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URL: http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=598973845
Proper Citation: RRID:RRRC_00932
Description: Rattus norvegicus with name SD-Gfapem1Mes+/- from RGD.
Species: Rattus norvegicus
Notes: The targeted mutation in the rat GFAP gene was based on the severity and frequency of the R239H mutation in human disease. The CRISPR/Cas9 system was used to mediated knockin of point mutation (R237H) to Sprague-Dawley embryos. The current background srain is Crl:CD (SD). This mutant strain serves as a model for Alexander disease. knockins have post-weaning failure to thrive and ~10% mortality by 12 weeks, but afterwards are viable and can breed . The strain is now deposited at Rat Resource and Research Center
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Source: Integrated Animals
Source Database: Rat Resource and Research Center (RRRC)
Data set from Kravitz, Owen and Kretizer's 2012 paper "Optogenetic identification of striatal projection neuron subtypes during in vivo recordings."
