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URL: https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=625777899
Proper Citation: RRID:RGD_625777899
Description: Rattus norvegicus with name WI-Ugt2em1Yakaz from RGD.
Species: Rattus norvegicus
Notes: To produce Ugt2 cluster (∼762-kb) KO rats, two gRNAs with target sites upstream of Ugt2a1 and the coding region of Ugt2b31-like were injected into rat fertilized eggs. A knockout strain with Ugt2 cluster mutation carried concatenation of the genomic sequence upstream of Ugt2a1, a 102-bp insertion, and the Ugt2b31-like region. The F2 homozygous rats showed decreased gemfibrozil glucuronidation activity in the liver. The result suggested the functional deletion of rat Ugt2 genes in the Ugt2-KO rats.
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Source: Integrated Animals
Source Database: Rat Genome Database (RGD)
Data set from Kravitz, Owen and Kretizer's 2012 paper "Optogenetic identification of striatal projection neuron subtypes during in vivo recordings."
