dkNET community events and announcements in September, 2019
Dear dkNET Community,
dkNET provides updates on activities of interest to the NIDDK-supported community. You could keep up to date on these activities through our Twitter feed @dkNET_info, through our Community Calendar, or through dkNET e-mail list. If you have an event or funding opportunities you'd like to advertise, please contact us info_at_dknet.org.
- Three new views are released at dkNET this month! We have added three new views from the Human Islet Research Network (HIRN) community, including:
- HIRN: datasets. This view contains transcriptomics, genomics, proteomics, epigenomics, and metabolomics data generated by HIRN researchers.
- HIRN: protocols. A list of protocols used by HIRN researchers
- HIRN: constructs. A list of constructs used by HIRN researchers.
- Two new resource types added to dkNET Resource Reports: Plasmids and Biosamples! Now you can find resource information and RRIDs of Plasmids (register with Addgene) and Biosamples (registered with NCBI Biosamples, initially from the IIDP - Integrated Islet Distribution Program) via dkNET Resource Reports!
- More than 52 research tools have been added to dkNET this month, including:
- SynGO (RRID:SCR_017330) is evidence-based, expert-curated knowledge base for synapse. It is the universal reference for synapse research and online analysis platform for interpretation of omics data. It is an interactive knowledge base that accumulates available research about synapse biology using Gene Ontology annotations to novel ontology terms.
- HmtVar (RRID:SCR_017288) is a manually curated database offering variability and pathogenicity information about mtDNA variants. It contains human mitochondrial variants data of healthy and diseased subjects.
- Scmap (RRID:SCR_017338) is a software tool for the unsupervised projection of single cell RNA-seq data. Used for projecting cells from scRNA-seq data set onto cell types or individual cells from other experiments.
Events in September, 2019
Sep. 10, 2019
NIDDK Workshop Registration Deadline: Alcoholic and Nonalcoholic Steatohepatitis: Pathogenesis and Mechanisms of Liver Injury Joint NIAAA-NIDDK Research Workshop
This research workshop is being jointly sponsored by the NIAAA and NIDDK with the aim of bringing together research investigators in these two fields, and summarizing the current state of the science of various pathophysiological mechanisms that lead to fatty liver injury. A particular focus will be on how the possible pathologic mechanism might be shared or distinct in alcoholic versus nonalcoholic fatty liver disease. Specific areas of research will include hepatocyte cell injury, modes of death including apoptosis, pyroptosis, and necroptosis, injury and stress pathways, lipid synthesis and metabolism, cytokines and immune signaling, the microbiome, genetic factors, systems biology and mechanisms of the complications of chronic fatty liver. The organizers of the Research Workshop plan to summarize the presentations and discussions as a manuscript for publication which will focus on the current most promising and challenging opportunities in research on the pathophysiology of alcoholic and nonalcoholic liver injury and how collaborations between these two research communities might best advance the understanding of these two similar but distinct liver diseases. Meeting dates: Sep. 16-17, 2019.
Location: Bethesda, MD, USA
More information: https://www.niddk.nih.gov/news/meetings-workshops/2019/alcoholic-and-nonalcoholic-steatohepatitis-2019
Sep. 16-20, 2019
MMPC Course: Glucose Clamping the Conscious Mouse: A Laboratory Course
2019 Research Advances for UCPPS: Informing the Next Generation of Clinical Studies
Urologic Chronic Pelvic Pain Syndrome (UCPPS) represents both Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) and Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS). The Research Advances for Urologic Chronic Pelvic Pain Syndrome: Informing the Next Generation of Clinical Studies meeting will provide a forum for exchange of seminal insights into UCPPS underlying mechanisms and clinical characteristics. The meeting will highlight findings from the Multidisciplinary Approach to the Study of Pelvic Pain (MAPP) Research Network and other investigators working in the UCPPS field, as well as work in other areas that may inform these efforts. Junior faculty conducting UCPPS research, as well as those new to UCPPS are encouraged to attend. Major themes will include identification of new treatment targets and therapies based on underlying mechanisms, patient sub-grouping strategies, new disease definitions and optimal outcome measures, and novel clinical trial designs. A central goal of the meeting is to support the translation of new insights into recommendations for developing future evidence-based clinical studies/trials for UCPPS and ultimately to improve patient care. Registration deadline: Sep. 17, 2019
Type 2 Diabetes Knowledge Portal Webinar Series
NIDDK Workshop Registration Deadline: Uncovering the Hidden Burden of Benign Genitourinary Conditions
The purpose of the workshop is to convene an interdisciplinary group of researchers and health professionals—including urologists and urogynecologists working in traditional benign urologic condition (BUC) silos, primary care providers, measurement and data scientists, basic scientists, economists, policy experts, public health professionals, and others—to answer key questions, including the following: What data are needed to understand the hidden burden of BUCs? How can these data be captured in a feasible manner to build a complete picture of the burden of BUCs? Are new tools needed for the data capture?
More information: https://www.niddk.nih.gov/news/meetings-workshops/2019/uncovering-the-hidden-burden-of-benign-genitourinary-conditions
Sep. 27-30, 2019
EMBO Workshop — Lipid function in health and disease
The program will combine biochemical, biophysical and cell biological approaches to lipid function and metabolism and move from basic science to cover lipids in health and disease. By trying to creatively present the attractiveness and breadth of the field, this EMBO Workshop will confront the speakers and the participants with the exciting challenges ahead.
2019 Mid-Atlantic Diabetes and Obesity Research Symposium
The 2019 Annual Mid-Atlantic Diabetes And Obesity Research Symposium is co-sponsored by the Diabetes, Endocrinology, and Obesity Branch (DEOB) at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH); the Mid-Atlantic Nutrition Obesity Research Center (NORC) at the Department of Medicine, University of Maryland School of Medicine (UM-SOM); and the Foundation for Advanced Education in the Sciences (FAES) at the NIH.
Location: Bethesda, MD, USA
More information: https://www.niddk.nih.gov/news/meetings-workshops/2019/midatlantic-diabetes-and-obesity-research-symposium-2019
Funding opportunities information and deadlines in September, 2019
Sep. 01, 2019
Funding Opportunity Application Due Date: MMPC MICROMouse Program
The MMPC MICROMouse Program is a competitive grants program awarding up to $75,000 (total costs) for one year to fund research projects that have the potential to enhance and advance the mission of the MMPC as a resource for scientists using mice to study diabetes and obesity. Any independent investigator, including post-doctoral fellows, is eligible to apply. A project must be either: 1) resource-development (e.g., develop, improve, miniaturize, teach, distribute, etc. phenotyping tests for use in mice); or 2) resource-related research (e.g., a new, currently unfunded project where results have potential impact for mouse centered research in diabetes or obesity, particularly those focused on broad biological questions that impact the ability of the MMPC to meet its goals). There is no formal deadline associated with MICROMouse applications, but applications will be reviewed quarterly (March 1, June 1, September 1, December 1) and therefore should be submitted accordingly.
More information: https://www.mmpc.org/shared/microMouse.aspx
NIH Funding Opportunity Application Due Date: 2020 NIH Director’s Early Independence Award (DP5 - Clinical Trial Optional)
Supports outstanding junior scientists with the intellect, scientific creativity, drive, and maturity launch independent research careers and bypass the traditional postdoctoral training period. Note: To be consistent with the updated NIH definition of Early Stage Investigators, eligible clinical training includes medical residency and clinical fellowships. (1) Complete doctoral degree or clinical training between June 1, 2018 and September 30, 2020 (2) In non-independent position at time of application (3) Single-PI applications only (4) Limited to two applications per institution (5) Up to $250,000 direct costs per year for up to 5 years.
More information: https://grants.nih.gov/grants/guide/rfa-files/RFA-RM-19-008.html
NIH Funding Opportunity Application Due Date: 2020 NIH Director's Pioneer Award (DP1 - Clinical Trial Optional)
Supports scientists with outstanding records of creativity pursuing new research directions to develop pioneering approaches to major challenges in biomedical and behavioral research.(1) Open to all career stages (2) Single-PI applications only (3) No preliminary data required (4) Must be new scientific research direction (5) $700,000 direct costs per year for 5 years.
More information: https://grants.nih.gov/grants/guide/rfa-files/RFA-RM-19-005.html
Sep. 20, 2019
NIH Funding Opportunity Application Due Date: 2020 NIH Director’s Transformative Research Award (R01 - Clinical Trial Optional)
Supports individuals or teams proposing projects that are inherently risky and untested but have the potential to create or overturn fundamental paradigms. (1) Open to all career stages (2) Open to individuals or teams (3) No preliminary data required (4) Flexible budgets.
More information: https://grants.nih.gov/grants/guide/rfa-files/RFA-RM-19-007.html
NIH Funding Opportunity Letter of Intent Due Date: Pilot Projects Investigating Understudied G Protein-Coupled Receptors, Ion Channels, and Protein Kinases (R03 Clinical Trial Not Allowed)
The goal of this funding opportunity announcement (FOA) for the Common Fund Program "Illuminating the Druggable Genome" (IDG; https://commonfund.nih.gov/idg/index) is to solicit applications for pilot projects on IDG-eligible understudied proteins (non-olfactory GPCRs, protein kinases, and ion channels) in order to study them beyond what the IDG’s Centers can accomplish and to validate and demonstrate the utility of IDG-generated reagents, data, and approaches. Awards will support the generation of additional data and tools around understudied protein(s) identified by the IDG Program to elucidate the function of these proteins in the context of human disease. Data collected and tools generated by these projects will enhance the overall goals of the IDG Program by demonstrating the quality and utility of IDG-generated data and reagents to the scientific community, increasing awareness of the IDG Program through use of IDG-generated resources, and/or extending the characterization of IDG-eligible proteins. The overall goal of the IDG Program is to catalyze research in areas of biology that are currently understudied but that have high potential to impact human health by (1) identifying biochemical, cellular, or animal model phenotypes for understudied proteins from druggable gene families, (2) enabling further investigation of those proteins by providing reagents and tools, and (3) generating, maintaining, and facilitating the use of a minable knowledge base.
More information: https://grants.nih.gov/grants/guide/rfa-files/RFA-RM-19-011.html