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IUPHAR Database

The IUPHAR database is an established online reference resource for several important classes of human drug targets and related proteins. As well as providing recommended nomenclature, the database integrates information on the chemical, genetic, functional and pathophysiological properties of receptors and ion channels, curated and peer-reviewed from the biomedical literature by a network of experts. The database incorporates detailed pharmacological, functional and pathophysiological information on G Protein-Coupled Receptors, Voltage-Gated Ion Channels, Ligand-Gated Ion Channels and Nuclear Hormone Receptors (NHRs). Data types for NHRs include details on co-regulators, DNA binding motifs, target genes and 3D structures. Recent developments include curation of the chemical structures of approximately 2000 ligand molecules, providing electronic descriptors, identifiers, link-outs and calculated molecular properties, all available via enhanced ligand pages. The interface provides intelligent tools for the visualization and exploration of ligand structure-activity relationships and the structural diversity of compounds active at each target. IUPHAR-DB contributors The IUPHAR database is developed under the auspices of NC-IUPHAR to provide an accurate educative resource to the scientific community. It relies on contributions by expert pharmacologists who volunteer their time. All contributors are attributed on the website, allowing receptor data pages to be properly cited. Annotation procedure NC-IUPHAR has a network of expert subcommittees (presently over 60), each responsible for developing the nomenclature for a receptor family and contributing data. Where no relevant subcommittee exists, data are captured by the curators or individual experts and peer reviewed by at least two external expert referees. The data The data are summarized from selected primary literature articles, which are linked to PubMed. Where possible the data are linked to other relevant databases for further information.

URL: http://www.iuphar-db.org

Resource ID: nif-0000-03056     Resource Type: Resource     Version: Latest Version

Keywords

human, rodent, gold standard

Abbreviation

IUPHAR-DB, IUPHAR GPCR, IUPHAR RECEPTOR

Synonyms

International Union of Pharmacology Database, International Union of Basic and Clinical Pharmacology Database

Funding Information

British Pharmacological Society, Abbott Laboratories, GlaxoSmithKline, Incyte, Millipore, Novartis, Servier, UNESCO, Wyeth,

Additional Resource Types

Database, International Standard Specification

Supercategory

Resource

Parent Organization

Original Submitter

Anonymous

Version Status

Curated

Submitted On

12:00am March 3, 2011

Originated From

SciCrunch

Changes from Previous Version

  • Description was changed
  • Funding Information was changed
  • Additional Resource Types was changed

Version 2

Created 3 weeks ago by Christie Wang

Version 1

Created 4 years ago by Anonymous

IUPHAR-DB: new receptors and tools for easy searching and visualization of pharmacological data.

  • Sharman JL
  • Nucleic Acids Res.
  • 2011 23

The IUPHAR database is an established online reference resource for several important classes of human drug targets and related proteins. As well as providing recommended nomenclature, the database integrates information on the chemical, genetic, functional and pathophysiological properties of receptors and ion channels, curated and peer-reviewed from the biomedical literature by a network of experts. The database now includes information on 616 gene products from four superfamilies in human and rodent model organisms: G protein-coupled receptors, voltage- and ligand-gated ion channels and, in a recent update, 49 nuclear hormone receptors (NHRs). New data types for NHRs include details on co-regulators, DNA binding motifs, target genes and 3D structures. Other recent developments include curation of the chemical structures of approximately 2000 ligand molecules, providing electronic descriptors, identifiers, link-outs and calculated molecular properties, all available via enhanced ligand pages. The interface now provides intelligent tools for the visualization and exploration of ligand structure-activity relationships and the structural diversity of compounds active at each target. The database is freely available at http://www.iuphar-db.org.