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dkNET community events and announcements in January, 2018

Dear dkNET Community,

dkNET provides updates on activities of interest to the NIDDK-supported community. You could keep up to date on these activities through our Twitter feed @dkNET_info, through our Community Calendar, or through dkNET e-mail list. If you have an event or funding opportunities you'd like to advertise, please contact us info_at_dknet.org.


dkNET Updates:

  • New research tools added to dkNET

Clinical Trials in Organ Transplantation (CTOT) (RRID:SCR_015859) is a project portal for a cooperative research program to improve short and long-term graft and patient survival. CTOT is an investigative consortium for conducting clinical and associated mechanistic studies that will lead to improved outcomes for transplant recipients.

Growing Gene and Cell Therapy Cooperative (RRID:SCR_015861) is a project portal for a collaboration between Boston Children’s Hospital, Cincinnati Children’s Hospital Medical Center, and the University of California Los Angeles with funding from NIH NCATS. It aims to support investigators to rapidly translate complex gene and cell therapies to early phase, investigator-initiated clinical trials.

Monogenic Diabetes Registry (RRID:SCR_015883) is a research project that aims to learn more about the number of people who have monogenic diabetes, why and how it happens, and how best to treat it. Any adult or child with a known genetic cause of diabetes may join the MODY Registry.

National Glycohemoglobin Standardization Program (RRID:SCR_015885) is a project that aims to standardize Hemoglobin A1c test results to those of the Diabetes Control and Complications Trial (DCCT) and United Kingdom Prospective Diabetes Study (UKPDS) which established the direct relationships between HbA1c levels and outcome risks in patients with diabetes.


Events in January, 2018

Jan. 21-25, 2018

Keystone Meeting: Bioenergetics and Metabolic Disease (J4) 

Obesity and type 2 diabetes are major drivers of chronic disease and premature death. A promising strategy to reduce obesity and improve metabolic health is through promoting energy expenditure via thermogenesis, including obligatory(accompanies all metabolic processes) and facultative (adaptive) mechanisms. Obesity and insulin resistance also lead to profound metabolic changes in various cells/tissues that contribute to tissue dysfunction. This conference brings together basic and clinical researchers from industry and academia focused on the study of cellular and organismal energy metabolism in the context of metabolic disease. A variety of approaches and topics will be featured, including: basic mechanisms of mitochondrial and cellular energetics; the emerging role of brown and beige fat in adaptive thermogenesis; central regulation of energy expenditure; and the effects of exercise on muscle andwhole-body metabolism. In addition to the plenary sessions, the meeting will feature workshops on emerging research areas and novel therapeutic opportunities. Overall, the goals of the conference are to: 1) Provide a cutting-edge understanding of the basic mechanisms that control cellular and whole-body energetics; 2) Discuss the physiological role of brown fat and other energy expenditure pathways in humans; 3) Consider novel strategies for increasing energy expenditure and combating metabolic disease; and 4) Engage attendees in critical discussions about important areas for future research.

Location: Keystone, CO, USA 

More information: http://www.keystonesymposia.org/index.cfm?e=web.meeting.program&meetingid=1566


Jan. 21-25, 2018

Keystone Symposia: Organ Crosstalk in Obesity and NAFLD 

Neural and humoral communication among peripheral organs and the brain is critical in coordinating whole body energy homeostasis in health and disease. Nutrient and hormone sensing take place in multiple organs with the central nervous system as a site of integration of these diverse signals, governing this coordination. Within this multi-organ framework, the liver occupies a central role in determining systemic glucose and lipid metabolism in obesity and clinically relevant metabolic pathophysiology, particularly non-alcoholic fatty liver disease (NAFLD) and fibrosis. Identification and characterization of the modes and consequences of organ cross-talk is essential to fill existing gaps in knowledge and to promote the development of therapeutic strategies to treat obesity and metabolic disease. This conference brings together experts in the novel, multidisciplinary evaluation of organ cross-talk, using innovative combinations of molecular, genetic, physiological, pharmacological and systems neuroscience approaches to: 1) Provide a unique and timely perspective, and 2) Inspire interactions directed toward basic, clinical and translational research in integrative metabolism. Finally, the joint staging of this conference in conjunction with the conference on “Bioenergetics and Metabolic Disease” will strategically leverage presentations targeting the biology of metabolism and nutrient availability in obesity with those focused on the biology of energy utilization. Taken together, this novel combination will provide a coherent, powerful and comprehensive understanding of and appreciation for the complex.
Location: Keystone, CO, USA 

Jan. 22-24, 2018

NIH Data Science Hackathon 

The NIH National Center for Biomedical Informatics (NCBI) will help out with a Data Science hackathon on the NIH campus in Bethesda, Maryland!  The hackathon will focus on general Data Science analyses including text, image and sequence processing. This event is for researchers, including students and postdocs, who have already engaged in the use of large datasets or in the development of pipelines for analyses from high-throughput experiments. Some projects are available to other non-scientific developers, mathematicians, or librarians. The event is open to anyone selected for the hackathon and willing to travel to the NIH campus.

Location: Bethesda, MD, USA

More information: https://dknet.org/about/dknetnews/1042


Jan. 29, 2018

Application Deadline: 2018 NIDDK Medical Student Research Program in Diabetes and Obesity 

The Medical Student Summer Research Program in Diabetes and Obesity is sponsored by the National Institutes of Health through the NIDDK and allows medical students to conduct research under the direction of an established scientist in the areas of diabetes, hormone action, physiology, islet cell biology, obesity or complications at an institution with one of the NIDDK-funded Diabetes Centers during the summer between the first and second year or second and third year of medical school. Please remember that you must work on your research for 2-3 months and you must participate in the research symposium in Nashville, TN on August 1-2, 2018 (travel funds provided).

More information: http://medicalstudentdiabetesresearch.org/


Jan. 31- Feb. 3, 2018

2018 Rachmiel Levine-Arthur Riggs Diabetes Research Symposium 

Location: Pasadena, CA, USA 

More information: https://www.cityofhope.org/research/levine-symposium


Funding opportunities information and deadlines in January, 2018

Jan. 2, 2018 

Funding Opportunity Letter of Intent Due Date: Catalyst Award in Diabetes, Endocrinology and Metabolic Diseases

The Catalyst Award in Diabetes, Endocrinology and Metabolic Diseases (Catalyst-DEMD) is designed to complement NIDDK's traditional, investigator-initiated grant programs by supporting individual scientists who propose pioneering and possibly transforming studies in DEMD topic areas. Applications should be focused on major scientific challenges, and have the potential to produce an unusually high impact on diseases and conditions that are central to the mission of NIDDK's Division of Diabetes, Endocrinology and Metabolic Diseases. To be considered responsive to this initiative, the proposed research must reflect new and novel scientific directions that are distinct from concepts and approaches being pursued in the investigator’s research program or elsewhere.

More information: https://grants.nih.gov/grants/guide/rfa-files/RFA-DK-17-011.html


Jan. 2, 2018 

Funding opportunity letter of intent due date: Lymphatics in Health and Disease in the Digestive System 

The purpose of this FOA is to invite applications that investigate aspects of lymphatic vessel physiology, development and pathophysiology related to health and diseases of the digestive system. Studies to understand the factors that control local lymphatic vessel functional anatomy and physiology and development during health or disease in this system and its organs, and the mechanisms by which alterations of lymphatic vessel function affect organ function, are of interest. However, studies with the major focus on immune mechanisms, role of lymphatics in cancer metastasis and study of lymphatic vessels in organs other than those from the digestive system will not be considered responsive. Application due date: Feb. 2, 2018.

More information: https://grants.nih.gov/grants/guide/rfa-files/RFA-DK-17-016.html


Jan. 9, 2018 

Funding Opportunity Letter of Intent Due Date: Vanderbilt Digestive Disease Research Center Pilot Project

The Pilot and Feasibility Project Program (P/F) is designed to provide Vanderbilt investigators the opportunity to explore nascent, meritorious hypotheses related to digestive diseases with the ultimate goal being acquisition of external funding. The Vanderbilt Digestive Disease Research Center (VDDRC) plans to fund pilot projects annually. Awards will be made for 1-2 years in duration.

More information: https://ww2.mc.vanderbilt.edu/ddrc/6938


Jan. 13, 2018 

Funding Opportunity Letter of Intent Due Date: George M. O'Brien Urology Cooperative Research Centers Program (U54Clinical Trial Optional) 

The purpose of this Funding Opportunity Announcement (FOA) is to seek applications for the George M. O’Brien Urology Cooperative Research Centers Program. This program will provide a coordinated platform for multidisciplinary interactions between basic and clinical scientists with the overall goal of understanding the etiology and development of benign urologic diseases and disorders, and providing a collaborative venue to design better treatments, diagnostics, and prevention strategies for these disease conditions within the NIDDK mission interests. This program will also serve as a national resource to the larger urological research community and provide educational enrichment opportunities to scientists electing to pursue research in benign urology. Accordingly, applications are sought from individuals willing to cooperate with the NIDDK under a cooperative centers program. The funded Centers will work with the NIDDK in facilitating research collaborations and interactions within and among centers and with the larger research community to accomplish the overall goal of improving treatment of urologic disorders through enhanced communication and research excellence.


Jan. 15, 2018 

Funding Opportunity Application Due Date: HIRN New Investigator Pilot Award 

The Human Islet Research Network (HIRN) is announcing a competitive New Investigator Pilot Award. The goal of this award is to support a small number of new investigators of exceptional creativity who propose to apply bold and highly innovative new research approaches to biological problems under current investigation in HIRN. The HIRN New Investigator Pilot Award is designed to provide support for early career investigators who may need funding to explore feasibility of a new concept in support of an eventual R01 application. The research proposed must be relevant to the goals of HIRN consortia. Contact the HIRN Coordinating Center (CC) at hirncc@coh.org.



Jan. 15, 2018 

Funding Opportunity Application Due Date: Vanderbilt Diabetes Center Discovery Program Grant 

An individual must be a member of the Vanderbilt or Meharry faculty (Instructor or above) and must fit within NIH Guidelines for eligibility. This P&F support is targeted to any investigator, new or established, proposing to utilize the VICB High-Throughput Screening Facility, BioVU, or the Vanderbilt Mass Spectrometry Research Center Cores to launch new research programs in drug, gene, or biomarker discovery related to diabetes, obesity, or the complications thereof. DRTC P&F grants are intended to provide support for studies that allow an investigator to develop preliminary data sufficient to prepare an application for independent research support through conventional granting mechanisms. This DRTC P&F grant mechanism is intended to support one year of research, although a second year of funding is possible through competitive application. Eligibility: An individual must be a member of the Vanderbilt or Meharry faculty (Instructor or above) and must fit within NIH Guidelines for eligibility.



Jan. 15, 2018 

Funding Opportunity Application Due Date: Vanderbilt Diabetes Research & Training Center Grant 

An individual must be a member of the Vanderbilt or Meharry faculty (Instructor or above) and must fit within NIH Guidelines for eligibility. P&F support is targeted to any investigator, who has not previously received at DRTC P&F award, new or established, from other fields willing to bring their research expertise to diabetes-relevant research, for investigators currently in the diabetes area whose proposed research would constitute a totally new direction, and for clinical and basic researchers who propose a joint research project. DRTC P&F grants are intended to provide support for studies that allow an investigator to develop preliminary data sufficient to prepare an application for independent research support through conventional granting mechanisms. An investigator is eligible for DRTC P&F support only once. Eligibility: An individual must be a member of the Vanderbilt or Meharry faculty (Instructor or above) and must fit within NIH Guidelines for eligibility.


Jan. 23, 2018 

Funding opportunity application due date: Diabetic Foot Consortium - Clinical Research Units (U01) 

This Funding Opportunity Announcement (FOA) invites applications for Clinical Research Units (CRUs) to form the new Diabetic Foot Consortium (DFC) for multi-site clinical research to validate biomarkers for diabetic foot ulcers that that can predict healing outcomes, guide treatment, and monitor healing and response to treatment. The long-term goal is to lay the foundation for a clinical trial network to test therapies that can improve healing and prevent amputations.



Jan. 25, 2018 

Funding opportunity application deadline: "Exploration of the Diabetic Foot Ulcer Niche" - Collaborative Pilot Program 

The purpose of this Pilot Program is to adapt and evaluate emerging techniques focused on defining cell types and subtypes and their three-dimensional context to the study of diabetic foot ulcers. This will be accomplished by funding pilot studies to conduct key establishing experiments that will be necessary to inform any future construction of an unbiased atlas of diabetic skin and foot ulcers. Pilot projects will be composed of multidisciplinary teams that consist of partnerships between: 1) clinical scientists with experience in diabetic foot ulcer biology and access to fresh human biopsies/surgical material for analysis, and 2) investigators with expertise in applying a diverse set of agnostic, medium- to high-throughput technologies with single cell-resolution to the systematic exploration of the cellular diversity of human tissues (e.g., CLARITY combined with highly multiplexed profiling of proteins and/or RNAs, imaging mass cytometry, etc.) or human tissue-derived cells (e.g., RNAseq, Dropseq, ATACseq, etc.).


Jan. 28, 2018 

Funding opportunity letter of intent due date: Developmental Centers for Interdisciplinary Research in Benign Urology (P20 - Clinical Trial Not Allowed) 

The purpose of this Funding Opportunity Announcement (FOA) is to seek applications for the Developmental Centers for Interdisciplinary Research in Benign Urology Program (P20). Among the goals of this Program is to further advance research in benign urology by building research teams and facilitating resources generation and sharing. The research teams should be composed of individuals with complementary expertise who propose to either develop innovative resources (Resource Development Projects) or a new research project (Scientific Research Projects) that utilize integrative approaches to address questions relevant to benign urological diseases or disorders. Patient-centered research is encouraged. Resources developed by the Resource Development Projects will be shared upon validation while resources developed within the Scientific Research Projects will be shared at the end or termination of the award, as appropriate and consistent with the program goal of further advancing research. Each Developmental Center is centered on a single Project and must contain an Administrative Core and an Educational Enrichment Program. As part of the efforts of the Division of Kidney, Urologic and Hematologic Diseases (DKUH) to expand and enhance benign urology research, the Developmental Centers Program will work in partnership with the George M. O'Brien Urology Cooperative Research Centers Program (U54) and the Multidisciplinary K12 Urologic Research (KURe) Career Development Program.




Jan. 30, 2018 

Funding opportunity application deadline: Harvard University Digestive Disease Center Pilot And Feasibility Program

The HDDC is focused on the study of epithelial cell function and mucosal biology in inflammation, host defense, and cancer of the gastrointestinal tract and related mucosal surfaces. Pilot & Feasibility projects will be considered for support if they relate directly or indirectly to this mission.



Jan. 31, 2018 

Diabetes Innovation Challenge Submission Deadline  

T1D Exchange and lead sponsors JDRF and The Helmsley Charitable Trust are pleased to announce the 2018 Diabetes Innovation Challenge. 2018 Diabetes Innovation Challenge is offering $250,000 in cash and in-kind Prizes to diabetes innovations!

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