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NIH Clinical Collection

A plated array of approximately 450 small molecules that have a history of use in human clinical trials. The collection was assembled by the National Institutes of Health (NIH) through the Molecular Libraries Roadmap Initiative as part of its mission to enable the use of compound screens in biomedical research. Similar collections of FDA approved drugs have proven to be rich sources of undiscovered bioactivity and therapeutic potential. The clinically tested compounds in the NCC are highly drug-like with known safety profiles. These compounds can provide excellent starting points for medicinal chemistry optimization and, for high-affinity targets, may even be appropriate for direct human use in new disease areas.

URL: http://www.nihclinicalcollection.com

Resource ID: nif-0000-00254     Resource Type: Resource     Version: Latest Version


clinical, collection, drug, compound, chemistry, medicinal chemistry, target, affinity, human, disease, disorder, small molecule

Related To

Molecular Libraries Program



Funding Information


Additional Resource Types

Reagent Supplier, Material Resource



Parent Organization

Original Submitter


Version Status


Submitted On

12:00am September 21, 2010

Originated From


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    Version 4

    Created 1 month ago by Christie Wang

    Version 3

    Created 1 month ago by Christie Wang

    Version 2

    Created 1 month ago by Christie Wang

    Version 1

    Created 5 years ago by Anonymous