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StRAnGER

StRAnGER (Statistical Ranking of ANotated Genomic Experimental Results) is a web application for the automated statistical analysis of annotated gene profiling experiments, exploiting controlled biological vocabularies, like the Gene Ontology or the KEGG pathways terms. Starting from annotated lists of differentially expressed genes StRAnGER repartitions and reorders the initial distribution of terms to define a new distribution of elements where each element pools terms holding the same enrichment score. The elements are then prioritized according to StRAnGER's algorithm and, by applying bootstrapping techniques, a corrected measure of the statistical significance of these elements is derived, enabling the selection of terms mapped to these elements, unambiguously associated with respective significant gene sets. Besides their high statistical score, another selection criterion for the terms is the number of their members, something that incurs a biological prioritization in line with a Systems Biology context. Platform: Online tool

URL: http://www.grissom.gr/stranger/

Resource ID: nlx_25932     Resource Type: Resource     Version: Latest Version

Keywords

controlled vocabulary, functional analysis, genomics, annotation, visualization, statistical analysis, term enrichment, ontology or annotation visualization

Comment

GO data updates: monthly (or more frequently)

Additional Resource Types

data analysis software

Availability

Free for academic use

Publication Link

http://www.ncbi.nlm.nih.gov/pubmed/21293737

Related To

Resource:GO

Abbreviation

StRAnGER

Parent Organization

Resource PubMed IDs

PMID: 21293737, PMID: 24158494

Resource Status

Last checked up;

Synonyms

Statistical Ranking of ANotated Genomic Experimental Results

Curation Status

curated

Listed By

Gene Ontology Tools

Supercategory

Resource

Original Submitter

Anonymous

Version Status

Curated

Submitted On

12:00am February 11, 2011

Originated From

SciCrunch

Changes from Previous Version

First Version

Version 1

Created 4 years ago by Anonymous