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URL: http://www.wormbase.org/db/get?name=WBStrain00040328
Proper Citation: RRID:WB-STRAIN:WBStrain00040328
Description: Caenorhabditis elegans with name gsr-1(tm3574)/qC1 dpy-19(e1259) glp-1(q339) nIs281 III. from WB.
Species: Caenorhabditis elegans
Synonyms: gsr-1(tm3574)/qC1 dpy-19(e1259) glp-1(q339) nIs281 III.
Notes: Made_by: Francisco Jos Naranjo-Galindo|"nIs281 [myo-2::RFP] integrated near qC1. Recombination between nIs281 and qC1 has been reported. Fails to complemement all markers on qC1. Heterozygotes are WT and segregate WT, Dpy Sterile, and tm3574 homozygotes. gsr-1(tm3574) is embryonic lethal. gsr-1(m+,z-) animals are viable and reach adulthood with no visible phenotype and lay eggs that invariably arrest at the pregastrula stage; they are slightly short-lived, have increased mitochondrial fragmentation, decreased mitochondrial DNA content and have induced mitochondrial UPR measured by hsp-6::GFP levels. gsr-1(m-,z-) have aberrant perinuclear distribution of interphasic chromatin. NOTE: The RFP-labeled balancer is reportedly not entirely stable in this strain and will occasionally segregate recombinants of two types: sterile RFP+ animals (most likely homozygous qC1 [nIs281] worms that are able to grow to adulthood but do not develop germline), and non-RFP animals that lay viable progeny. Maintain by picking fertile RFP+ animals and confirming that non-RFP progeny lay 100% arrested embryos. Reference: Mora-Lorca JA, et al. Free Radic Biol Med. 2016 Jul;96:446-61."
Affected Gene: WBGene00001078(dpy-19)|WBGene00001609(glp-1)|WBGene00008117(gsr-1)
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Source: Integrated Animals
Source Database: WormBase (WB)
Data set from Kravitz, Owen and Kretizer's 2012 paper "Optogenetic identification of striatal projection neuron subtypes during in vivo recordings."
