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Proper Citation: RRID:MGI:3706987
Description: Allele Detail: Targeted This is a legacy resource.
Species: Mus musculus
Notes: Allele Detail: Targeted This is a legacy resource.
Phenotype: decreased circulating insulin level, increased insulin sensitivity, improved glucose tolerance, decreased interleukin-6 secretion, increased carcinoma incidence, decreased interleukin-1 beta secretion, increased gastrointestinal tumor incidence, decreased tumor necrosis factor secretion, decreased fat cell size, premature death, weight loss, abnormal large intestine crypts of Lieberkuhn morphology, colonic necrosis, abnormal intestinal epithelium morphology, decreased gonadal fat pad weight, increased energy expenditure, rectal hemorrhage, increased susceptibility to induced colitis, increased colon adenoma incidence, decreased circulating tumor necrosis factor level, abnormal glucose homeostasis, decreased neuron apoptosis, decreased cerebral infarction size, abnormal cytokine secretion, decreased splenocyte proliferation, abnormal cellular extravasation, decreased angiogenesis, decreased susceptibility to bacterial infection induced morbidity/mortality, decreased susceptibility to kidney reperfusion injury, increased food intake, CNS ischemia, decreased susceptibility to hepatic steatosis, increased adipocyte glucose uptake, weight loss, abnormal enterocyte morphology, premature death, rectal hemorrhage, decreased circulating leptin level, increased insulin secretion
Affected Gene: Tlr2
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Source: Integrated Animals
Source Database: MGI, Mouse Genome Informatics MGI
Data set from Kravitz, Owen and Kretizer's 2012 paper "Optogenetic identification of striatal projection neuron subtypes during in vivo recordings."
