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URL: http://www.wormbase.org/db/get?name=WBStrain00063892
Proper Citation: RRID:WB-STRAIN:WBStrain00063892
Description: Caenorhabditis elegans with name EMPTY from WB.
Species: Caenorhabditis elegans
Synonyms: EMPTY
Notes: [2025-09-19T16:40:52.676Z WBPerson712] New Strain: MQ742 clk-2(C772Y-A828T) Hekimi lab To identify suppressors of clk-2(qm37) lethality at 25C, we screened ~200 000 haploid genomes in the F2 generation and ~110 000 haploid genomes in the F3 generation, isolating eight suppressor mutations. All eight were kept at 25C, outcrossed with dpy-17(e164) clk-2(qm37) III, and found to be dominant and linked to LGIII. Two mapped to a 0.5 cM interval of LGIII between sma-3 and unc-36 by three-factor mapping, suggesting intragenic suppression. Sequencing of the clk-2 locus confirmed all eight as intragenic suppressors, as well as in the remaining 6 suppressors. All 8 suppressors were found to be intragenic transitions (G A, or C T). Six suppressors caused an A828T substitution, one an A828V substitution, and one a S859N substitution (Fig. 1A). DB Reference ID: WBPaper00068607
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No rating or validation information has been found for Caenorhabditis elegans with no genotype reported.
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Source: Integrated Animals
Source Database: WormBase (WB)
Data set from Kravitz, Owen and Kretizer's 2012 paper "Optogenetic identification of striatal projection neuron subtypes during in vivo recordings."
