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Cellosaurus is database indexing available cell lines from various collections: American Type Culture Collection (ATCC), Bioresource Collection and Research Center, Taiwan (BCRC), Banco de Células do Rio de Janeiro (BCRJ), CellBank Australia (CBA), Collection of Cell Lines in Veterinary Medicine (CCLV), Cell Lines Service (CLS), Coriell, Drosophila Genomics Resource Center (DGRC), Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH (DSMZ), European Bank for induced pluripotent Stem Cells (EBiSC), European Collection of Authenticated Cell Cultures (ECACC), Interlab Cell Line Collection (ICLC), Institute for Fermentation Osaka (IFO), Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna (IZSLER) biobank, Japanese Collection of Research Bioresources (JCRB) Cell Bank, Kunming Cell Bank of Type Culture Collection (KCB), Korean Cell Line Bank (KCLB), Millipore, National Cell Bank of Iran (NCBI_Iran), National Cancer Institute - Developmental Therapeutics Program (NCI-DTP), NINDS Human Cell and Data Repository (NHCDR), NIH AIDS Reagent Program (NIH-ARP), NISES, RIKEN Bioresource Center Cell Bank (RCB), Royan Stem Cell Bank (RSCB), Tick Cell Biobank (TCB), Tohoku University cell line catalog (TKG), and Ximbio.
Discontinued Possibly Discontinued Possibly Discontinued
https://web.expasy.org/cellosaurus/CVCL_1953
Organism: Saguinus oedipus (Cotton-top tamarin)
Category: Transformed cell line
Comments: Virology: This cell line sheds the Epstein-Barr virus (EBV) strain B95-8 and is often used to transform human or other primates B lymphocytes., Characteristics: Was established by exposure to extracts of the 883L cell line (Cellosaurus=CVCL_6A87)., Group: Non-human primate cell line.
Proper citation: CLS Cat# 601102, RRID:CVCL_1953 Copy
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https://web.expasy.org/cellosaurus/CVCL_0030
Organism: Homo sapiens (Human)
Disease: Human papillomavirus-related endocervical adenocarcinoma
Category: Cancer cell line
Comments: Miscellaneous: HeLa is the most frequent contributor to cell lines contamination., Anecdotal: Was flown since the 1960s on at least ten different space missions: Korabl-Sputnik-2, Vostok-1, Vostok-4, Vostok-5 and Vostok-6, Voshkod 1 and Zond-5, Discoverer XVIII, Progress M-35/Mir and Shuttle STS-89., Anecdotal: The HeLa cell line and its story inspired Australian artist Cynthia Verspaget to embark in 2003 on a artistic project 'The Anarchy Cell Line' (TAnCL) where she mixed her blood with HeLa cells. This work later spawned a PhD thesis (CelloPub=CLPUB00376) where among other things she makes the observation that two main taxonomical distinctions present in the zombie, living/dead and human/nonhuman, are also present in the HeLa cell line., Anecdotal: The fascinating story of the HeLa cell line and of Henrietta Lacks from whom these cells originate are described in the book of Rebecca Skloot (CelloPub=CLPUB00377)., Anecdotal: The HeLa cell line which was established in February 1951 is the oldest human immortal cell line., Virology: Not susceptible to infection by SARS coronavirus 2 (SARS-CoV-2) (COVID-19) (PubMed=33389257)., Virology: HeLa has 5 five HPV18 integration sites: three on normal chromosomes 8 at 8q24 and two on derivative chromosomes, der(5)t(5;22;8)(q11;q11q13;q24) and der(22)t(8;22) (q24;q13)., Population: African American., Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982)., Part of: MD Anderson Cell Lines Project., Part of: Human Protein Atlas, Cell Atlas panel., Part of: COSMIC cell lines project., Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE)., Group: Space-flown cell line (cellonaut).
Proper citation: CLS Cat# 300194, RRID:CVCL_0030 Copy
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https://web.expasy.org/cellosaurus/CVCL_0058
Organism: Homo sapiens (Human)
Disease: Human papillomavirus-related endocervical adenocarcinoma
Category: Cancer cell line
Comments: Anecdotal: The 'S' series of HeLa clones was named after Dr. Florence Sabin., Virology: Has at least 4 five HPV18 integration sites in the genome (PubMed=26550473)., Population: African American., Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982)., Part of: ENCODE project common cell types; tier 2.
Proper citation: CLS Cat# 300384, RRID:CVCL_0058 Copy
Contaminated Discontinued
https://web.expasy.org/cellosaurus/CVCL_1906
Organism: Homo sapiens (Human)
Disease: Human papillomavirus-related endocervical adenocarcinoma
Category: Cancer cell line
Comments: Virology: Not susceptible to infection by SARS coronavirus 2 (SARS-CoV-2) (COVID-19) (PubMed=33389257)., Population: African American., Part of: KuDOS 95 cell line panel., Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=4864103; PubMed=5641128; PubMed=566722; PubMed=1246601; PubMed=20143388). Originally thought to originate from a 56 year old male patient with a laryngeal carcinoma..
Proper citation: CLS Cat# 300397, RRID:CVCL_1906 Copy
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https://web.expasy.org/cellosaurus/CVCL_0358
Organism: Mus musculus (Mouse)
Disease: Mouse reticulum cell sarcoma
Category: Cancer cell line
Comments: Part of: Tumor Immunology Bank (TIB) collection from Salk (transferred to ATCC in 1981).
Proper citation: CLS Cat# 400220, RRID:CVCL_0358 Copy
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https://web.expasy.org/cellosaurus/CVCL_0346
Organism: Homo sapiens (Human)
Disease: Neuroblastoma
Category: Cancer cell line
Comments: Characteristics: Neuroblastic type (N-type)., Population: Caucasian., Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Proper citation: CLS Cat# 300148, RRID:CVCL_0346 Copy
Contaminated Discontinued Discontinued Discontinued Possibly Discontinued
https://web.expasy.org/cellosaurus/CVCL_0372
Organism: Homo sapiens (Human)
Disease: Human papillomavirus-related endocervical adenocarcinoma
Category: Cancer cell line
Comments: Population: African American., Part of: KuDOS 95 cell line panel., Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=4864103; PubMed=5641128; PubMed=1246601; PubMed=20143388). Originally thought to originate from an epidermal carcinoma of the mouth..
Proper citation: CLS Cat# 300446, RRID:CVCL_0372 Copy
Contaminated
https://web.expasy.org/cellosaurus/CVCL_5878
Organism: Homo sapiens (Human)
Disease: Clear cell renal cell carcinoma
Category: Cancer cell line
Comments: Problematic cell line: Contaminated. KTCTL-2 and KTCTL-30 have been shown to be identical (CLS; on the basis of STR profile)..
Proper citation: CLS Cat# 300250, RRID:CVCL_5878 Copy
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https://web.expasy.org/cellosaurus/CVCL_0421
Organism: Bos taurus (Bovine)
Category: Spontaneously immortalized cell line
Comments: Virology: Not susceptible to infection by wild-type and vaccinal strains of myxoma virus (MYXV) (PubMed=17900332)., Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
Proper citation: CLS Cat# 600396, RRID:CVCL_0421 Copy
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https://web.expasy.org/cellosaurus/CVCL_0440
Organism: Homo sapiens (Human)
Category: Finite cell line
Comments: Virology: Not susceptible to infection by SARS coronavirus 2 (SARS-CoV-2) (COVID-19) (PubMed=33389257)., Senescence: Capable of attaining 42-46 population doublings before the onset of senescence (ATCC=CCL-171). Senesces at 26 PDL (PubMed=17395773)., Biotechnology: Used for the production of the live zoster vaccine (Trade name: Zostavax)., Biotechnology: Used for the production of the live varicella virus vaccine (Trade name: Varivax)., Biotechnology: Used for the production of the Hepatitis A vaccines Avaxim, Epaxal, Havrix and Vaqta., Biotechnology: Used for the production of the Human Diploid Cell Vaccine (HDCV) against rabies (Trade name: Imovax Rabies)., Group: Vaccine production cell line.
Proper citation: CLS Cat# 300395, RRID:CVCL_0440 Copy
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https://web.expasy.org/cellosaurus/CVCL_0594
Organism: Mus musculus (Mouse)
Category: Spontaneously immortalized cell line
Comments: Miscellaneous: PubMed=23430347 has a different value for STR 6-4 (14.3) than that of NIST (15.3) due to a change in the marker motif (personal communication of Almeida, Jamie L.)., Miscellaneous: PubMed=23430347 has a different value for STR 4-2 (19.3) than that of NIST (19.3,20.3) due to a change in the stutter rules (personal communication of Almeida, Jamie L.)., Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982)., Part of: ENCODE project mouse cell lines.
Proper citation: CLS Cat# 400101, RRID:CVCL_0594 Copy
Discontinued Discontinued
https://web.expasy.org/cellosaurus/CVCL_0462
Organism: Mus musculus (Mouse)
Category: Spontaneously immortalized cell line
Comments: Miscellaneous: PubMed=23430347 has a different value for STR 6-4 (16) than that of NIST (17,18) due to a change in the marker motif (personal communication of Almeida, Jamie L.)., Anecdotal: First established continuous cell line., Virology: Not susceptible to infection by SARS coronavirus 2 (SARS-CoV-2) (COVID-19) (PubMed=33389257)., Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982)., Group: Space-flown cell line (cellonaut).
Proper citation: CLS Cat# 400260, RRID:CVCL_0462 Copy
Possibly Discontinued Possibly Discontinued
https://web.expasy.org/cellosaurus/CVCL_4032
Organism: Mus musculus (Mouse)
Disease: Mouse multiple myeloma
Category: Cancer cell line
Comments: Miscellaneous: PubMed=23430347 has a different value for STR 6-4 (17,18) than that of NIST (18,19) due to a change in the marker motif (personal communication of Almeida, Jamie L.)., Group: Hybridoma fusion partner cell line.
Proper citation: CLS Cat# 400118, RRID:CVCL_4032 Copy
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https://web.expasy.org/cellosaurus/CVCL_0514
Organism: Potorous tridactylus (Potoroo)
Category: Spontaneously immortalized cell line
Comments: Karyotypic information: As the diploid chromosome number of P.tridactylus is quite small (2n=12), this cell line is suited to the study of mitosis and to easily visualize the chromosomes under a microscope., Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982)., Group: Marsupial cell line.
Proper citation: CLS Cat# 608316, RRID:CVCL_0514 Copy
Contaminated
https://web.expasy.org/cellosaurus/CVCL_8262
Organism: Homo sapiens (Human)
Disease: Lung small cell carcinoma
Category: Cancer cell line
Comments: Population: Caucasian., Problematic cell line: Contaminated. Shown to be a SCLC-21H (or SCLC-22H) derivative (PubMed=10508494; PubMed=20143388)..
Proper citation: CLS Cat# 300177, RRID:CVCL_8262 Copy
Possibly Discontinued
https://web.expasy.org/cellosaurus/CVCL_2710
Organism: Homo sapiens (Human)
Category: Transformed cell line
Comments: Population: Caucasian., Part of: Human variation panel., Part of: Genetic Testing Reference Material (GeT-RM) samples.
Proper citation: CLS Cat# 300318, RRID:CVCL_2710 Copy
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https://web.expasy.org/cellosaurus/CVCL_0549
Organism: Spodoptera frugiperda (Fall armyworm)
Category: Spontaneously immortalized cell line
Comments: Caution: The SfRV rhabdovirus found in Sf9 cells of ATCC CRL-1711 lot 5807852 (PubMed=24672045) does not seem to be expressed in CRL-1711 lot 5814 from 1987 (PubMed=28423032). The SfRV genome is integrated in the Sf9 genome., Anecdotal: Have been flown in space on shuttle flights STS-50 (USML-1), STS-54 and STS-57 (Spacehab-1) to study growth in microgravity (PubMed=8050503)., Karyotypic information: Heterogeneous, contains a mixture of diploid and tetraploid cells., Biotechnology: Used for the production of the Novavax SARS-CoV-2 (COVID-19) vaccine (Trade name: NVX-CoV2373) (DrugBank=DB15810). The cell line is used to produce the recombinant SARS-CoV-2 spike protein rSARS-CoV-2 which is the active part of the vaccine formulation., Group: Vaccine production cell line., Group: Space-flown cell line (cellonaut)., Group: Recombinant protein production insect cell line., Group: Insect cell line.
Proper citation: CLS Cat# 604328, RRID:CVCL_0549 Copy
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https://web.expasy.org/cellosaurus/CVCL_0059
Organism: Chlorocebus sabaeus (Green monkey)
Category: Spontaneously immortalized cell line
Comments: Anecdotal: Verda reno means green kidney in Esperanto and Vero means truth also in Esperanto., Virology: Susceptible to infection by SARS coronavirus 2 (SARS-CoV-2) (COVID-19). But Vero C1008 (often known as Vero E6) (Cellosaurus=CVCL_0574) seems to be more appropriate for amplification and quantification (PubMed=32511316; PubMed=33389257)., Virology: Susceptible to infection by SARS coronavirus (SARS-CoV). Produces a lytic infection (PubMed=15731278; PubMed=16494729)., Biotechnology: Used for the production of the Sinovax SARS-CoV-2 (COVID-19) vaccine (Trade name: CoronaVac; also known as PiCoVacc) (DrugBank=DB15806). The cell line is used to produces the inactivated SARS-CoV-2 virus strain CN02 (PubMed=32376603)., Biotechnology: Used for the production of the Bharat Biotech SARS-CoV-2 (COVID-19) vaccine (Trade name: Covaxin; also known as BBV152) (DrugBank=DB15847). The cell line is used to produces a inactivated SARS-CoV-2 virus strain., Biotechnology: Used for the production of the tetravalent dengue vaccine (Trade Name: Dengvaxia)., Biotechnology: Used for the production of the live smallpox (vaccinia) vaccine (Trade name: ACAM2000)., Biotechnology: Used for the production of the live oral rotavirus vaccine (Trade Name: Rotarix)., Biotechnology: Used for the production of the Chromatographically Purified Rabies Vaccine (CPRV)., Biotechnology: Used for the production of the Purified Vero-cell Rabies Vaccine (PVRV) (Trade name: VERORAB)., Biotechnology: Used for the production of the inactivated poliovirus vaccine (Trade name: Imovax Polio)., Biotechnology: Used for the production of the Japanese encephalitis virus (JEV) vaccine (Trade name: IXIARO/JESPECT)., Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982)., Group: Vaccine production cell line., Group: Non-human primate cell line.
Proper citation: CLS Cat# 605372, RRID:CVCL_0059 Copy
Possibly Discontinued
https://web.expasy.org/cellosaurus/CVCL_2874
Organism: Mus musculus (Mouse)
Disease: Mouse fibrosarcoma
Category: Cancer cell line
Proper citation: CLS Cat# 305165, RRID:CVCL_2874 Copy
Contaminated Contaminated Discontinued Discontinued
https://web.expasy.org/cellosaurus/CVCL_0238
Organism: Homo sapiens (Human)
Disease: Human papillomavirus-related endocervical adenocarcinoma
Category: Cancer cell line
Comments: Population: African American., Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=4864103; PubMed=5641128; PubMed=1246601; PubMed=20143388; PubMed=21656536). Originally thought to originate from normal hepatic cells obtained from a liver biopsy of an adult..
Proper citation: CLS Cat# 300139, RRID:CVCL_0238 Copy
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Data set from Kravitz, Owen and Kretizer's 2012 paper "Optogenetic identification of striatal projection neuron subtypes during in vivo recordings."
