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Proper Citation: RRID:MGI:3695413
Description: Allele Detail: Spontaneous This is a legacy resource.
Species: Mus musculus
Notes: Allele Detail: Spontaneous This is a legacy resource.
Phenotype: premature hair loss, decreased IgG level, alopecia, decreased T cell number, increased eosinophil cell number, thick epidermis stratum basale, decreased immunoglobulin level, abnormal spleen B cell follicle morphology, scaly skin, parakeratosis, abnormal lung interstitium morphology, decreased CD4-positive, alpha beta T cell number, abnormal lymph node morphology, increased IgM level, scaly skin, extramedullary hematopoiesis, lung inflammation, abnormal tongue squamous epithelium morphology, increased bone marrow cell number, increased mast cell number, thick epidermis, epidermal hyperplasia, enlarged spleen, skin lesions, thick epidermis, acanthosis, lymph node inflammation, extramedullary hematopoiesis, folliculitis, weight loss, decreased IgE level, increased keratinocyte apoptosis, thick eyelids, mixed cellular infiltration to dermis, esophageal inflammation, abnormal hair follicle morphology, abnormal spleen morphology, increased mast cell number, stomach inflammation, increased keratinocyte proliferation, abnormal angiogenesis, abnormal spleen white pulp morphology, abnormal lymph node morphology, postnatal growth retardation, abnormal liver morphology, abnormal synovial joint capsule morphology, large lymphoid organs, abnormal immune system organ morphology, increased keratinocyte apoptosis, skin edema, joint inflammation, abnormal stomach epithelium morphology, increased eosinophil cell number, abnormal spleen white pulp morphology, skin lesions, hyperkeratosis, abnormal esophageal epithelium morphology, abnormal epidermis stratum granulosum morphology, absent Peyer's patches, abnormal liver morphology, abnormal esophageal epithelium morphology, dermatitis, abnormal epidermal layer morphology, decreased B cell number, increased pruritus, mixed cellular infiltration to dermis, hyperkeratosis, abnormal coat appearance, abnormal hair shaft morphology, parakeratosis, absent spleen germinal center, absent spleen marginal zone, premature hair loss, female infertility, abnormal dermal layer morphology, extramedullary hematopoiesis, abnormal epidermis stratum corneum morphology, scaly skin, decreased IgA level, enlarged spleen, abnormal mesenteric lymph node morphology, abnormal humoral immune response, increased keratinocyte apoptosis, abnormal epidermis stratum basale morphology, reddish skin, reduced male fertility, reddish skin, decreased IgE level, mixed cellular infiltration to dermis
Affected Gene: Sharpin
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Source: Integrated Animals
Source Database: MGI, Mouse Genome Informatics MGI
Data set from Kravitz, Owen and Kretizer's 2012 paper "Optogenetic identification of striatal projection neuron subtypes during in vivo recordings."
