X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Cerebellar Gene Regulation in Time and Space Database

Time-series data sets spanning twelve time-points between E12-P9 for exploring cerebellar development of the mouse in time and space. The database contains a number of mutant / wildtype microarray datasets including two complete wildtype microarray time-series (C57BL/6 and DBA/2J). The dataset also includes in situ hybridization and bioinformatic analyses. Exploration of this dataset will allow the investigator to assess differential gene expression profiles from a developing mutant cerebella, to assess the temporal changes in gene expression in the wildtype, and to verify the cellular expression of these genes in images from our in situ hybridization library. Using the database, the investigator can explore the developmental expression or differential expression patterns of a particular gene, or create lists of similarly expression genes by building simple search algorithms. These lists can then be mined across all the datasets in both space and time. Cb GRiTS''s current datasets represent gene expression analyses from multiple cerebellar mutant and wildtype single time-point and developmental series: * C57BL/6 WT Time Series: A developmental time-series (E12, E13, E14, E15, E16, E17, E18, E19, P0, P3, P6, P9) from wildtype C57BL/6 mice. Run on Illumina v1.1 platforms. * DBA/2J WT Time Series; A developmental time-series (E12, E13, E14, E15, E16, E17, E18, P0, P3, P6, P9) from wildtype DBA/2J mice. Run on Illumina v1.1 platforms. * Math1 Mutant (E15.5): A single time-point (E15.5) from mutant and wildtype littermates carrying the Rhombic lip derivative gene, Math1. Run on an Affymetrix U74a_v2 and M430A&B platforms. * Meandertail Mutant: A single time-point (E15.5) from mutant and wildtype littermates carrying the presumed granule cell specific, Meandertail, gene mutation. Run on an Affymetrix M430v2.0 platform. * Pax6 Sey Mutant Time Series: A developmental time-series (E13.5, 15.5, 18.5) from mutant and wildtype littermates carrying the cerebellar granule cell specific gene, Pax6, gene null mutation. Run on an Affymetrix U74a_v2 platform. * Riken Mut/WT Time Series: A developmental time-series (E18.5, P7, P14, P21, P56) from wildtype C57BL/6 mice. Run on the Affymetrix MU11K platform. * Staggerer Mut/WT Time Series: A development time series (E15.5, E17.5, P0, P1, P4) from mutant and wildtype littermates carrying the Purkinje cell specific, RORa, knockout mutation. Run on an Affymetrix U74a_v2 platform. * Zic 1/4 Mut/WT Time Series

URL: http://www.cbgrits.org/

Resource ID: nif-0000-10192     Resource Type: Resource     Version: Latest Version

Keywords

anova, helmert analysis, polynomial analysis, differential equation modeling, paraclique analysis, parent/child analysis, microarray, mouse, mouse model, c57bl/6, dba/2j, in situ hybridization, bioinformatic analyses, gene expression, developmental expression, differential expression, development, cerebellum, phenotype, paraclique analysis, dynamic system modeling, prenatal, adult mouse, embryonic mouse, time series, gene

Additional Resource Types

Database

Species

mouse

Abbreviation

CbGRiTS Database, Cb GRiTS

Synonyms

Cb GRiTS Database, CbGRITS

Parent Organization

Funding Information

NIH, HD052472

Old URLs

http://grits.dglab.org/

Supercategory

Resource

Original Submitter

Anonymous

Version Status

Curated

Submitted On

12:00am September 21, 2010

Originated From

SciCrunch

Changes from Previous Version

  • Description was changed
  • Additional Resource Types was changed

Version 2

Created 3 weeks ago by Christie Wang

Version 1

Created 5 years ago by Anonymous