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Retina Project

Images from cell type-specific protein expression in the retina using BAC transgenic mice from the GENSAT project. They carried out a screen for cell type-specific green fluorescent protein expression in the retina using BAC transgenic mice from the GENSAT project. Among others, mouse lines were identified in which the inhibitory cell types of the night vision and directional selective circuit were selectively labeled. They quantified the stratification patterns to predict potential synaptic connectivity between marked cells of different lines and found that some of the lines enabled targeted recordings and imaging of cell types from developing or mature retinal circuits. The results suggest the potential use of a stratification-based screening approach for characterizing neuronal circuitry in other layered brain structures, such as the neocortex.

URL: http://www.gensat.org/retina.jsp

Resource ID: nif-0000-25587     Resource Type: Resource     Version: Latest Version

Keywords

electrophysiology, protein expression, fluorescent, gene, amacrine cell, astrocyte, bipolar cell, blood vessel, brain, cell, ganglion cell layer, central nervous system, circuit, horizontal cell, hybridization, microglia, adult mouse, muller cell, neocortex, neuronal, photoreceptor, protein, recombinase, retina, spinal cord, mutant mouse strain, bac, retinal cell, cell type, night vision, direction, neuronal circuitry, connectivity, image collection

Additional Resource Types

spatially referenced dataset

Availability

Public, Acknowledgement requested

Supercategory

Resource

Abbreviation

Retina Project

Synonyms

The Retina Project, GENSAT - Retina Project, GENSAT Retina Project, Retina Project from GENSAT, The Retina Project from GENSAT

Parent Organization

Funding Information

Friedrich Miescher Institute, US Office of Naval Research, Naval International Cooperative Opportunities in Science and Technology Program, Marie Curie Excellence, National Center for Competence in Research in Genetics, European Union, NINDS, HEALTH-F2-223156, contract N01NS02331, contract HHSN271200723701C

Used By

NIF Data Federation

Species

mouse

Original Submitter

Anonymous

Version Status

Curated

Submitted On

12:00am April 24, 2012

Originated From

SciCrunch

Changes from Previous Version

First Version

Version 1

Created 3 years ago by Anonymous