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URL: https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12904912
Proper Citation: RRID:RGD_12904912
Description: Rattus norvegicus with name SD-Lepem1Sage-/- from RGD.
Species: Rattus norvegicus
Notes: This ZFN model possesses a 151 bp deletion spanning exon 1/intron 1 junction of Leptin gene. Homozygous knockout rats display loss of Leptin protein via Western blot. Homozygous knockout rats demonstrate significant weight gain compared to wild type littermates. Homozygous knockout rats show significantly elevated serum cholesterol levels Inotiv
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Source: Integrated Animals
Source Database: Rat Genome Database (RGD)
Data set from Kravitz, Owen and Kretizer's 2012 paper "Optogenetic identification of striatal projection neuron subtypes during in vivo recordings."
