474 high quality EST sequences from the locust, which were assembled into 12,161 unigenes. This database contains original sequence data, including homologous/orthologous sequences, functional annotations, pathway analysis, and codon usage, based on conserved orthologous groups (COG), gene ontology (GO), protein domain (InterPro), and functional pathways (KEGG). It also provides information from comparative analysis based on data from the migratory locust and five other invertebrate species, such as the silkworm, the honeybee, the fruitfly, the mosquito and the nematode. LocustDB also provides information from comparative analysis based on data from the migratory locust and five other invertebrate species, such as the silkworm, the honeybee, the fruitfly, the mosquito and the nematode. It starts with the first transcriptome information for an orthopteran and hemimetabolous insect and will be extended to provide a framework for incorporation of in-coming genomic data of relevant insect groups and a workbench for cross-species comparative studies.
Proper citation: Migratory Locust EST Database (RRID:SCR_008201) Copy
http://andromeda.gsf.de/litminer
THIS RESOURCE IS NO LONGER IN SERVICE, documented August 23, 2016. The LitMiner software is a literature data-mining tool that facilitates the identification of major gene regulation key players related to a user-defined field of interest in PubMed abstracts. The prediction of gene-regulatory relationships is based on co-occurrence analysis of key terms within the abstracts. LitMiner predicts relationships between key terms from the biomedical domain in four categories (genes, chemical compounds, diseases and tissues). The usefulness of the LitMiner system has been demonstrated recently in a study that reconstructed disease-related regulatory networks by promoter modeling that was initiated by a LitMiner generated primary gene list. To overcome the limitations and to verify and improve the data, we developed WikiGene, a Wiki-based curation tool that allows revision of the data by expert users over the Internet. It is based on the annotation of key terms in article abstracts followed by statistical co-citation analysis of annotated key terms in order to predict relationships. Key terms belonging to four different categories are used for the annotation process: -Genes: Names of genes and gene products. Gene name recognition is based on Ensembl . Synonyms and aliases are resolved. -Chemical Compounds: Names of chemical compounds and their respective aliases. -Diseases and Phenotypes: Names of diseases and phenotypes -Tissues and Organs: Names of tissues and organs LitMiner uses a database of disease and phenotype terms for literature annotation. Currently, there are 2225 diseases or phenotypes, 801 tissues and organs, and 10477 compounds in the database.
Proper citation: LitMiner (RRID:SCR_008200) Copy
http://www.compneuro.org/CDROM/catacomb/index.html
Catacomb consists of a set of frameworks for various types of models in neuroscience, user interfaces to facilitate building models within these frameworks, and numerical algorithms to compute their behavior. The available frameworks include reaction kinetics, reaction diffusion systems, kinetic scheme models of ion channels, small neuron models and integrate and fire networks. It is a library of models (data structures and algorithms) covering a range of problems in neuroscience together with a versatile graphical user interface for constructing and running specific instances of the models. Some features of Catacomb include: * Class models. There is a growing set of classes containing data structures and calculation methods for various problem domains in neuroscience - reaction schemes, stochastic channel models, integrate-and-fire networks, cell geometry et al. * Dynamic interface builder. Using Java''s reflection capabilities, individual user interfaces are constructed for each class model allowing new instances to be created and displaying the results of any calculation methods they may contain. * Parameter watching. Using Java threads, the calculations are rerun and results displayed whenever parameters upon which they depend are changed. * Session recording. Operations can be recorded and played back for illustrating how to use Catacomb or for preconfigured demonstrations of model behavior. * Compatible with JPython. Catacomb does not include its own interpreter except in the minimal sense required to parse its own saved files. But its objects and methods are accessible to JPython which can be used for command line access or scripting. * Applet building. The contents of windows in the display can be extracted and packaged together in a single panel for loading as an applet. The model is saved as a java source file which, once compiled, can be packaged with the original Catacomb archive for loading from a Web page. See the AppletConfigEditor.
Proper citation: Components And Tools for Accessible COmputer Modeling in (neuro)Biology (RRID:SCR_008321) Copy
http://www.ebi.ac.uk/asd/altsplice/index.html
AltSplice is a computer generated high quality data set of human transcript-confirmed splice patterns, alternative splice events, and the associated annotations. This data is being integrated with other data that is generated by other members of the ASD consortium. The ASD project will provide the following in its three year duration: -human curated database of alternative spliced genes and their properties -a computer generated database of alternatively spliced genes and their properties -the integration of the above and newly found knowledge in a user-friendly interface and research workbench for both bioinformaticists and biologists -DNA chips that are based on the data in the above databases -the DNA chips will be used to test against predisposition for and diagnoses of human diseases ASD aims to analyse this mechanism on a genome-wide scale by creating a database that contains all alternatively spliced exons from human, and other model species. Disease causing mutations seem to induce aberrations in the process of splicing and its regulation. The ASD consortium will develop a DNA microarray (chip) that contains cDNAs of all the splicing regulatory proteins and their isoforms, as well as a chip that contains a number of disease relevant genes. We will concentrate on three models of disease (breast cancer, FTDP-17, male infertility) in which a connection between mis-splicing and a pathological state has been observed. Finally, these chips will be developed as demonstrative kits to detect predisposition for and diagnosis of such diseases. Categories: Nucleotide Sequences: Gene Structure, Introns and Exons, & Splice Sites Databases
Proper citation: AltSplice Database of Alternative Spliced Events (RRID:SCR_008162) Copy
http://research.amnh.org/herpetology/amphibia/index.php
The Amphibian Species of the World database has two searching tools, a BROWSE table and a SEARCH table. It provides needed information for research and conservation needs and to help illuminate where geographical data or taxonomic information are woefully inadequate. In addition, all underlined author names, dates, and publications may be clicked through to see other records citing this author, date, or publication. The basic structure of a taxonomic record is (1) Current scientific name, author and year of publication; (2) original name, authorship, citation, and if relevant, location of primary types and type locality (direct quotation if possible). This is followed by a synonymy composed of all new names, their authorship, literature citation, and (if relevant) location of primary types, and type locality as well as all new combinations and the literature source of the synonymy or combination; (3) published English names; (4) known or inferred distribution of the taxon; (5) comments to controversies or relevant taxonomic literature. A synonymy follows the currently recognized name. The synonymy includes synonyms and relevant combinations (in the sense of the International Code of Zoological Nomenclature, 1999) as well as deposition of types, type localities, and the source of the synonymy. Users who are looking for the synonymy to provide unerringly and precisely the names by which a taxon have been mentioned will be disappointed, and will be misled if they approach synonymies this way.
Proper citation: Amphibian Species of the World (RRID:SCR_008164) Copy
http://toxnet.nlm.nih.gov/altbib.html
Bibliography to assist in identifying methods and procedures helpful in supporting the development, testing, application, and validation of alternatives to the use of vertebrates in biomedical research and toxicology testing. This bibliography is produced from MEDLINE database searches, performed and analyzed by subject experts from the Toxicology and Environmental Health Information Program (TEHIP) of the Specialized Information Services Division (SIS) of the National Library of Medicine (NLM). The purpose of these bibliographies on animal alternatives is to provide a survey of the literature in a format which facilitates easy scanning. This bibliography includes citations from published articles, books, book chapters, and technical reports. Citations to items in non-English languages are indicated with brackets around the title. The language is also indicated. Citations with abstracts or annotations relating to the method are organized under subject categories. This publication features citations which deal with methods, tests, assays or procedures which may prove useful in establishing alternatives to the use of intact vertebrates. Citations are selected and compiled through searching various computerized on-line bibliographic databases of the National Library of Medicine, National Institutes of Health. The focus of the bibliography is to assist in identifying methods and procedures helpful in supporting the development, testing, application, and validation of alternatives to the use of vertebrates in biomedical research and toxicology testing. Toxicology Databases
Proper citation: Bibliography on Alternatives to the Use of Live Vertebrates in Biomedical Research and Testing (RRID:SCR_008160) Copy
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