X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

StRAnGER

StRAnGER (Statistical Ranking of ANotated Genomic Experimental Results) is a web application for the automated statistical analysis of annotated gene profiling experiments, exploiting controlled biological vocabularies, like the Gene Ontology or the KEGG pathways terms. Starting from annotated lists of differentially expressed genes StRAnGER repartitions and reorders the initial distribution of terms to define a new distribution of elements where each element pools terms holding the same enrichment score. The elements are then prioritized according to StRAnGER's algorithm and, by applying bootstrapping techniques, a corrected measure of the statistical significance of these elements is derived, enabling the selection of terms mapped to these elements, unambiguously associated with respective significant gene sets. Besides their high statistical score, another selection criterion for the terms is the number of their members, something that incurs a biological prioritization in line with a Systems Biology context. Platform: Online tool

URL: http://www.grissom.gr/stranger/

Resource ID: nlx_25932     Resource Type: Resource     Version: Latest Version

Keywords

controlled vocabulary, functional analysis, genomics, annotation, visualization, statistical analysis, term enrichment, ontology or annotation visualization

Comment

GO data updates: monthly (or more frequently)

Listed By

Gene Ontology Tools

Supercategory

Resource

Related To

Resource:GO

Abbreviation

StRAnGER

Parent Organization

Synonyms

Statistical Ranking of ANotated Genomic Experimental Results

Additional Resource Types

data analysis software

Availability

Free for academic use

Publication Link

http://www.ncbi.nlm.nih.gov/pubmed/21293737

Original Submitter

Anonymous

Version Status

Curated

Submitted On

12:00am February 11, 2011

Originated From

SciCrunch

Changes from Previous Version

First Version

Version 1

Created 4 years ago by Anonymous

Exploiting Statistical Methodologies and Controlled Vocabularies for Prioritized Functional Analysis of Genomic Experiments: the StRAnGER Web Application.

  • Chatziioannou AA
  • Front Neurosci
  • 2011 4

StRAnGER is a web application for the automated statistical analysis of annotated gene profiling experiments, exploiting controlled biological vocabularies, like the Gene Ontology or the KEGG pathways terms. Starting from annotated lists of differentially expressed genes and gene enrichment scores, regarding the terms of each vocabulary, StRAnGER repartitions and reorders the initial distribution of terms to define a new distribution of elements. Each element pools terms holding the same enrichment score. The new distribution thus derived, is reordered in a decreasing order to the right, according to the observation score of the elements, while elements with the same score, are sorted again in a decreasing order of their enrichment scores. By applying bootstrapping techniques, a corrected measure of the statistical significance of these elements is derived, which enables the selection of terms mapped to these elements, unambiguously associated with respective significant gene sets. The selected terms are immunized against the bias infiltrating statistical enrichment analyses, producing technically very high statistical scores, due to the finite nature of the data population. Besides their high statistical score, another selection criterion for the terms is the number of their members, something that incurs a biological prioritization in line with a Systems Biology context. The output derived, represents a detailed ranked list of significant terms, which constitute a starting point for further functional analysis.