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Comparative Toxicogenomics Database

A public database that enhances understanding about the effects of environmental chemicals on human health. Integrated GO data and a GO browser add functionality to CTD by allowing users to understand biological functions, processes and cellular locations that are the targets of chemical exposures. CTD includes curated data describing cross-species chemical����??gene/protein interactions and chemical����?? and gene����??disease associations to illuminate molecular mechanisms underlying variable susceptibility and environmentally influenced diseases. These data will also provide insights into complex chemical����??gene and protein interaction networks. Use CTD to discover: # What human diseases are associated with a gene/protein? # What human diseases are associated with a chemical? # What genes/proteins interact with a chemical? # What chemicals interact with a gene/protein? # What references report a chemical����??gene/protein interaction? # What cellular functions (GO terms) are affected by a chemical?

URL: http://ctdbase.org/

Resource ID: nif-0000-02683     Resource Type: Resource     Version: Latest Version


environment, chemical, disease, gene, pathway, protein, interaction, animal model, ontology, annotation, toxin, ontology or annotation browser

Funding Information

Pfizer, American Chemistry Council, NCRR, NIEHS, ES014065, R01 ES019604, P20 RR016463

Listed By

3DVC, Gene Ontology Tools


Public, Free for academic use, Acknowledgement required

Alternate IDs


Related To

GO, OMICtools



Parent Organization

Related Application

Research, Education


human, mouse, rat, chicken, zebrafish, dog


CTD - Comparative Toxicogenomics Database

Additional Resource Types

Database, Data Analysis Service

Used By

NIF Data Federation, Monarch Initiative

Alternate URLs




Original Submitter


Version Status


Submitted On

12:00am October 19, 2010

Originated From


Changes from Previous Version

    No Changes

    Version 5

    Created 1 week ago by Christie Wang

    Version 4

    Created 2 weeks ago by Christie Wang

    Version 3

    Created 2 weeks ago by Christie Wang

    Version 2

    Created 2 months ago by Christie Wang

    Version 1

    Created 5 years ago by Anonymous

    The comparative toxicogenomics database: a cross-species resource for building chemical-gene interaction networks.

    • Mattingly CJ
    • Toxicol. Sci.
    • 2006 7

    Chemicals in the environment play a critical role in the etiology of many human diseases. Despite their prevalence, the molecular mechanisms of action and the effects of chemicals on susceptibility to disease are not well understood. To promote understanding of these mechanisms, the Comparative Toxicogenomics Database (CTD; http://ctd.mdibl.org/) presents scientifically reviewed and curated information on chemicals, relevant genes and proteins, and their interactions in vertebrates and invertebrates. CTD integrates sequence, reference, species, microarray, and general toxicology information to provide a unique centralized resource for toxicogenomic research. The database also provides visualization capabilities that enable cross-species comparisons of gene and protein sequences. These comparisons will facilitate understanding of structure-function correlations and the genetic basis of susceptibility. Manual curation and integration of cross-species chemical-gene and chemical-protein interactions from the literature are now underway. These data will provide information for building complex interaction networks. New CTD features include (1) cross-species gene, rather than sequence, query and visualization capabilities; (2) integrated cross-links to microarray data from chemicals, genes, and sequences in CTD; (3) a reference set related to chemical-gene and protein interactions identified by an information retrieval system; and (4) a "Chemicals in the News" initiative that provides links from CTD chemicals to environmental health articles from the popular press. Here we describe these new features and our novel cross-species curation of chemical-gene and chemical-protein interactions.

    The Comparative Toxicogenomics Database (CTD): a resource for comparative toxicological studies.

    • Mattingly CJ
    • J. Exp. Zoolog. Part A Comp. Exp. Biol.
    • 2006 1

    The etiology of most chronic diseases involves interactions between environmental factors and genes that modulate important biological processes (Olden and Wilson, 2000. Nat Rev Genet 1(2):149-153). We are developing the publicly available Comparative Toxicogenomics Database (CTD) to promote understanding about the effects of environmental chemicals on human health. CTD identifies interactions between chemicals and genes and facilitates cross-species comparative studies of these genes. The use of diverse animal models and cross-species comparative sequence studies has been critical for understanding basic physiological mechanisms and gene and protein functions. Similarly, these approaches will be valuable for exploring the molecular mechanisms of action of environmental chemicals and the genetic basis of differential susceptibility.

    The Comparative Toxicogenomics Database (CTD).

    • Mattingly CJ
    • Environ. Health Perspect.
    • 2003 22

    The Mount Desert Island Biological Laboratory in Salsbury Cove, Maine, USA, is developing the Comparative Toxicogenomics Database (CTD), a community-supported genomic resource devoted to genes and proteins of human toxicologic significance. CTD will be the first publicly available database to a) provide annotated associations among genes, proteins, references, and toxic agents, with a focus on annotating data from aquatic and mammalian organisms; b) include nucleotide and protein sequences from diverse species; c) offer a range of analysis tools for customized comparative studies; and d) provide information to investigators on available molecular reagents. This combination of features will facilitate cross-species comparisons of toxicologically significant genes and proteins. These comparisons will promote understanding of molecular evolution, the significance of conserved sequences, the genetic basis of variable sensitivity to environmental agents, and the complex interactions between the environment and human health. CTD is currently under development, and the planned scope and functions of the database are described herein. The intent of this report is to invite community participation in the development of CTD to ensure that it will be a valuable resource for environmental health, molecular biology, and toxicology research.