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Proper Citation: RRID:MGI:5014832
Description: Allele Detail: Targeted This is a legacy resource.
Species: Mus musculus
Notes: Allele Detail: Targeted This is a legacy resource.
Phenotype: adipose tissue inflammation, decreased cellular sensitivity to gamma-irradiation, vasculitis, premature death, increased osteosarcoma incidence, lung inflammation, liver inflammation, liver cirrhosis, increased tumor incidence, increased splenocyte proliferation, increased ovary tumor incidence, increased lung adenoma incidence, increased intestinal adenoma incidence, increased inflammatory response, increased histiocytic sarcoma incidence, increased hibernoma incidence, increased circulating tumor necrosis factor level, absent optic nerve, abnormal lymphocyte morphology, abnormal common myeloid progenitor cell morphology, abnormal coat/ hair morphology, abnormal cell cycle, abnormal Peyer's patch morphology, increased T cell derived lymphoma incidence, increased B cell derived lymphoma incidence, enlarged spleen, exencephaly, increased circulating interleukin-6 level, extramedullary hematopoiesis, hepatic steatosis, increased brain size, increased cell proliferation, increased circulating interferon-gamma level, increased circulating interleukin-3 level, increased circulating interleukin-5 level, decreased thymocyte apoptosis
Affected Gene: Trp53
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Source: Integrated Animals
Source Database: MGI, Mouse Genome Informatics MGI
Data set from Kravitz, Owen and Kretizer's 2012 paper "Optogenetic identification of striatal projection neuron subtypes during in vivo recordings."
