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Kawasaki Disease Dataset2

Dataset from an investigation of biochemical evidence of myocardial strain, oxidative stress, and cardiomyocyte injury in 55 acute KD subjects (30 with paired convalescent samples), 54 febrile control (FC), and 50 healthy control (HC) children by measuring concentrations of cardiovascular biomarkers. NT-proBNP and sST2 were elevated in acute KD subjects and correlated with impaired myocardial relaxation. These findings, combined with elevated levels of cTnI, suggest that both cardiomyocyte stress and cell death are associated with myocardial inflammation in acute KD.

URL: https://neuinfo.org/mynif/search.php?q=nlx_144644&t=indexable&list=cover&nif=nlx_144509-1

Resource ID: nlx_144644     Resource Type: Resource     Version: Latest Version

Keywords

kawasaki disease, nt-probnp, sst2, copeptin, ct-proet-1, mr-proadm, mr-proanp, pct, troponin i cardiac muscle, cardiovascular biomarker, cardiovascular, biomarker, child, acute, convalescent, febrile, ctni, myocardial inflammation, pediatric

Old URLs

http://neuinfo.org/nif/nifgwt.html?query=kawasaki&category=Data%20Type:Dataset

Species

human

Abbreviation

KD Data

Additional Resource Types

Data Set

Parent Organization

Used By

NIF Data Federation

Related Disease

Kawasaki disease, Normal

Supercategory

Resource

Original Submitter

Anonymous

Version Status

Curated

Submitted On

12:00am June 5, 2012

Originated From

SciCrunch

Changes from Previous Version

  • Description was changed
  • Additional Resource Types was changed

Version 2

Created 2 weeks ago by Christie Wang

Version 1

Created 3 years ago by Anonymous

Cardiovascular biomarkers in acute Kawasaki disease.

  • Sato YZ
  • Int. J. Cardiol.
  • 2013 20

BACKGROUND: Endomycocardial biopsies have demonstrated that subclinical myocarditis is a universal feature of acute Kawasaki disease (KD). METHODS: We investigated biochemical evidence of myocardial strain, oxidative stress, and cardiomyocyte injury in 55 acute KD subjects (30 with paired convalescent samples), 54 febrile control (FC), and 50 healthy control (HC) children by measuring concentrations of cardiovascular biomarkers. RESULTS: Levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and soluble ST2 (sST2) were elevated in acute vs. convalescent KD, FC, and HC (p≤0.002), while γ-glutamyl transferase and alanine amino transferase as measures of oxidative stress were increased in acute vs. FC (p≤0.0002). Cardiac troponin I (cTnI) levels, using a highly sensitive assay, were elevated in 30% and 40% of paired acute and convalescent KD subjects, respectively, and normalized within two years of disease onset. NT-proBNP and sST2 negatively correlated with deceleration time, but only NT-proBNP correlated with MV E:A ratio and internal diameter of the coronary arteries (RCA/LAD Zworst). CONCLUSIONS: NT-proBNP and sST2 were elevated in acute KD subjects and correlated with impaired myocardial relaxation. These findings, combined with elevated levels of cTnI, suggest that both cardiomyocyte stress and cell death are associated with myocardial inflammation in acute KD.