Curator Dashboard

Core provides infrastructure, disease modelling and compound screening expertise, to facilitate translation of basic scientific discoveries into tangible hit drug candidates. Platform acts as interface between fundamental biomedical research and high-standard drug discovery.

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• SciCrunch
• 1 week ago - submitted by Bruno F.R. Santos

Software Python package for analysis and visualization of spatial transcriptomics data. Framework to spatially and quantitatively profile the cellular neighborhood organized iTME.

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• RRID
• 1 week ago - submitted by Nancy Liu

Collection of spatial transcriptomics data of mouse CT26 sample generated by stereo-seq technology.

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• RRID
• 1 week ago - submitted by Nancy Liu

Software Python tool for detection of m6A from direct RNA-Seq data. Leverages multiple instance learning framework to detect m6a modifications from Nanopore Direct RNA Sequencing data.

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• dkNET
• 1 week ago - submitted by Shuai C

Software tool for long read based human genomic structural variation detection. Collects signatures of various types of SVs and employs clustering-and-refinement method to analyze signatures to implement sensitive SV detection.cuteSV2 is upgraded version of cuteSV.

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• dkNET
• 1 week ago - submitted by Shuai C

Software tool to fix base errors SNV/Indel in genome generated by noisy reads. Used to correct error bases in reference genome.

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• dkNET
• 1 week ago - submitted by Shuai C

Core facility within Lineberger Comprehensive Cancer Center that performs sample processing for the molecular, pathologic, and genomic characterization of patient-derived specimens using high-end instrumentation and state-of-the-art methods. Service offerings include nucleic acid extraction, gene expression profiling, spatial genomics, next-generation sequencing library preparation, and high-throughput sequencing. Protocols leverage the reproducibility and reliability of automated instrumentation to minimize batch effects and processing errors (e.g. sample swaps). These workflows have been continuously optimized over the last decade, with a sample-to-answer historic success rate of ~90% for the >15,000 FFPE samples TGL has processed.

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• SciCrunch
• 1 week ago - submitted by Edyta Vieth

Core provides collection of obstetric biological materials from prenatal visits through delivery along with annotated clinical information. In addition to specimen access, MOMI staff can provide study design assistance as needed.

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• SciCrunch
• 1 week ago - submitted by Edyta Vieth

Pitt Biospecimen Core provides human sample procurement in multiple UPMC hospitals across Pittsburgh. Standard operating procedures for procurement and processing are developed for each project in partnership with each study's principal investigator. A rigorous quality assurance program ensures SOP compliance. In addition to specimen banking and pathology consultation, research histology services by expert histology specialists are also available.

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• SciCrunch
• 2 weeks ago - submitted by Edyta Vieth

Bioinformatics Core Facility at the John G. Rangos Sr. Research Center provides bioinformatics as well as biostatistics services across a wide range of disease domains. The next-generation sequencing data analysis includes, but is not limited to, whole genome-, whole exome-, bulk and single cell epigenome-, bulk and single cell transcriptome, spatial transcriptome, microbiome, metabolome, proteome and lipidome data analysis. The facility specializes in T-, and B- cell repertoire data analysis, multi-omics initiatives, and multimodal analysis. Shiny dashboard and other web application development is also supported.

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• SciCrunch
• 2 weeks ago - submitted by Edyta Vieth

Provides expertise and research infrastructure across four key Cores of Biostatistics, Data Management and Information Systems, Qualitative Analysis, and Data Coordination.

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• SciCrunch
• 2 weeks ago - submitted by Edyta Vieth

Health Sciences Research Data Center is HIPAA compliant secure computing environment where study teams can store data and do analytics from anywhere with internet access. Teams work in Windows virtual desktop with memory, storage, and computing power dedicated to each user. Knowledgeable facility staff can provide data management, help with regulatory documents like DUAs, maintain systems compliance, and custom application development.

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• SciCrunch
• 2 weeks ago - submitted by Edyta Vieth

Small Animal Ultrasonogrphy Core provides high frequency ultrasound for non-invasive, in vivo, real-time, high-resolution imaging of tissue structure and function in small animals.

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• SciCrunch
• 2 weeks ago - submitted by Edyta Vieth

Core provides Instrument Services for analysis of 1) endogenous metabolic pathway intermediates or biomarkers from biological fluids, cell cultures, and tissues using Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS), 2) energy metabolism (cell bioenergetics) in living cells using a Seahorse Analyzer, and 3) biomarkers/metabolites to quantitate pathway intermediates using HPLC with 3 detector options (ECD, UV-VIS, FLR).

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• SciCrunch
• 2 weeks ago - submitted by Edyta Vieth

Flow Cytometry Core at John G. Rangos Sr. Research Center is a BSL2+ compliant cytometry analysis and sorting facility located at the John G. Rangos Sr. Research Center in Lawrenceville serving investigators from across the University of Pittsburgh.

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• SciCrunch
• 2 weeks ago - submitted by Edyta Vieth

Health Sciences Mass Spectrometry Core provides liquid chromatography high resolution mass spectrometry (LC-HRMS) services for metabolomics, lipidomics and proteomics. Expert staff provide assistance throughout the full lifespan of all projects from experimental design and sample preparation through statistical analysis and interpretation of datasets.

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• SciCrunch
• 2 weeks ago - submitted by Edyta Vieth

Drosophila Facility specializes in producing drosophila media in bulk and making it available to local investigators.

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• SciCrunch
• 2 weeks ago - submitted by Edyta Vieth

Gnotobiotic Animal Core Laboratory is a BSL2-compliant mouse facility providing isolators for studies requiring a controlled microbiotic environment. All husbandry and upkeep services are provided. Additional specialized support is also available.

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• SciCrunch
• 2 weeks ago - submitted by Edyta Vieth

Core offers services for custom synthesis and characterization of peptides, peptoids and small molecule constructs. The facility has extensive capabilities for technologically advanced custom modifications such as bioconjugations and targeted therapeutic strategies. State of the art HPLC and mass spectrometry capabilities as well as services in support of protein, siRNA, antibody and small molecule quantification and characterization are available

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• SciCrunch
• 2 weeks ago - submitted by Edyta Vieth

Small Biomarker Core provides accurate and sensitive quantitative analysis in biological samples, with or without sample processing, using state-of-the-art ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). In addition to well qualified assays for common targets, experienced, knowledgeable personnel can provide assay development for novel targets

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• SciCrunch
• 2 weeks ago - submitted by Edyta Vieth