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BrainPeps

Database of blood-brain barrier properties of peptides including structure, method, responses, physicochemical properties and related literature. The database is linked to a manuscript entitled Brainpeps: the blood-brain barrier peptide database, in which the BBB methods and responses are clarified and correlated to each other. Data may be submitted for addition to the database.

URL: http://brainpeps.ugent.be/

Resource ID: nlx_149082     Resource Type: Resource     Version: Latest Version

Keywords

peptide, intravenous injection, efflux study, immortal cell line, brain slice, ultracentrifugation, bui method, capillary depletion, iam-hplc, indicator diffusion, bmec, shake flask, non-cerebral cell line, in vitro equilibrium dialysis, microdialysis, imaging techniques, quantitative autoradiography, antinociception, hplc, in situ brain perfusion, (co)-culture, mbua, ultrafiltration, cisternal puncture, bei method, gibbs adsorption isotherm, pampa, blood-brain barrier, brain, permeability, distribution, data set

Additional Resource Types

database, data repository

Availability

Acknowledgement requested, The community can contribute to this resource

Abbreviation

Brainpeps

Synonyms

Brain Peps

Parent Organization

Funding Information

Institute for the Promotion of Innovation through Science and Technology in Flanders IWT-Vlaanderen, 73402

Listed By

3DVC

Supercategory

Resource

Original Submitter

Anonymous

Version Status

Curated

Submitted On

12:00am June 26, 2012

Originated From

SciCrunch

Changes from Previous Version

First Version

Version 1

Created 3 years ago by Anonymous

Brainpeps: the blood-brain barrier peptide database.

  • Van Dorpe S
  • Brain Struct Funct
  • 2012 25

Peptides are able to cross the blood-brain barrier (BBB) through various mechanisms, opening new diagnostic and therapeutic avenues. However, their BBB transport data are scattered in the literature over different disciplines, using different methodologies reporting different influx or efflux aspects. Therefore, a comprehensive BBB peptide database (Brainpeps) was constructed to collect the BBB data available in the literature. Brainpeps currently contains BBB transport information with positive as well as negative results. The database is a useful tool to prioritize peptide choices for evaluating different BBB responses or studying quantitative structure-property (BBB behaviour) relationships of peptides. Because a multitude of methods have been used to assess the BBB behaviour of compounds, we classified these methods and their responses. Moreover, the relationships between the different BBB transport methods have been clarified and visualized.