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URL: https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12904908
Proper Citation: RRID:RGD_12904908
Description: Rattus norvegicus with name SD-Ldlrem1Sage from RGD.
Species: Rattus norvegicus
Notes: In this ZFN induced model, a total of 337 bp were deleted at the junction of intron 3 and exon 4 (on chromosome 8), and 4 bp ccgt were inserted rat Ldlr gene on chromosome 8. Homozygous knockout rats display loss of LDLR protein via Western blot. Homozygous knockout rats have increased body weight as compared to wild type. Homozygous knockout rats show significantly elevated serum cholesterol levels. Horizon Discovery
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Source: Integrated Animals
Source Database: Rat Genome Database (RGD)
Data set from Kravitz, Owen and Kretizer's 2012 paper "Optogenetic identification of striatal projection neuron subtypes during in vivo recordings."
