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Curated information on nuclear receptors, ligands and co-regulators from the Nuclear Receptor Signaling Atlas (NURSA). As of March 20, 2020, NURSA is succeeded by the Signaling Pathways Project (SPP). All NURSA-biocurated transcriptomic datasets have been preserved for data mining in SPP. All non-transcriptomic dataset NURSA content will be transferred to dkNET, with whom we are evaluating options for archiving this content.
(last updated: Mar 24, 2020)
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Information Molecule| DOI | Symbol | Name | Type | Synonyms | Description | Reference | |||
|---|---|---|---|---|---|---|---|---|---|
| 10.1621/P2IER7XI8L | RREB1 | Ras-responsive element binding protein | Coregulator | Ras-responsive element binding protein was isolated as a corepressor for androgen receptor (AR), a member of the nuclear receptor superfamily of transcription factors. | PMID:17550981 | ||||
| 10.1621/7ROVFK8H65 | VAV3 | Vav 3 oncogene | Coregulator | Vav3 is a Rho GTPase guanine nucleotide exchange factor that was characterized as a coactivator through its ability to potentiate androgen receptor transcriptional activity. | PMID:16384856 | ||||
| 10.1621/5X5KCOJ63S | CMTM2 | Androgen receptor corepressor-19 kDa | Coregulator | ARR19 is a leucine-rich protein shown to repress the transcriptional activity of the androgen receptor (AR) by a mechanism involving recruitment of a histone deacetylase. | PMID:14576337 | ||||
| 10.1621/78CF2792E0 | CP775 | CP-775146 | Ligand | ||||||
| 10.1621/78C72792E0 | Fex | Fexaramine | Ligand | ||||||
| 10.1621/2LWZGZWA3J | TRIP10 | Thyroid hormone receptor interactor 10 | Coregulator | An early screen of thyroid receptor (TR) interacting proteins (TRIPs) yielded a large number of factors, of which TRIP10 is one. TRIP10 is a member of the FNBP1 family of proteins which contains FCH, FBH and SH3 domains. | PMID:7776974 | ||||
| 10.1621/VL1SBUWRLZ | GADD45GIP1 | CR6-interacting Factor 1 | Coregulator | CRIF1 is a nuclear protein that interacts with the Gadd4 family of proteins and participates in the regulation of the cell cycle. CRIF1 was characterized as a coregulator through its inhibition of Nur77 transactivation. | PMID:15459248 | ||||
| 10.1621/EG3FENHR1D | SAFB2 | Scaffold attachment factor B2 | Coregulator | The highly related nuclear matrix proteins and scaffold attachment factors, SAF-B2 and SAF-B1, enhance tamoxifen antagonism of estrogen-induced ER-mediated transactivation. | PMID:12660241 | ||||
| 10.1621/78CB2792E0 | DY131 | DY131 | Ligand | ||||||
| 10.1621/78CA2792E0 | AG035029 | AG035029 | Ligand | ||||||
| 10.1621/LSYWZR4E2A | CD4409 | CD4409 | Ligand | ||||||
| 10.1621/SQJ2VWFWMV | SIN3B | SIN3 homolog B, transcriptional regulator (yeast) | Coregulator | Members of the SIN3 family of transcriptional corepressors have well characterized roles in the negative regulation of transcription by nuclear receptors and other transcription factors. | PMID:9139820 PMID:9734811 | ||||
| 10.1621/6S3G2BUCCZ | GMEB2 | Glucocorticoid modulatory element binding protein 2 | Coregulator | GMEB proteins interact with a glucocorticoid modulatory element upstream of the rat tyrosine aminotransferase gene. Along with GMEB-1, GMEB-2 has been characterized as a coactivator of the glucocorticoid receptor (GR). | PMID:10523663 PMID:10894151 | ||||
| 10.1621/T3T83IH3EU | ZNF653 | Zinkfinger protein 67 kDa | Coregulator | Zip67 is a zinc finger protein cloned in a screen for proteins interacting with the C terminus of the orphan nuclear receptor SF-1. | PMID:12920234 | ||||
| 10.1621/7JN5RPD1G7 | nr5a4 | Fushi tarazu-F1 (FF1B) | Nuclear Receptor | The zebrafish ff1b gene encodes the orphan nuclear receptor ff1b, which shows strong homology to mammalian SF-1, of the Fushi tarazu-subfamily of nuclear receptor transcription factors. ff1b is required for the development of the steroidogenic component of the zebrafish interrenal organ. ff1b is expressed in zebrafish in the developing rostral diencephalon and in the anterior regions of the pancreatic anlagen. | PMID:10704877 | ||||
| 10.1621/78DC2792E0 | MeCarbam | METHYL CARBAMATE | Ligand | ||||||
| 10.1621/W1XSFF1GQZ | ZK281 | ZK168281 | Ligand | ||||||
| 10.1621/DZ9ENDHKLS | R1881 | R1881 | Ligand | ||||||
| 10.1621/ZO4XC996TW | CD2314 | CD2314 | Ligand | ||||||
| 10.1621/9VJOTIG1ZP | RNF4 | Small nuclear RING finger protein | Coregulator | SNURF is a RING finger motif-containing protein that has been shown to enhance the transcriptional activity of a number of nuclear receptors | PMID:9479498 PMID:9710597 |
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