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Proper Citation: RRID:MGI:3583763
Description: Allele Detail: Targeted This is a legacy resource.
Species: Mus musculus
Notes: Allele Detail: Targeted This is a legacy resource.
Phenotype: increased circulating leptin level, small pituitary intermediate lobe, abnormal circulating glucose level, decreased body weight, abnormal glucose homeostasis, decreased glycogen level, hyperglycemia, small pancreatic islets, premature death, impaired glucose tolerance, insulin resistance, hyperglycemia, decreased birth body size, increased circulating insulin level, decreased pancreatic beta cell mass, decreased body weight, polyuria, polydipsia, decreased oocyte number, decreased gonadotroph cell number, decreased circulating testosterone level, decreased circulating prolactin level, decreased circulating progesterone level, decreased circulating luteinizing hormone level, decreased circulating estradiol level, absent corpus luteum, abnormal ovarian follicle morphology, abnormal ovulation, abnormal circulating hormone level, small pituitary gland, small ovary, reduced male fertility, reduced female fertility, polyphagia, obese, increased total body fat amount, abnormal mating frequency, abnormal glucose homeostasis, abnormal oogenesis, impaired ovarian folliculogenesis, impaired glucose tolerance, abnormal energy homeostasis, absent estrous cycle, anovulation, female infertility, abnormal pancreatic beta cell morphology, abnormal lipid homeostasis, weight loss, hyperglycemia, decreased pancreatic beta cell number, abnormal circulating insulin level, premature death, insulin resistance, increased circulating insulin level, hyperglycemia, decreased pancreatic beta cell mass
Affected Gene: Irs2
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Source: Integrated Animals
Source Database: MGI, Mouse Genome Informatics MGI
Data set from Kravitz, Owen and Kretizer's 2012 paper "Optogenetic identification of striatal projection neuron subtypes during in vivo recordings."
