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DIAN - Dominantly Inherited Alzheimer Network

An international research partnership of leading scientists determined to understand a rare form of Alzheimer''''s disease that is caused by a gene mutation and to establish a research database and tissue repository to support research on Alzheimer''''s disease by other investigators around the world. Understanding of this form of Alzheimer''''s disease may provide clues to decoding other dementias and developing dementia treatments. DIAN is currently enrolling study participants who are biological adult children of a parent with a mutated gene known to cause dominantly inherited Alzheimer''''s disease. Such individuals may or may not carry the gene themselves and may or may not have disease symptoms. Research suggests that certain brain changes occur years before actual Alzheimer''''s symptoms are detected. One goal of DIAN is to study these possible changes in people who carry an Alzheimer''''s disease mutation. Other family members without a mutation will serve as a comparison group. People in families in which a mutation has been identified will be tracked in order to detect physical or mental changes that might distinguish people who inherited the mutation from those who did not. A list of procedures that participants may be involved in include: * Clinical assessment * Memory and thinking tests * Blood draw * Cerebral spinal fluid sample testing and banking * Brain magnetic resonance imaging (MRI) * Brain fluorodeoxyglucose positron emission tomography (FDG PET) * Brain positron emission tomography using Pittsburgh Compound-B (PET-PIB) * Brain autopsy in case of death Participants will have the procedures at the time of enrollment into DIAN and thereafter every one to three years, depending on the participant''''s age and the age at which his or her family member began to show signs of Alzheimer''''s disease. DIAN currently involves eleven outstanding research institutions in the United States, United Kingdom, and Australia. John C. Morris, M.D., Friedman Distinguished Professor of Neurology at Washington University School of Medicine in St. Louis, is the project''''s principal investigator.

URL: http://www.dian-info.org/default.htm

Resource ID: nlx_149316     Resource Type: Resource     Version: Latest Version

Keywords

gene mutation, dementia, cerebrum, image, middle frontal gyrus, superior temporal gyri, middle temporal gyri, inferior parietal lobe, angular gyrus, occipital lobe, calcarine sulcus, peristriate cortex, anterior cingulate gyrus, genu of the corpus callosum, posterior cingulate gyrus, precuneus, splenium, amygdala, entorhinal cortex, hippocampus, parahippocampal gyrus, striatum, caudate nucleus, anterior commissure, lentiform nuclei, globus pallidus, putamen, thalamus, subthalamic nucleus, midbrain, pons, medulla oblongata, cerebellum, dentate nucleus, spinal cord, frontal lobe, temporal lobe, mamillary body, parietal lobe, lateral geniculate nucleus, occipital lobe, calcarine sulcus, cerebellar hemisphere, dentate nucleus, clinical dementia rating, geriatric depression scale, functional assessment questionnaire, neuropsychiatric inventory-q, united parkinsons disease rating scale (updrs)-motor, hachinski ischemic score, cerebrovascular risk factor, cerebral spinal fluid, plasma, serum, blood, brain tissue, brain, tissue, formalin-fixed, paraffin wax embedded, block, frozen, clinical data, clinical, demographics, psychometrics, apoe genotype, adult human, mri, positron emission tomography, clinical assessment, psychometric testing

Funding Information

NIA, U01AG032438

Additional Resource Types

Disease-related Portal, Biomaterial Supply Resource, Brain Bank, Database

Availability

Approval required, DIAN data sharing policy

Related Disease

Dominantly inherited Alzheimer''''s disease, Biological adult child of a parent with a mutated gene known to cause dominantly inherited Alzheimer''''s disease, Alzheimer''''s disease, Normal control, Aging

Publication Link

http://www.dian-info.org/pdfs/Brochure.pdf

Related To

National Cell Repository for Alzheimers Disease

Abbreviation

DIAN

Parent Organization

Processing

Formalin-fixed, Paraffin wax embedded, Block, Frozen

Species

human

Synonyms

Dominantly Inherited Alzheimer Network, Dominantly Inherited Alzheimer Network (DIAN)

Comment

Sample type: Cerebral Spinal Fluid, Plasma, Serum, Blood, Brain tissue, Brain, Tissue

Listed By

One Mind Biospecimen Bank Listing, Biobank

Related Application

Research

Supercategory

Resource

Original Submitter

Anonymous

Version Status

Curated

Submitted On

12:00am July 19, 2012

Originated From

SciCrunch

Changes from Previous Version

    No Changes

    Version 4

    Created 1 week ago by Christie Wang

    Version 3

    Created 2 weeks ago by Christie Wang

    Version 2

    Created 2 weeks ago by Christie Wang

    Version 1

    Created 3 years ago by Anonymous