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dkNET community events and announcements in March, 2017

Dear dkNET Community,

dkNET provides updates on activities of interest to the NIDDK-supported community. You could keep up to date on these activities through our Twitter feed @dkNET_info, through our Community Calendar, or through dkNET e-mail list. If you have an event or funding opportunities you'd like to advertise, please contact us info_at_dknet.org.


dkNET Updates 

  • Updates on Literature pages, including

    1. New Literature pages - more links are provided for publications
    2. Share the Literature page with friends in just one click
    3. Manage Literature - save Literature of interest for later 
                   Check out here for more information: https://dknet.org/about/blog/844



Events in March, 2017

Mar. 2, 2017

JAX Webinar: Designing & Optimizing mouse Breeding Schemes

Have you ever had to delay an experiment because you didn’t design your breeding scheme to produce enough knockout (KO) or control mice? Are you unsure of the most efficient way to set up your cross? Get a refresher on the fundamentals of basic mouse genetics and learn some tricks from our experts to plan your next experiment better. Join us for this seminar to learn:How to apply Mendelian genetics to mouse crosses? How to use Punnett squares to calculate expected genotypes? Ways to design efficient breeding schemes to create simple and complex genetic models that combine two or more alleles.

More information: https://www.jax.org/education-and-learning/education-calendar/webinars/2017/032017/breeding-schemes-mar-


Mar. 3, 2017

The BD2K Guide to the Fundamentals of Data Science Series: Algorithms & Optimization

Speaker: Pavel Pevzner, University of California San Diego

More information: http://www.bigdatau.org/data-science-seminars


Mar. 7-10, 2017

2017 HIRN Annual Investigator Meeting

dkNET team will attend 2017 HIRN Annual Meeting. If you plan to attend HIRN meeting, come meet us at the dkNET information booth to learn more about what dkNET can help you with your research!

Location: Bethesda, MD, USA

More information: https://hirnetwork.org


Mar. 9, 2017

JAX webinar: Key Differences Among B6 Substrains and the Research Impact

The C57BL/6 inbred mouse (B6) is the most commonly used research strain. This strain is the most well characterized, the first to have its entire genome sequenced, and the genetic background strain of choice for most targeted mutations and transgenics. The universal acceptance and demand for B6 mice has necessitated their production from multiple sources, introducing genetic and phenotypic variability that has important consequences for accurately interpreting and repeating research results. In this webinar, we will discuss the following topics: (1)A brief historical perspective on the development of B6 inbred mice and different substrains (2)Recent publications highlighting significant physiological and behavioral differences among different B6 inbred mice (3)The significance for control selection and experimental design (4)Key tips for avoiding common B6 research mistakes.

More information: https://www.jax.org/education-and-learning/education-calendar/webinars/2017/032017/b6-substrains-mar-9


Mar. 10, 2017

The BD2K Guide to the Fundamentals of Data Science Series: Bayesian Inference

Speaker: Mike Newton, California State University, Sacramento

More information: http://www.bigdatau.org/data-science-seminars


Mar. 17, 2017

The BD2K Guide to the Fundamentals of Data Science Series: Data Issues: Multiple testing, Bias, Confounding & Missing Data

Speaker: Lance Waller, Emory University

More information: http://www.bigdatau.org/data-science-seminars


Mar. 21, 2017

JAX webinar: Cre-lox Basics - Generating Knockout Mice 

Cre-lox technology has quickly become one of the most widely used and versatile tools for genetically engineering mice for human disease modeling. Join us as we introduce you to the principles of the technology, discuss basic research applications and demonstrate how to access the world’s largest collection of Cre-lox strains. In this seminar, you will learn about the following topics:(1)How Cre-lox overcomes the limitations of traditional knockout modeling technology (2) Breeding strategies to create traditional, tissue-specific, and inducible knockouts (3) Tips for navigating the world’s largest repository of Cre-lox strains.

More information: https://www.jax.org/education-and-learning/education-calendar/webinars/2017/032017/cre-lox-mar-21


Mar. 24, 2017

The BD2K Guide to the Fundamentals of Data Science Series: Causal Inference

Speaker: Joe Hogan, Brown University

More information: http://www.bigdatau.org/data-science-seminars


Mar. 28-31, 2017

17th Annual Levine-Riggs Diabetes Research Symposium

Location: Orlando, FL, USA

More information: http://www.cityofhope.org/research/medical-and-research-events-calendar/levine-symposium


Mar. 31, 2017

The BD2K Guide to the Fundamentals of Data Science Series: Data Visualization Tools & Communication

Speaker: Nils Gehlenborg, Harvard University

More information: http://www.bigdatau.org/data-science-seminars


Funding opportunities information and deadlines in March, 2017

Mar. 1, 2017 

JDRF Funding Application Due Date: Novel Bioengineered Materials and Device Concepts to Facilitate Development of Encapsulation Systems for Type 1 Diabetes 

JDRF is committed to accelerating the development of a beta cell replacement therapy with a replenishable source of insulin-producing cells capable of reversing hypoglycemia unawareness, restoring glucose control, and improving the management of insulin treatment in type 1 diabetes (T1D) without chronic systemic immunosuppression. To accomplish this goal, JDRF invites applications to define encapsulation systems and advance preclinical or clinical proof of concept studies aimed at validating beta cell replacement approaches for individuals living with T1D.

More information: http://grantcenter.jdrf.org/wp-content/uploads/2016/12/Novel-encapsulation-systems_FY17_RFA.pdf


Mar. 1, 2017 

JDRF Funding Application Due Date: The Role of the Microbiome in Type 1 Diabetes

JDRF is soliciting applications to investigate the role of the microbiome in type 1 diabetes (T1D). JDRF is committed to and most interested in proposals that focus on research that provide insights into developing safe approaches to augment, accelerate, or induce robust microbiome-induced immunoregulation in childhood.

More information: http://grantcenter.jdrf.org/rfa/the-role-of-the-microbiome-in-type-1-diabetes/


Mar. 3, 2017 

Letter of Intent Due Date: Stimulating Peripheral Activity to Relieve Conditions (SPARC): Foundational Peripheral Neuroanatomy and Functional Neurobiology in Under-Studied Organs (U01)

This NIH Funding Opportunity Announcement (FOA) is part of the Stimulating Peripheral Activity to Relieve Conditions (SPARC) Common Fund program. This FOA solicits applications for support of research to gather critical data and answer critical questions on functional peripheral neuroanatomy of organs and reveal the organ function controlled by neural circuits. Organs of interest include those where the peripheral neuroanatomy and functional neurobiology of the organ have been understudied, and which are not the subject of existing SPARC funding under RFA-RM-15-018.

More information:  https://grants.nih.gov/grants/guide/rfa-files/RFA-RM-17-003.html


Mar. 6, 2017 

Funding Opportunity Application Due Date: Vanderbilt Digestive Disease Research Center Pilot Project

The Pilot and Feasibility Project Program (P/F) is designed to provide Vanderbilt investigators the opportunity to explore nascent, meritorious hypotheses related to digestive diseases with the ultimate goal being acquisition of external funding. The Vanderbilt Digestive Disease Research Center (VDDRC) plans to fund pilot projects annually. Awards will be made for 1-2 years in duration.

More information: https://ww2.mc.vanderbilt.edu/ddrc/6938


Mar. 10, 2017 

Funding Opportunity Application Due Date: DiaComp Collaborative Funding Program: Diabetic Foot Ulcers – Planning Activities for Clinical Biomarker Studies

The purpose of this program is to support planning activities for the development of a multi-center study for clinical biomarkers and outcome measures for diabetic foot ulcers. It is also part of an effort by the NIDDK to support clinical studies that involve two or more institutions to build a collaborative framework for ongoing research on diabetic wound healing. Applications should propose a future clinical study based on the criteria listed below. The application should include a rationale for the future clinical study, documenting significance and need, and describe the potential impact of the clinical study on biomarkers and research infrastructure. Preliminary results and background to support the study and an overview of the study design should be provided. The latter should include an estimate of the number of subjects, entry criteria, and outcome measures. In addition, the application should describe the planning activities proposed to be conducted during the single year of this program. These may include meetings to develop the protocol, focus groups for the patient-centered outcomes, clinical studies to obtain preliminary data, quality control testing of patient sample analysis, biostatistical analysis to develop sample size calculations, or analysis of databases to inform recruitment strategies. The goal of the planning activities is to develop a complete study protocol for the validation of a biomarker or outcome measure for diabetic foot ulcers.

More information: https://www.diacomp.org/shared/collaborative.aspx


Mar. 16, 2017 

Funding Opportunity Application Due Date: Michigan Regional Comprehensive Metabolomics Resource Core Pilot And Feasibility Projects

This program is intended to provide opportunities for investigators to advance basic, clinical and translational biomedical science by incorporating metabolomic technologies into their research program. The goal of this program is to enable investigators to generate a sufficient body of preliminary information for a successful application for major research funding from NIH or other national granting agencies.

More information: http://mrc2.umich.edu/node/96


Mar. 16, 2017 

Funding Opportunity Application Due Date: Southeast Center For Integrated Metabolomics Pilot And Feasibility Projects

SECIM is now seeking proposals for 12-month pilot projects in metabolomics. The goal of this initiative is to enhance metabolomics research by providing support for investigators new to the field, developing new teams and partnerships, and investing in high-risk/high-impact research.

More information: http://secim.ufl.edu/pilot-funding/


Mar. 16, 2017 

Funding Opportunity Application Due Date: West Coast Metabolomics Center - Pilot And Feasibility Projects

The WCMC provides extensive services for metabolomics research. The goal of the Pilot and Feasibility Program is to enhance metabolomics research crucial to translational projects by providing support for investigators new to the metabolomics field, the development of new teams and partnerships, projects that link genomics, proteomics and metabolomics, and high risk/high impact research. The Pilot and Feasibility Program aims to form new multidisciplinary collaborations that will enhance the integration of new techniques that benefit multiple investigators. Potential applicants are encouraged to link basic, translational, and clinical researchers. Extending the collaborative nature of research projects by matching funds from other mechanisms is encouraged.

More information: http://metabolomics.ucdavis.edu/pilot-and-feasibility-projects-1


Mar. 17, 2017 

Funding Opportunity Application Due Date: Mayo Clinic Metabolomics Resource Pilot Projects And Feasibility Projects

The goal of the Pilot and Feasibility Program is to enhance metabolomics research crucial to translational projects by providing investigators who are new to the metabolomics field the opportunity to explore the use of metabolomics in their research and support high-risk and high-impact research.The Mayo Clinic Metabolomics Resource Core Pilot and Feasibility Program aims to form new multidisciplinary collaborations that will enhance the integration of the techniques offered at Mayo Clinic and benefit multiple investigators. Potential applicants are encouraged to link basic, translational and clinical research. Extending the collaborative nature of research projects with funds from other mechanisms is encouraged.

More information: http://www.mayo.edu/research/centers-programs/metabolomics-resource-core/pilot-feasibility-grants/pilot-feasibility-grants


Mar. 22, 2017 

Funding Opportunity Application Due Date: Therapeutic Targeting of The Human Islet Environment (UC4)

This Funding Opportunity Announcement (FOA) solicits applications for projects to develop strategies to target the human pancreatic environment in-vivo to deliver cell-based therapeutics, regulatory molecules or gene constructs that can protect or replenish the functional beta cell mass, or to develop synthetic sentinel biomarkers to safely monitor beta cell stress or disease initiation prior to the appearance of autoantibodies in individuals at risk of developing Type 1 Diabetes (T1D). Successful applicants will join the Consortium on Targeting and Regeneration (CTAR) that supports the development of innovative strategies to increase functional human beta cell mass in vivo through the controlled manipulation of beta cell replication, islet cell plasticity, or the reprogramming of pancreatic non-beta cells into beta-like cells. CTAR is part of the Human Islet Research Network (HIRN).

More information: https://grants.nih.gov/grants/guide/rfa-files/RFA-DK-17-003.html


Mar. 23, 2017 

Funding Opportunity Application Due Date: Competitive Collaborative Projects for Human Islet Biology (UC4) 

This Funding Opportunity Announcement solicits applications for collaborative research projects that will enhance the goals of the Human Islet Research Network (HIRN; www.hirnetwork.org). The HIRN is a collaborative program consisting of multiple related but distinct research consortia focused around two common goals: increasing our understanding of how human beta cells are lost in Type 1 Diabetes (T1D), and finding innovative strategies to protect or replace functional beta cell mass in diabetic patients. Applicants to this FOA will be expected to lend unique perspectives and novel approaches to the network, and will be expected to pursue experiments that will be consistent with HIRN's continuing emphasis on studies that elucidate key aspects of human biology and physiology.

More information: https://grants.nih.gov/grants/guide/rfa-files/RFA-DK-17-004.html


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