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The Human Islet Research Network (HIRN) helps to organize and support collaborative research related to the loss of functional beta cell mass in Type 1 Diabetes. The cell line view is a list of cell lines used by HIRN researchers. The "Cell Line Name" column links to information about individual cell lines.
(last updated: Jul 15, 2021)
Cell Physical Resource or Software Tool| Name | Research Resource Identifier | Cell Category | Species | Disease | Description | Reference | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| NKX2.1GFP/W-hESC | Stem Cell | human | Line with NKX2.1-GFP reporter. | PMID:28931519 | Female | human induced pluripotent stem cell line cell; embryonic stem cell line | ||||
| Highly purified alpha cells from single fetal non-diabetic sample (SE 3029) | Primary Cell | human | Cells isolated by intracellular staining for cell-specific hormone content and sorted by FACS. Transcriptome data available. | PMID:25931473 | pancreas | pancreatic A cell | ||||
| ND-1 (ND hiPSC Line 1) | Stem Cell | human | Derived from skin fibroblasts of a non-diabetic donor. | PMID:27163171 | human induced pluripotent stem cell line cell; induced pluripotent stem cell line | |||||
| Highly purified beta cells from single adult non-diabetic sample (SE ZEP055) | Primary Cell | human | Cells isolated by intracellular staining for cell-specific hormone content and sorted by FACS. Transcriptome data available. | PMID:25931473 | Female | pancreas | type B pancreatic cell | |||
| Highly purified beta cells from single adult non-diabetic sample (AAIB402A) | Primary Cell | human | Cells isolated by intracellular staining for cell-specific hormone content and sorted by FACS. Transcriptome data available. | PMID:25931473 | Male | pancreas | type B pancreatic cell | |||
| T1D-2 (T1D hiPSC Line 2) | Stem Cell | human | type 1 diabetes mellitus | Derived from skin fibroblasts of a T1D donor. | PMID:27163171 | human induced pluripotent stem cell line cell; induced pluripotent stem cell line | ||||
| INS-1 beta-cells stably expressing human TXNIP (INS-TXNIP) | Cell Line | rat | INS-1 cells were transfected with promoter reporter constructs containing the full-length human TXNIP promoter as well as different deletions/mutations. | PMID:26858253 | functional beta cell like cell | |||||
| Beta-TC-3 | RRID:CVCL_0172 | Cell Line | mouse | Islet-derived immortalized cell line. | PMID:27300767 | functional beta cell like cell | ||||
| Highly purified beta cells from single adult non-diabetic sample (SE ZA2357) | Primary Cell | human | Cells isolated by intracellular staining for cell-specific hormone content and sorted by FACS. Transcriptome data available. | PMID:25931473 | Male | pancreas | type B pancreatic cell | |||
| T1D-3 (T1D hiPSC Line 3) | Stem Cell | human | type 1 diabetes mellitus | Derived from skin fibroblasts of a T1D donor. | PMID:27163171 | human induced pluripotent stem cell line cell; induced pluripotent stem cell line | ||||
| Medalist -C Subject2 iPSC | Stem Cell | human | type 1 diabetes mellitus | Line derived from a subject with absent to mild diabetic complications. | PMID:26244933 | Male | human induced pluripotent stem cell line cell; induced pluripotent stem cell line | Authentication Method: embryoid body formation assay; Induction Method: reprogramming vector | ||
| EndoC-betaH1 | RRID:CVCL_L909 | Cell Line | human | Secretes insulin in response to glucose challenge. However, these cells don't produce nitric oxide in reponse to cytokines (IL-1, IFN-gamma, and TNF) in a manner consistent with human islets. They also fail to respond to endoplasmic reticulum stress activators such as thapsigargin. | PMID:26084699 | type B pancreatic cell | ||||
| Highly purified alpha cells from grouped fetal non-diabetic samples (SE 3650, 3648, 3647) | Primary Cell | human | Cells isolated by intracellular staining for cell-specific hormone content and sorted by FACS. Transcriptome data available. | PMID:25931473 | pancreas | pancreatic A cell | ||||
| Highly purified alpha cells from grouped fetal non-diabetic samples (SE 3646, 4810) | Primary Cell | human | Cells isolated by intracellular staining for cell-specific hormone content and sorted by FACS. Transcriptome data available. | PMID:25931473 | pancreas | pancreatic A cell | ||||
| Control6 iPSC | Stem Cell | human | Line derived from control subjects for comparison with Medalist -C and Medalist +C derived lines. | PMID:26244933 | Female | human induced pluripotent stem cell line cell; induced pluripotent stem cell line | Authentication Method: embryoid body formation assay; Induction Method: reprogramming vector | |||
| Highly purified alpha cells from single fetal non-diabetic sample (SE 4574) | Primary Cell | human | Cells isolated by intracellular staining for cell-specific hormone content and sorted by FACS. Transcriptome data available. | PMID:25931473 | pancreas | pancreatic A cell | ||||
| Medalist -C Subject5 iPSC | Stem Cell | human | type 1 diabetes mellitus | Line derived from a subject with absent to mild diabetic complications. | PMID:26244933 | Female | human induced pluripotent stem cell line cell; induced pluripotent stem cell line | Authentication Method: embryoid body formation assay; Induction Method: reprogramming vector | ||
| Diabetes-causing CD4 T cell clones from NOD mice | Primary Cell | mouse | type 1 diabetes mellitus | Isolated from non-obese diabetic (NOD) mice. These pathogenic CD4 T cells target peptide ligands that are formed by covalent crosslinking of proinsulin peptides to other peptides present in beta-cell secretory granules. | PMID:26912858 | CD4-positive, alpha-beta T cell | ||||
| InsB:9-23-specific human T-cell line (Clone 5) | Primary Cell | human | type 1 diabetes mellitus | T-cell line established from blood from an 18-y-old Caucasoid HLA-DQ8 homozygous man diagnosed with T1D at the age of 8 y. | PMID:28874533 | Male | T cell | |||
| Highly purified beta cells from single fetal non-diabetic sample (SE 3004) | Primary Cell | human | Cells isolated by intracellular staining for cell-specific hormone content and sorted by FACS. Transcriptome data available. | PMID:25931473 | pancreas | type B pancreatic cell |
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The NIDDK Information Network (dkNET) serves the needs of basic and clinical investigators by providing seamless access to large pools of data and research resources relevant to the mission of The National Institute of Diabetes Digestive and Kidney Diseases (NIDDK). dkNET is hosted at University of California San Diego, and is supported by NIH NIDDK grant 2U24DK097771-09.
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