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Mouse Mutagenesis Center for Developmental Defects

THIS RESOURCE IS NO LONGER IN SERVICE. For updated mutant information, please visit MMRRC or The Jackson Laboratory. Produces, characterizes, and distributes mutant mouse strains with defects in embryonic and postembryonic development. The goal of the ENU Mutagenesis project III is to determine the function of genes on mouse Chromosome 11 by saturating the chromosome with recessive mutations. The distal 40 cM of mouse Chr 11 exhibits linkage conservation with human Chromosome 17. We are using the chemical N-ethyl-N-nitrosourea (ENU) to saturate wild type chromosomes with point mutations. By determining the function of genes on a mouse chromosome, we can extrapolate to predict function on a human chromosome. We expect many of the new mutants to represent models of human diseases such as birth defects, patterning defects, growth and endocrine defects, neurological anomalies, and blood defects. Because many of the mutations we expect to isolate may be lethal or detrimental to the mice, we are using a unique approach to isolate mutations. This approach uses a balancer chromosome that is homozygous lethal and carries a dominant coat color marker to suppress recombination over a reasonable interval.

URL: http://www.mouse-genome.bcm.tmc.edu/ENU/MutagenesisProj.asp

Resource ID: nif-0000-00190     Resource Type: Resource     Version: Latest Version

Keywords

mutant, embryo, post embryonic, mutagenesis, craniofacial, eye, fertility, growth, lethal, metabolism, neurological, skeletal, skin, coat, urogenital, cryopreserved, enu, defect, birth defect, , patterning defect, growth defect, endocrine defects, neurological anomaly, blood defect, mouse model, human disease, n-ethyl-n-nitrosourea, chromosome 11, phenotype

Funding Information

NICHD, NIGMS, NIA, NIAMS, NHLBI, NIDDK, NIDCR, NIH Blueprint for Neuroscience Research,

Listed By

One Mind Biospecimen Bank Listing, Biobank

Species

mouse

Related To

One Mind Biospecimen Bank Listing, Mutant Mouse Regional Resource Centers, Jackson Laboratory, dkNET,NIDDK Information Network

Abbreviation

Mouse Mutagenesis for Developmental Defects

Parent Organization

Synonyms

NIH Mouse Mutagenesis Center for Developmental Defects

Additional Resource Types

Organism Supplier, Biomaterial Manufacture

Related Disease

Aging

Supercategory

Resource

Original Submitter

Anonymous

Version Status

Curated

Submitted On

12:00am September 21, 2010

Originated From

SciCrunch

Changes from Previous Version

    No Changes

    Version 5

    Created 1 week ago by Christie Wang

    Version 4

    Created 2 weeks ago by Christie Wang

    Version 3

    Created 2 weeks ago by Christie Wang

    Version 2

    Created 2 months ago by Christie Wang

    Version 1

    Created 5 years ago by Anonymous