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URL: https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=626170595
Proper Citation: RRID:RGD_626170595
Description: Rattus norvegicus with name LE-Syngap1em2Sidb from RGD.
Species: Rattus norvegicus
Notes: This allele has a deletion of the C2/GAP domain of Syngap1 and was generated by Sigma Advanced Genetic Engineering (SAGE) Labs (St. Louis, MO, US). Zinc-finger nucleases (ZFNs) designed to target Syngap1 exons 8–12 were microinjected into the pronucleus of fertilized, single-cell Long Evans (LE) embryos. A 3,584-bp selective deletion and 3-bp insertion were confirmed by sequencing, which resulted in a mutant protein that was 377 amino acids smaller than endogenous SYNGAP1. Simons Initiative for the Developing Brain (SIDB), Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh EH8 9XD, UK. Contact SIDB Scientific Officer for enquiries on rat distribution ([email protected]).
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Source: Integrated Animals
Source Database: Rat Genome Database (RGD)
Data set from Kravitz, Owen and Kretizer's 2012 paper "Optogenetic identification of striatal projection neuron subtypes during in vivo recordings."
