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NCBI Sequence Read Archive

Repository of raw sequencing data from the next generation of sequencing platforms including including Roche 454 GS System, Illumina Genome Analyzer, Applied Biosystems SOLiD System, Helicos Heliscope, Complete Genomics, and Pacific Biosciences SMRT. In addition to raw sequence data, SRA now stores alignment information in the form of read placements on a reference sequence. Data submissions are welcome. SRA is NIH''''s primary archive of high-throughput sequencing data and is part of the international partnership of archives (INSDC) at the NCBI, the European Bioinformatics Institute and the DNA Database of Japan. Data submitted to any of the three organizations are shared among them. NCBI announced that due to budget constraints, it would be discontinuing SRA but NIH has since committed interim funding for SRA in its current form until October 1, 2011. In addition, NCBI has been working with staff from other NIH Institutes and NIH grantees to develop an approach to continue archiving a widely used subset of next generation sequencing data after October 1, 2011.

URL: http://www.ncbi.nlm.nih.gov/sra

Resource ID: nlx_86174     Resource Type: Resource     Version: Latest Version

Keywords

sequence, blast, next-generation sequence, alignment, read placement, reference sequence, roche 454 gs system, illumina genome analyzer, applied biosystems solid system, helicos heliscope, complete genomics, pacific biosciences smrt, high-throughput sequencing, data analysis service, gold standard

Funding Information

NLM,

Listed By

OMICtools

Alternate IDs

OMICS_01031

Related To

European Nucleotide Archive, DDBJ Sequence Read Archive, Monarch Initiative

Abbreviation

SRA

Parent Organization

Synonyms

Sequence Read Archive, NCBI SRA

Additional Resource Types

Database, Data Repository

Availability

Public, The community can contribute to this resource

Supercategory

Resource

Original Submitter

Anonymous

Version Status

Curated

Submitted On

12:00am June 10, 2011

Originated From

SciCrunch

Changes from Previous Version

    No Changes

    Version 4

    Created 2 weeks ago by Christie Wang

    Version 3

    Created 3 weeks ago by Christie Wang

    Version 2

    Created 3 weeks ago by Christie Wang

    Version 1

    Created 4 years ago by Anonymous

    The Sequence Read Archive: explosive growth of sequencing data.

    • Kodama Y
    • Nucleic Acids Res.
    • 2012 23

    New generation sequencing platforms are producing data with significantly higher throughput and lower cost. A portion of this capacity is devoted to individual and community scientific projects. As these projects reach publication, raw sequencing datasets are submitted into the primary next-generation sequence data archive, the Sequence Read Archive (SRA). Archiving experimental data is the key to the progress of reproducible science. The SRA was established as a public repository for next-generation sequence data as a part of the International Nucleotide Sequence Database Collaboration (INSDC). INSDC is composed of the National Center for Biotechnology Information (NCBI), the European Bioinformatics Institute (EBI) and the DNA Data Bank of Japan (DDBJ). The SRA is accessible at www.ncbi.nlm.nih.gov/sra from NCBI, at www.ebi.ac.uk/ena from EBI and at trace.ddbj.nig.ac.jp from DDBJ. In this article, we present the content and structure of the SRA and report on updated metadata structures, submission file formats and supported sequencing platforms. We also briefly outline our various responses to the challenge of explosive data growth.

    The sequence read archive.

    • Leinonen R
    • Nucleic Acids Res.
    • 2011 23

    The combination of significantly lower cost and increased speed of sequencing has resulted in an explosive growth of data submitted into the primary next-generation sequence data archive, the Sequence Read Archive (SRA). The preservation of experimental data is an important part of the scientific record, and increasing numbers of journals and funding agencies require that next-generation sequence data are deposited into the SRA. The SRA was established as a public repository for the next-generation sequence data and is operated by the International Nucleotide Sequence Database Collaboration (INSDC). INSDC partners include the National Center for Biotechnology Information (NCBI), the European Bioinformatics Institute (EBI) and the DNA Data Bank of Japan (DDBJ). The SRA is accessible at http://www.ncbi.nlm.nih.gov/Traces/sra from NCBI, at http://www.ebi.ac.uk/ena from EBI and at http://trace.ddbj.nig.ac.jp from DDBJ. In this article, we present the content and structure of the SRA, detail our support for sequencing platforms and provide recommended data submission levels and formats. We also briefly outline our response to the challenge of data growth.